Nav: Home

Fat tissue may impede radiotherapy for breast cancer patients

June 08, 2017

According to research published online in The FASEB Journal, repeated irradiation of breast fat (also known as adipose tissue) produces an inflammatory response that ultimately reduces the efficiency of radiotherapy in breast cancer patients. This research was based on a recent discovery that there is an inflammatory interaction between breast tumors and adipose tissue.

"Patients often undergo 25 daily doses of radiotherapy to the whole breast after surgical removal of the tumor to ensure that any remaining breast cancer cells are destroyed," said David N. Brindley, Ph.D., D.Sc., professor at the Heritage Medical Research Centre within the Department of Biochemistry at Canada's University of Alberta. "During this treatment, the adipose tissue releases autotaxin, an enzyme that initiates a wound healing response. This response ends up protecting the remaining cancer cells and allowing tumors to establish themselves and avoid destruction."

To test this idea, Brindley and colleagues exposed rat and human adipose tissue to radiation doses expected during radiotherapy. The radiation produced an increase in autotaxin and an inflammatory wound healing response. The researchers identified several agents that could be used to block inflammation and decrease the wound healing response, which they expect would improve the effectiveness of the radiotherapy.

"This is a potentially major discovery in relation to the efficacy of breast cancer radiation therapy" said Thoru Pederson, Ph.D., Editor-in-Chief of The FASEB Journal.
-end-
Submit to The FASEB Journal by visiting http://fasebj.msubmit.net, and receive monthly highlights by signing up at http://www.faseb.org/fjupdate.aspx. The FASEB Journal is published by the Federation of the American Societies for Experimental Biology (FASEB). It is the world's most cited biology journal according to the Institute for Scientific Information and has been recognized by the Special Libraries Association as one of the top 100 most influential biomedical journals of the past century.

FASEB is composed of 30 societies with more than 125,000 members, making it the largest coalition of biomedical research associations in the United States. Our mission is to advance health and welfare by promoting progress and education in biological and biomedical sciences through service to our member societies and collaborative advocacy.

Details: Guanmin Meng, Xiaoyun Tang, Zelei Yang, Matthew G. K. Benesch, Alison Marshall, David Murray, Denise G. Hemmings, Frank Wuest, Todd P. W. McMullen, and David N. Brindley. Implications for breast cancer treatment from increased autotaxin production in adipose tissue after radiotherapy. FASEB J. doi:10.1096/fj.201700159R ; http://www.fasebj.org/content/early/2017/05/24/fj.201700159R.abstract

Federation of American Societies for Experimental Biology

Related Radiotherapy Articles:

Men can be spared radiotherapy after surgery
Men with prostate cancer can be spared radiotherapy after surgery, according to late breaking results from a study led by The Royal Marsden NHS Foundation Trust.
Men with prostate cancer can be spared radiotherapy after surgery
Men with prostate cancer can be spared radiotherapy after surgery, according to late breaking results of the RADICALS-RT trial presented at the ESMO Congress 2019 in Barcelona, Spain.
Radiotherapy targets tumours precisely -- with less damage to healthy cells
A new way of concentrating radiotherapy dose in tumours, while minimising damage to healthy cells, has been proposed in research led by scientists at the University of Strathclyde.
Hurricane disasters associated with poorer outcomes for radiotherapy patients
Lung cancer patients who had a hurricane disaster declared during radiotherapy had worse overall survival than those who completed treatment in normal circumstances.
Women in developing countries need radiotherapy and vaccines for cervical cancer
Millions of women in low- and middle-income countries will need life-saving radiotherapy to treat their cervical cancer, despite the growth of essential human papilloma virus (HPV) vaccination prevention programs.
More Radiotherapy News and Radiotherapy Current Events

Best Science Podcasts 2019

We have hand picked the best science podcasts for 2019. Sit back and enjoy new science podcasts updated daily from your favorite science news services and scientists.
Now Playing: TED Radio Hour

Rethinking Anger
Anger is universal and complex: it can be quiet, festering, justified, vengeful, and destructive. This hour, TED speakers explore the many sides of anger, why we need it, and who's allowed to feel it. Guests include psychologists Ryan Martin and Russell Kolts, writer Soraya Chemaly, former talk radio host Lisa Fritsch, and business professor Dan Moshavi.
Now Playing: Science for the People

#537 Science Journalism, Hold the Hype
Everyone's seen a piece of science getting over-exaggerated in the media. Most people would be quick to blame journalists and big media for getting in wrong. In many cases, you'd be right. But there's other sources of hype in science journalism. and one of them can be found in the humble, and little-known press release. We're talking with Chris Chambers about doing science about science journalism, and where the hype creeps in. Related links: The association between exaggeration in health related science news and academic press releases: retrospective observational study Claims of causality in health news: a randomised trial This...