Cost-effectiveness of HIV/AIDS interventions in South Africa

June 08, 2017

An international African collaboration has turned to statistical analysis to determine the cost effectiveness of major HIV/AIDS interventions in South Africa with a view to advising policy makers on the optimal approach to managing the disease. Details are reported this month in the International Journal of Economics and Business Research.

Josue Mbonigaba of the University of KwaZulu-Natal, in Durban, South Africa, working with Saidou Baba Oumar of The University of Bamenda, in Bambili, and the University of Buea, both in Cameroon point out that a shortage of resources in South Africa to address the high burden of HIV/AIDS requires that different strategies must be adopted in rural and urban regions. The team explains that despite major advances in coping with AIDS elsewhere in the world, South Africa continues to suffer the burden of this devastating disease with many millions living with HIV/AIDS (ca 5.51 million in 2015). The high prevalence is a consequence of an exponential increase in infections through the late 1990s and early 2000s, which the team attributes to the slow response of the government to the crisis.

The team has used Markov state transition models, the spectrum policy modeling system and sensitivity analysis to estimate the cost-effectiveness (CE) of different interventions. The interventions discussed are: prevention of mother-to-child transmission of the virus, use of highly active antiretroviral drugs in adults and in children.

They have found that running HIV/AIDS interventions and expecting to achieve the same cost effectiveness across both rural and urban areas is erroneous. They point out that, factors affecting cost effectiveness, such as earlier or increased access to interventions have more significant influence in rural areas than they do in urban areas. "This result is crucial for South African policymakers, who have been seeking to address the dichotomy between rural and urban areas," the team reports. "Factors linking earlier access and usage of interventions include stigmatization and other cultural factors." As such, these issues must be addressed if interventions are to have the deepest impact and bring South Africa out of this medical crisis sooner rather than later.
Mbonigaba, J. and Oumar, S.B. (2017) 'The cost-effectiveness of major HIV/AIDS interventions in rural and urban areas in South Africa', Int. J. Economics and Business Research, Vol. 13, No. 4, pp.413-434.

Inderscience Publishers

Related Disease Articles from Brightsurf:

CLCN6 identified as disease gene for a severe form of lysosomal neurodegenerative disease
A mutation in the CLCN6 gene is associated with a novel, particularly severe neurodegenerative disorder.

Cellular pathway of genetic heart disease similar to neurodegenerative disease
Research on a genetic heart disease has uncovered a new and unexpected mechanism for heart failure.

Mechanism linking gum disease to heart disease, other inflammatory conditions discovered
The link between periodontal (gum) disease and other inflammatory conditions such as heart disease and diabetes has long been established, but the mechanism behind that association has, until now, remained a mystery.

Potential link for Alzheimer's disease and common brain disease that mimics its symptoms
A new study by investigators from Brigham and Women's Hospital uncovered a group of closely related genes that may capture molecular links between Alzheimer's disease and Limbic-predominant Age-related TDP-43 Encephalopathy, or LATE, a recently recognized common brain disorder that can mimic Alzheimer's symptoms.

Antioxidant agent may prevent chronic kidney disease and Parkinson's disease
Researchers from Osaka University developed a novel dietary silicon-based antioxidant agent with renoprotective and neuroprotective effects.

Tools used to study human disease reveal coral disease risk factors
In a study published in Scientific Reports, a team of international researchers led by University of Hawai'i (UH) at Mānoa postdoctoral fellow Jamie Caldwell used a statistical technique typically employed in human epidemiology to determine the ecological risk factors affecting the prevalence of two coral diseases--growth anomalies, abnormalities like coral tumors, and white syndromes, infectious diseases similar to flesh eating bacteria.

Disease-aggravating mutation found in a mouse model of neonatal mitochondrial disease
The new mitochondrial DNA (mtDNA) variant drastically speeds up the disease progression in a mouse model of GRACILE syndrome.

Human longevity largest study of its kind shows early detection of disease & disease risks
Human Longevity, Inc. (HLI) announced the publication of a ground-breaking study in the journal Proceedings of the National Academy of Sciences (PNAS).

30-year study identifies need of disease-modifying therapies for maple syrup urine disease
A new study analyzes 30 years of patient data and details the clinical course of 184 individuals with genetically diverse forms of Maple Syrup Urine Disease (MSUD), which is among the most volatile and dangerous inherited metabolic disorders.

Long-dormant disease becomes most dominant foliar disease in New York onion crops
Until recently, Stemphylium leaf blight has been considered a minor foliar disease as it has not done much damage in New York since the early 1990s.

Read More: Disease News and Disease Current Events is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to