Nav: Home

The FASEB Journal: New psoriatric arthritis mouse model developed

June 06, 2019

Psoriatic arthritis (PsA) is a chronic inflammatory disease that can reduce mobility and agility in patients. PsA is known to increase the risk of type II diabetes. A recent study published in The FASEB Journal tested a novel mouse model that may one day lead to therapeutic approaches or reagents for human skin pathology, as well as joint erosion and disc degeneration, that would improve quality of life for patients with PsA.

To conduct the study, researchers used two groups of non-obese diabetic (NOD) mice. One group was infected with an adenoviral vector engineered to express a single-chain IL-23 (pro-inflammatory cytokine), while the other was infected with a control virus. The group infected with the IL-23 virus developed PsA following a single intravenous injection. The systemic delivery of the virus allowed for the development of a broad array of symptoms often seen in human PsA patients, including skin, disc, and joint disease. The development of these symptoms makes this the only mouse model of PsA.

"This novel mouse model represents an excellent model of human PsA that encompasses most symptoms of human disease," said Paul Robbins, professor of biochemistry, molecular biology, and biophysics at the University of Minnesota. "The model can be used to test and optimize PsA therapies, thus improving quality of life for PsA patients."

In another surprising finding, the research team observed that IL-23 did not accelerate diabetes, but actually delayed the onset of hyperglycemia, or high blood sugar.

"This disease has needed a robust animal model system for some time and this study constitutes such an advance," said Thoru Pederson, PhD, Editor-in-Chief of The FASEB Journal.
-end-
The FASEB Journal is published by the Federation of the American Societies for Experimental Biology (FASEB). The world's most cited biology journal according to the Institute for Scientific Information, it has been recognized by the Special Libraries Association as one of the top 100 most influential biomedical journals of the past century.

FASEB is composed of 29 societies with more than 130,000 members, making it the largest coalition of biomedical research associations in the United States. FASEB's mission is to advance health and well-being by promoting research and education in biological and biomedical sciences through collaborative advocacy and service to member societies and their members.

Federation of American Societies for Experimental Biology

Related Psoriatic Arthritis Articles:

Tildrakizumab shows promising efficacy and safety in psoriatic arthritis
The results of a phase 2B study presented today at the Annual European Congress of Rheumatology (EULAR 2019) demonstrate superior efficacy and comparable safety of tildrakizumab versus placebo in patients with psoriatic arthritis.
No link between cancer and tumor necrosis factor inhibitor (TNFi) use in psoriatic arthritis
The results of a study presented today at the Annual European Congress of Rheumatology (EULAR 2019) suggest that overall cancer risk is not linked to tumor necrosis factor inhibitor (TNFi) use in psoriatic arthritis.
Being overweight linked to significantly higher disease severity in psoriatic arthritis
The results of a study presented today at the Annual European Congress of Rheumatology (EULAR 2019) demonstrate significant correlation between body mass index (BMI) and disease severity in psoriatic arthritis.
Imaging tests help reveal heart risks in patients with psoriatic disease
Patients with psoriasis and psoriatic arthritis -- collectively termed psoriatic disease -- face increased heart risks.
The ACR and the Arthritis Foundation present new guidelines offering therapeutic approaches and treatment options for juvenile idiopathic arthritis
Today, the American College of Rheumatology (ACR), in partnership with the Arthritis Foundation (AF), released two guidelines on juvenile idiopathic arthritis (JIA).
More Psoriatic Arthritis News and Psoriatic Arthritis Current Events

Best Science Podcasts 2019

We have hand picked the best science podcasts for 2019. Sit back and enjoy new science podcasts updated daily from your favorite science news services and scientists.
Now Playing: TED Radio Hour

Rethinking Anger
Anger is universal and complex: it can be quiet, festering, justified, vengeful, and destructive. This hour, TED speakers explore the many sides of anger, why we need it, and who's allowed to feel it. Guests include psychologists Ryan Martin and Russell Kolts, writer Soraya Chemaly, former talk radio host Lisa Fritsch, and business professor Dan Moshavi.
Now Playing: Science for the People

#537 Science Journalism, Hold the Hype
Everyone's seen a piece of science getting over-exaggerated in the media. Most people would be quick to blame journalists and big media for getting in wrong. In many cases, you'd be right. But there's other sources of hype in science journalism. and one of them can be found in the humble, and little-known press release. We're talking with Chris Chambers about doing science about science journalism, and where the hype creeps in. Related links: The association between exaggeration in health related science news and academic press releases: retrospective observational study Claims of causality in health news: a randomised trial This...