Nav: Home

Looking to the future of organs-on-chip

June 06, 2017

A new special issue from Future Science OA examines novel organ-on-a-chip research and provides expert insight into the future of the field.

It is well-accepted that 2D cell cultures are not fully reflective of the in vivo environment. This leads to issues translating research to the clinic. In a bid to overcome this, advances in lab-on-a-chip technology have begun to allow the development of platforms where cells, spheroids and tissue cultures can be cultured, thus allowing more accurate analysis and translation.

Organ-on-a-chip (OOAC) technology holds great potential in helping screen drugs in a more cost-effective manner, reducing failures, costs and pipeline time. Further potential advantages of OOAC technology going forward include a reduced need for animal models, and improved ability to personalize patient treatment.

The new special issue from Future Science OA sees Guest Editor John Greenman (University of Hull, UK) and an international group of experts discuss work at the forefront of OOAC research. "There are so many areas of biomedicine that require accurate and reproducible models of the human system," commented Greenman. "The ability to keep organs in a functional state on chip, either alone or combined, will offer an ethically acceptable platform with real power to transform our understanding."

The issue contains novel perspectives from across the multidisciplinary field, including both academics and those working in industry. In addition to in-depth discussion of various applications of OOAC including work on heart-on-a-chip, stem cells, spheroids and tissue biopsies, the issue presents new research into maintaining tumor biopsies and a survey evaluating end-user attitudes toward microfluidics-based cell culture.

"It has been a pleasure working with such a broad range of experts in the field to develop this timely special issue on OOAC," commented Francesca Lake, Managing Editor of Future Science OA. "We hope the issue will stimulate further research into this up-and-coming field, and are excited to see what the future holds."
-end-
The full issue is open access, and available at: http://www.future-science.com/toc/fso/3/2

The issue foreword is available from: http://www.future-science.com/doi/full/10.4155/fsoa-2017-0040. An introductory video is available at: https://www.youtube.com/watch?v=yyAKF7bOQeA.

Future Science Group

Related Stem Cells Articles:

Computer simulations visualize how DNA is recognized to convert cells into stem cells
Researchers of the Hubrecht Institute (KNAW - The Netherlands) and the Max Planck Institute in Münster (Germany) have revealed how an essential protein helps to activate genomic DNA during the conversion of regular adult human cells into stem cells.
First events in stem cells becoming specialized cells needed for organ development
Cell biologists at the University of Toronto shed light on the very first step stem cells go through to turn into the specialized cells that make up organs.
Surprising research result: All immature cells can develop into stem cells
New sensational study conducted at the University of Copenhagen disproves traditional knowledge of stem cell development.
The development of brain stem cells into new nerve cells and why this can lead to cancer
Stem cells are true Jacks-of-all-trades of our bodies, as they can turn into the many different cell types of all organs.
Healthy blood stem cells have as many DNA mutations as leukemic cells
Researchers from the Princess Máxima Center for Pediatric Oncology have shown that the number of mutations in healthy and leukemic blood stem cells does not differ.
New method grows brain cells from stem cells quickly and efficiently
Researchers at Lund University in Sweden have developed a faster method to generate functional brain cells, called astrocytes, from embryonic stem cells.
NUS researchers confine mature cells to turn them into stem cells
Recent research led by Professor G.V. Shivashankar of the Mechanobiology Institute at the National University of Singapore and the FIRC Institute of Molecular Oncology in Italy, has revealed that mature cells can be reprogrammed into re-deployable stem cells without direct genetic modification -- by confining them to a defined geometric space for an extended period of time.
Researchers develop a new method for turning skin cells into pluripotent stem cells
Researchers at the University of Helsinki, Finland, and Karolinska Institutet, Sweden, have for the first time succeeded in converting human skin cells into pluripotent stem cells by activating the cell's own genes.
In mice, stem cells seem to work in fighting obesity! What about stem cells in humans?
This release aims to summarize the available literature in regard to the effect of Mesenchymal Stem Cells transplantation on obesity and related comorbidities from the animal model.
TSRI researchers identify gene responsible for mesenchymal stem cells' stem-ness'
Researchers at The Scripps Research Institute recently published a study in the journal Cell Death and Differentiation identifying factors crucial to mesenchymal stem cell differentiation, providing insight into how these cells should be studied for clinical purposes.
More Stem Cells News and Stem Cells Current Events

Trending Science News

Current Coronavirus (COVID-19) News

Top Science Podcasts

We have hand picked the top science podcasts of 2020.
Now Playing: TED Radio Hour

Listen Again: Reinvention
Change is hard, but it's also an opportunity to discover and reimagine what you thought you knew. From our economy, to music, to even ourselves–this hour TED speakers explore the power of reinvention. Guests include OK Go lead singer Damian Kulash Jr., former college gymnastics coach Valorie Kondos Field, Stockton Mayor Michael Tubbs, and entrepreneur Nick Hanauer.
Now Playing: Science for the People

#562 Superbug to Bedside
By now we're all good and scared about antibiotic resistance, one of the many things coming to get us all. But there's good news, sort of. News antibiotics are coming out! How do they get tested? What does that kind of a trial look like and how does it happen? Host Bethany Brookeshire talks with Matt McCarthy, author of "Superbugs: The Race to Stop an Epidemic", about the ins and outs of testing a new antibiotic in the hospital.
Now Playing: Radiolab

Dispatch 6: Strange Times
Covid has disrupted the most basic routines of our days and nights. But in the middle of a conversation about how to fight the virus, we find a place impervious to the stalled plans and frenetic demands of the outside world. It's a very different kind of front line, where urgent work means moving slow, and time is marked out in tiny pre-planned steps. Then, on a walk through the woods, we consider how the tempo of our lives affects our minds and discover how the beats of biology shape our bodies. This episode was produced with help from Molly Webster and Tracie Hunte. Support Radiolab today at Radiolab.org/donate.