Nav: Home

Children from older mothers more likely to have heart risks

June 07, 2018

New research published in The Journal of Physiology demonstrates that adult offspring born to older mothers are more susceptible to heart risks in later life. These results could be crucial in developing preventative treatments for children born to older women.

Older motherhood is associated with an increased risk of complications during pregnancy with a greater likelihood of delivering a child that is premature or born small. As giving birth at an older age is becoming more common, it is important to understand the consequences for these children in adulthood.

The research, conducted by investigators at the University of Alberta, Canada, highlights the need for improved access to healthcare for children born to older mothers. It also suggests that intervention strategies should be tailored according to sex, as female offspring did not demonstrate the same susceptibility to heart problems or impaired blood vessels as male offspring.

To investigate the impact of the age a mother gives birth on the health of her offspring, older female rats, which were equivalent to a 35-year-old human, were mated with young males. At 4 months, their offspring's blood vessel and heart function were tested. In future studies, the researchers will look into whether or not the findings are true in human subjects.

The principal investigator on the project, Sandra T Davidge, said: 'This research is important because it improves our understanding of the impact of giving birth at an older age on the health of offspring in later life. We are further analysing the mechanisms that might be contributing to these adverse effects on the offspring of older mothers, in particular focusing on the role of placental function.'
-end-


The Physiological Society

Related Heart Function Articles:

Anabolic-androgenic steroid use associated with decreased heart function in weightlifters
Illicit performance-enhancing steroids can cause the heart to thicken and reduce its ability to function, according to research presented today at ESC Congress 2019 together with the World Congress of Cardiology.
Restoring this enzyme's function protects against heart disease in lupus and beyond
Patients with lupus are at increased risk of heart disease.
New practice corrects pump function in heart failure
Late-breaking results from the ElectroCRT trial presented today at EHRA 2019 a European Society of Cardiology (ESC) congress, pave the way for a new standard of care to improve the heart's pump function in selected patients with heart failure.
Ultrasound provides precise, minimally invasive way to measure heart function in children
Currently, a practical, precise, minimally invasive way to measure cardiac output or heart function in children undergoing surgery does not exist.
Micropeptide restores heart function in mice
Researchers have discovered a micropeptide molecule that can restore normal heart function in mice, according to a study in eLife.
A protein could be key to preserving heart function in Duchenne muscular dystrophy
The brain-derived neurotrophic factor protein, known to be vital for brain function, might hold the key for preserving heart function in children and young adults with Duchenne muscular dystrophy.
Being overweight may change young adults' heart structure, function
Being overweight may cause higher blood pressure and changes to the heart's structure, even in young adults.
Stem cells restore function in primate heart-failure study
Human stem cells have been successfully used to restore heart function in monkeys with heart failure.
Scientists discover why heart function is reduced at high altitude
For over a century, we have known that high altitude reduces the amount of blood the heart pumps around the body with each beat.
Implantable machines measure heart function
Scientists have devised a method to obtain critical information about cardiac function -- using machines that help failing hearts circulate blood.
More Heart Function News and Heart Function Current Events

Best Science Podcasts 2019

We have hand picked the best science podcasts for 2019. Sit back and enjoy new science podcasts updated daily from your favorite science news services and scientists.
Now Playing: TED Radio Hour

Rethinking Anger
Anger is universal and complex: it can be quiet, festering, justified, vengeful, and destructive. This hour, TED speakers explore the many sides of anger, why we need it, and who's allowed to feel it. Guests include psychologists Ryan Martin and Russell Kolts, writer Soraya Chemaly, former talk radio host Lisa Fritsch, and business professor Dan Moshavi.
Now Playing: Science for the People

#538 Nobels and Astrophysics
This week we start with this year's physics Nobel Prize awarded to Jim Peebles, Michel Mayor, and Didier Queloz and finish with a discussion of the Nobel Prizes as a way to award and highlight important science. Are they still relevant? When science breakthroughs are built on the backs of hundreds -- and sometimes thousands -- of people's hard work, how do you pick just three to highlight? Join host Rachelle Saunders and astrophysicist, author, and science communicator Ethan Siegel for their chat about astrophysics and Nobel Prizes.