Nav: Home

Proof of sandwiched graphene-membrane superstructure opens up a membrane-specific drug delivery mode

June 07, 2019

Researchers from the Institute of Process Engineering (IPE) of the Chinese Academy of Sciences and Tsinghua University (THU) proved a sandwiched superstructure for graphene oxide (GO) that transport inside cell membranes for the first time.

The discovery, published in Science Advances, opens up a membrane-specific drug delivery mode, which could significantly improve cytotoxicity effects over traditional drug carriers.

The transport of nanoparticles at bio-nano interfaces is essential for cellular responses and biomedical applications. How two-dimensional nanomaterials interact or diffuse inside the cell membrane is unknown, thus hindering their applications in the biomedical area.

"The sandwiched graphene membrane is a long-simulated superstructure but an unproved issue in vitro. We are excited to provide substantial experimental evidence and open an avenue for novel membrane-specific drug delivery," said WEI Wei, a professor from the State Key Laboratory of Biochemical Engineering of IPE.

The formation process of sandwiched GO was visualized in a fully hydrated/native state, and the significant influence on cell roughness, cell fluidity and membrane rigidity was also revealed.

Furthermore, the sandwiched GO induced greater drug entry and quicker diffusion time inside the membrane lipid layer, thus outperforming a typical liposome carrier in anti-cancer efficacy. This feature is also extremely beneficial when delivering vaccine adjuvants (e.g., membrane receptor ligands) for enhanced immune effect, according to WEI.

All the cell interactions, diffusion dynamics and the enhanced efficiency of membrane-specific drug delivery of sandwiched GO were simulated by Prof. YAN Litang from THU.

"It is a very nice study of graphene-membrane superstructures. It discloses different transport regimes, the presence of pores and a number of other potentially interesting features related to these systems," said peer reviewers from Science Advances. "Moreover, they demonstrate the applicability of GOs for drug delivery. Overall, the paper is very timely and tells a good story."

The GO-based sandwiched superstructure offers immense design capabilities that may enable a considerable number of applications for these emerging nanomaterials in the cutting-edge fields of biological and medical science.
-end-


Chinese Academy of Sciences Headquarters

Related Graphene Articles:

New 'brick' for nanotechnology: Graphene Nanomesh
Researchers at Japan advanced institute of science and technology (JAIST) successfully fabricated suspended graphene nanomesh (GNM) by using the focused helium ion beam technology.
Flatter graphene, faster electrons
Scientists from the Swiss Nanoscience Institute and the Department of Physics at the University of Basel developed a technique to flatten corrugations in graphene layers.
Graphene Flagship publishes handbook of graphene manufacturing
The EU-funded research project Graphene Flagship has published a comprehensive guide explaining how to produce and process graphene and related materials (GRMs).
How to induce magnetism in graphene
Graphene, a two-dimensional structure made of carbon, is a material with excellent mechani-cal, electronic and optical properties.
Graphene: The more you bend it, the softer it gets
New research by engineers at the University of Illinois combines atomic-scale experimentation with computer modeling to determine how much energy it takes to bend multilayer graphene -- a question that has eluded scientists since graphene was first isolated.
How do you know it's perfect graphene?
Scientists at the US Department of Energy's Ames Laboratory have discovered an indicator that reliably demonstrates a sample's high quality, and it was one that was hiding in plain sight for decades.
Graphene is 3D as well as 2D
Graphene is actually a 3D material as well as a 2D material, according to a new study from Queen Mary University of London.
How to purify water with graphene
Scientists from the National University of Science and Technology 'MISIS' together with their colleagues from Derzhavin Tambov State University and Saratov Chernyshevsky State University have figured out that graphene is capable of purifying water, making it drinkable, without further chlorination.
Decoupled graphene thanks to potassium bromide
The use of potassium bromide in the production of graphene on a copper surface can lead to better results.
1 + 1 does not equal 2 for graphene-like 2D materials
Physicists from the University of Sheffield have discovered that when two atomically thin graphene-like materials are placed on top of each other their properties change, and a material with novel hybrid properties emerges, paving the way for design of new materials and nano-devices.
More Graphene News and Graphene Current Events

Trending Science News

Current Coronavirus (COVID-19) News

Top Science Podcasts

We have hand picked the top science podcasts of 2020.
Now Playing: TED Radio Hour

Listen Again: Reinvention
Change is hard, but it's also an opportunity to discover and reimagine what you thought you knew. From our economy, to music, to even ourselves–this hour TED speakers explore the power of reinvention. Guests include OK Go lead singer Damian Kulash Jr., former college gymnastics coach Valorie Kondos Field, Stockton Mayor Michael Tubbs, and entrepreneur Nick Hanauer.
Now Playing: Science for the People

#562 Superbug to Bedside
By now we're all good and scared about antibiotic resistance, one of the many things coming to get us all. But there's good news, sort of. News antibiotics are coming out! How do they get tested? What does that kind of a trial look like and how does it happen? Host Bethany Brookeshire talks with Matt McCarthy, author of "Superbugs: The Race to Stop an Epidemic", about the ins and outs of testing a new antibiotic in the hospital.
Now Playing: Radiolab

Dispatch 6: Strange Times
Covid has disrupted the most basic routines of our days and nights. But in the middle of a conversation about how to fight the virus, we find a place impervious to the stalled plans and frenetic demands of the outside world. It's a very different kind of front line, where urgent work means moving slow, and time is marked out in tiny pre-planned steps. Then, on a walk through the woods, we consider how the tempo of our lives affects our minds and discover how the beats of biology shape our bodies. This episode was produced with help from Molly Webster and Tracie Hunte. Support Radiolab today at Radiolab.org/donate.