Is white or whole wheat bread 'healthier?' Depends on the person

June 06, 2017

Despite many studies looking at which bread is the healthiest, it is still not clear what effect bread and differences among bread types have on clinically relevant parameters and on the microbiome. In the journal Cell Metabolism on June 6, Weizmann Institute researchers report the results of a comprehensive, randomized trial in 20 healthy subjects comparing differences in how processed white bread and artisanal whole wheat sourdough affect the body.

Surprisingly, the investigators found the bread itself didn't greatly affect the participants and that different people reacted differently to the bread. The research team then devised an algorithm to help predict how individuals may respond to the bread in their diets.

All of the participants in the study normally consumed about 10% of their calories from bread. Half were assigned to consume an increased amount of processed, packaged white bread for a week--around 25% of their calories--and half to consume an increased amount of whole wheat sourdough, which was baked especially for the study and delivered fresh to the participants. After a 2-week period without bread, the diets for the two groups were reversed.

Before the study and throughout the time it was ongoing, many health effects were monitored. These included wakeup glucose levels; levels of the essential minerals calcium, iron, and magnesium; fat and cholesterol levels; kidney and liver enzymes; and several markers for inflammation and tissue damage. The investigators also measured the makeup of the participants' microbiomes before, during, and after the study.

"The initial finding, and this was very much contrary to our expectation, was that there were no clinically significant differences between the effects of these two types of bread on any of the parameters that we measured," says Eran Segal (@segal_eran), a computational biologist at the Weizmann Institute of Science and one of the study's senior authors. "We looked at a number of markers, and there was no measurable difference in the effect that this type of dietary intervention had."

Based on some of their earlier work, however, which found that different people have different glycemic responses to the same diet, the investigators suspected that something more complicated may be going on: perhaps the glycemic response of some of the people in the study was better to one type of bread, and some better to the other type. A closer look indicated that this was indeed the case. About half the people had a better response to the processed, white flour bread, and the other half had a better response to the whole wheat sourdough. The lack of differences were only seen when all findings were averaged together.

"The findings for this study are not only fascinating but potentially very important, because they point toward a new paradigm: different people react differently, even to the same foods," says Eran Elinav (@EranElinav), a researcher in the Department of Immunology at the Weizmann Institute and another of the study's senior authors. "To date, the nutritional values assigned to food have been based on minimal science, and one-size-fits-all diets have failed miserably."

He adds: "These findings could lead to a more rational approach for telling people which foods are a better fit for them, based on their microbiomes."

Avraham Levy, a professor in the Department of Plant and Environmental Sciences and another coauthor, adds a caveat to the study: "These experiments looked at everyone eating the same amounts of carbohydrates from both bread types, which means that they ate more whole wheat bread because it contains less available carbohydrates. Moreover, we know that because of its high fiber content, people generally eat less whole wheat bread. We didn't take into consideration how much you would eat based on how full you felt. So the story must go on."
This research was supported by the Ministry of Science, Technology, and Space, Israel; Yael and Rami Ungar, Israel; Leona M. and Harry B. Helmsley Charitable Trust; the Gurwin Family Fund for Scientific Research; Crown Endowment Fund for Immunological Research; estate of Jack Gitlitz; estate of Lydia Hershkovich; the Benoziyo Endowment Fund for the Advancement of Science; Adelis Foundation; John L. and Vera Schwartz, Pacific Palisades; Alan Markovitz, Canada; Cynthia Adelson, Canada; estate of Samuel and Alwyn J. Weber; Mr. and Mrs. Donald L. Schwarz, Sherman Oaks; and the Alon Foundation scholar award. Funding also came from the Rina Gudinski Career Development Chair; the Canadian Institute For Advanced Research (CIFAR); the Crown Human Genome Center; the Else Kroener Fresenius Foundation; Donald L. Schwarz, Sherman Oaks, CA; Jack N. Halpern, New York, NY; Leesa Steinberg, Canada; and grants from the European Research Council and the Israel Science Foundation.

Cell Metabolism, Korem et al: "Bread affects clinical parameters and induces gut microbiome-associated personal glycemic responses."

Cell Metabolism (@Cell_Metabolism), published by Cell Press, is a monthly journal that publishes reports of novel results in metabolic biology, from molecular and cellular biology to translational studies. The journal aims to highlight work addressing the molecular mechanisms underlying physiology and homeostasis in health and disease. Visit: To receive Cell Press media alerts, contact

Cell Press

Related Based Articles from Brightsurf:

Graphene-based memory resistors show promise for brain-based computing
As progress in traditional computing slows, new forms of computing are coming to the forefront.

Towards next-generation molecule-based magnets
Magnets are to be found everywhere in our daily lives, whether in satellites, telephones or on fridge doors.

Smart fluorescent molecular switches based on boron-based compounds
Scientists have developed extremely stable molecular switches of high luminosity that self-assemble into 1D nanostructures and form gel-like materials.

Structural colors from cellulose-based polymers
A surface displays structural colors when light is reflected by tiny, regular structural elements in a transparent material.

Novel approach improves graphene-based supercapacitors
An efficient in situ pathway to generate and attach oxygen functional groups to graphitic electrodes for supercapacitors by inducing hydrolysis of water molecules within the gel electrolyte.

Biomedical instrument based on microvesicles
Researchers have proved that a microvesicle-based instrument can be effective in reducing inflammation and immune response.

GLP-1-based treatment of diabetes does not cause pancreatitis
The commonly used treatment for type 2 diabetes and obesity, GLP-1, does not cause pancreatitis.

Construction of sintering resistant Pt based catalyst based on 'composite energy well' model
A recent study reported a new approach that can effectively inhibit the migration and agglomeration of supported nanoparticles by fabrication of a model catalyst Pt/CeO2/NiAl2O4/Al2O3@SiO2.

Printing complex cellulose-based objects
Researchers from ETH Zurich and the Swiss Federal Laboratories for Materials Science and Technology (Empa) have set a new world record: they 3D printed complex objects with higher cellulose content than that of any other additively manufactured cellulose-based parts.

The first Cr-based nitrides superconductor Pr3Cr10-xN11
New novel Cr-based nitride superconductor is discovered in cubic nitrides Pr3Cr10-xN11 at 5.25 K.

Read More: Based News and Based Current Events is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to