Addressing antibiotic resistance: Breath analysis aims to reduce unnecessary prescriptions

June 07, 2016

The overuse of antibiotics gives harmful bacteria the opportunity to evolve into drug resistant strains that threaten health care. To help tackle the problem, scientists in China have begun a pilot study examining biomarkers exhaled by patients. The team's goal is to develop an efficient (fast, accurate, painless and affordable) test that will assist doctors in prescribing antibiotics only when the treatment is absolutely necessary.

Reporting their first results in Journal of Breath Research, the researchers based at Zhejiang University have used benchtop analytical methods as a stepping stone towards developing future diagnostic tools.

The group is focusing its initial work on ventilator-associated pneumonia patients in the intensive care unit. Here it is critically important to differentiate between life-threatening bacterial infection and common colonization to avoid prescribing antibiotics unnecessarily.

"To confirm whether patients have a bacterial infection of the respiratory tract, doctors currently have to take a number of different samples (blood and sputum), and even chest x-rays in the case of pneumonia," explained Kejing Ying, who is coordinating the work and is based at the Zhejiang University School of Medicine.

Breathe in, breathe out

Analysing samples from 60 volunteers, the scientists have found a potentially useful link between the presence of exhaled acinetobacter baumannii derived volatile organic compounds (VOCs) and patients diagnosed with bacterial pneumonia.

"The challenge we face is that many VOCs are not unique to one pathogen," added Ying who is working with colleagues at Zhejiang University's Department of Biomedical Engineering.

Ultimately, the team hopes that its research will lead to an approved non-invasive test to provide early warning of bacterial infection in the lower respiratory tract.
-end-


IOP Publishing

Related Antibiotics Articles from Brightsurf:

Insights in the search for new antibiotics
A collaborative research team from the University of Oklahoma, the Memorial Sloan Kettering Cancer Center and Merck & Co. published an opinion article in the journal, Nature Chemical Biology, that addresses the gap in the discovery of new antibiotics.

New tricks for old antibiotics
The study published in the journal Immunity reveals that tetracyclines (broad spectre antibiotics), by partially inhibiting cell mitochondria activity, induce a compensatory response on the organism that decreases tissue damage caused during infection.

Benefits, risks seen with antibiotics-first for appendicitis
Antibiotics are a good choice for some patients with appendicitis but not all, according to study results published today in the New England Journal of Medicine.

How antibiotics interact
Understanding bottleneck effects in the translation of bacterial proteins can lead to a more effective combination of antibiotics / study in 'Nature Communications'

Are antivitamins the new antibiotics?
Antibiotics are among the most important discoveries of modern medicine and have saved millions of lives since the discovery of penicillin almost 100 years ago.

Hygiene reduces the need for antibiotics by up to 30%
A new paper published in the American Journal of Infection Control (AJIC), finds improved everyday hygiene practices, such as hand-washing, reduces the risk of common infections by up to 50%, reducing the need for antibiotics, by up to 30%.

Antibiotics: City dwellers and children take the most
City dwellers take more antibiotics than people in rural areas; children and the elderly use them more often than middle-aged people; the use of antibiotics decreases as education increases, but only in rich countries: These are three of the more striking trends identified by researchers of the NRW Forschungskolleg ''One Health and Urban Transformation'' at the University of Bonn.

Metals could be the link to new antibiotics
Compounds containing metals could hold the key to the next generation of antibiotics to combat the growing threat of global antibiotic resistance.

Antibiotics from the sea
The team led by Prof. Christian Jogler of Friedrich Schiller University, Jena, has succeeded in cultivating several dozen marine bacteria in the laboratory -- bacteria that had previously been paid little attention.

Antibiotics not necessary for most toothaches, according to new ADA guideline
The American Dental Association (ADA) announced today a new guideline indicating that in most cases, antibiotics are not recommended for toothaches.

Read More: Antibiotics News and Antibiotics Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.