Nav: Home

Phenothiazine derivatives may find use in photodynamic therapy

June 09, 2020

A group on organic compounds under Professor Ivan Stoikov's guidance has been working on phenothiazine derivatives at Kazan Federal University since 2016.

Probably the most well-known derivative among the general public is methylene blue - a dye with antiseptic properties.

According to co-author Alena Khadieva, recent studies also show its high potential for use as photochemical and photodynamic agent that can be applied in the incision area during surgical operations and for localized therapy of cancerous tumors. The main problem of using compounds similar in structure to methylene blue is their aggregation in aqueous media.

This paper is devoted to the preparation of new phenothiazine derivatives containing phenyl groups instead of alkyl groups, which, according to published data, will provide greater photochemical activity. The presence of phenyl groups should also provide steric hindrances to the dimerization of phenothiazine derivatives. It also leads to high absorption in the near-infrared spectrum. Near-infrared radiation is characterized by high penetration of biological tissues without damaging them. Photoactive antimicrobial, antibacterial and anti-cancer agents based on organic oligoaromatic and polyaromatic compounds are currently attracting increased attention of researchers, since this direction opens up prospects for overcoming antibiotic resistance.

The next objective of the study was to ensure high stability of the dispersions of new phenothiazine derivatives. For this, a binary associate was obtained in which the phenothiazine derivative containing carboxyl groups acts as an acid, and the deprotonated phenothiazine derivative as a base. Due to the presence of complementary groups, stable dispersions were obtained. The stability of the dispersions was confirmed by dynamic light scattering, and the composition of the associate - by ultraviolet spectroscopy. The particle morphology was also studied by scanning electron microscopy, which made it possible to establish that the formation of the associate also changes the shape of the particles.

The synthesis of new phenothiazine derivatives containing, along with phenyl groups, fragments capable of forming intermolecular hydrogen bonds and capable of forming stable dispersions in water, will significantly expand the scope of their application in the composition of materials for photodynamic therapy.

In addition to working to obtain more stable dispersions, as well as water-soluble phenothiazine derivatives for use in medicine, the group also plans to move further to creating phenothiazine-cyclophane associates for use as colorimetric test samples to determine the content of toxic ions. Some of the results were published in Synthesis of Tris-pillar [5] arene and Its Association with Phenothiazine Dye: Colorimetric Recognition of Anions.

Both inquiries under Dr. Vladimir Gorbachuk's supervision were financially supported by the Russian Science Foundation (Project No. 18-73-00293).

Due to the structural similarity of arylamine derivatives of phenothiazine with emeraldine (a popular conductive organic polymer), research for obtaining electrochemically active stable dispersions based on the emeraldine-phenothiazine associate is also seen as promising.
-end-


Kazan Federal University

Related Science Articles:

75 science societies urge the education department to base Title IX sexual harassment regulations on evidence and science
The American Educational Research Association (AERA) and the American Association for the Advancement of Science (AAAS) today led 75 scientific societies in submitting comments on the US Department of Education's proposed changes to Title IX regulations.
Science/Science Careers' survey ranks top biotech, biopharma, and pharma employers
The Science and Science Careers' 2018 annual Top Employers Survey polled employees in the biotechnology, biopharmaceutical, pharmaceutical, and related industries to determine the 20 best employers in these industries as well as their driving characteristics.
Science in the palm of your hand: How citizen science transforms passive learners
Citizen science projects can engage even children who previously were not interested in science.
Applied science may yield more translational research publications than basic science
While translational research can happen at any stage of the research process, a recent investigation of behavioral and social science research awards granted by the NIH between 2008 and 2014 revealed that applied science yielded a higher volume of translational research publications than basic science, according to a study published May 9, 2018 in the open-access journal PLOS ONE by Xueying Han from the Science and Technology Policy Institute, USA, and colleagues.
Prominent academics, including Salk's Thomas Albright, call for more science in forensic science
Six scientists who recently served on the National Commission on Forensic Science are calling on the scientific community at large to advocate for increased research and financial support of forensic science as well as the introduction of empirical testing requirements to ensure the validity of outcomes.
World Science Forum 2017 Jordan issues Science for Peace Declaration
On behalf of the coordinating organizations responsible for delivering the World Science Forum Jordan, the concluding Science for Peace Declaration issued at the Dead Sea represents a global call for action to science and society to build a future that promises greater equality, security and opportunity for all, and in which science plays an increasingly prominent role as an enabler of fair and sustainable development.
PETA science group promotes animal-free science at society of toxicology conference
The PETA International Science Consortium Ltd. is presenting two posters on animal-free methods for testing inhalation toxicity at the 56th annual Society of Toxicology (SOT) meeting March 12 to 16, 2017, in Baltimore, Maryland.
Citizen Science in the Digital Age: Rhetoric, Science and Public Engagement
James Wynn's timely investigation highlights scientific studies grounded in publicly gathered data and probes the rhetoric these studies employ.
Science/Science Careers' survey ranks top biotech, pharma, and biopharma employers
The Science and Science Careers' 2016 annual Top Employers Survey polled employees in the biotechnology, biopharmaceutical, pharmaceutical, and related industries to determine the 20 best employers in these industries as well as their driving characteristics.
Three natural science professors win TJ Park Science Fellowship
Professor Jung-Min Kee (Department of Chemistry, UNIST), Professor Kyudong Choi (Department of Mathematical Sciences, UNIST), and Professor Kwanpyo Kim (Department of Physics, UNIST) are the recipients of the Cheong-Am (TJ Park) Science Fellowship of the year 2016.
More Science News and Science Current Events

Trending Science News

Current Coronavirus (COVID-19) News

Top Science Podcasts

We have hand picked the top science podcasts of 2020.
Now Playing: TED Radio Hour

Listen Again: The Power Of Spaces
How do spaces shape the human experience? In what ways do our rooms, homes, and buildings give us meaning and purpose? This hour, TED speakers explore the power of the spaces we make and inhabit. Guests include architect Michael Murphy, musician David Byrne, artist Es Devlin, and architect Siamak Hariri.
Now Playing: Science for the People

#576 Science Communication in Creative Places
When you think of science communication, you might think of TED talks or museum talks or video talks, or... people giving lectures. It's a lot of people talking. But there's more to sci comm than that. This week host Bethany Brookshire talks to three people who have looked at science communication in places you might not expect it. We'll speak with Mauna Dasari, a graduate student at Notre Dame, about making mammals into a March Madness match. We'll talk with Sarah Garner, director of the Pathologists Assistant Program at Tulane University School of Medicine, who takes pathology instruction out of...
Now Playing: Radiolab

What If?
There's plenty of speculation about what Donald Trump might do in the wake of the election. Would he dispute the results if he loses? Would he simply refuse to leave office, or even try to use the military to maintain control? Last summer, Rosa Brooks got together a team of experts and political operatives from both sides of the aisle to ask a slightly different question. Rather than arguing about whether he'd do those things, they dug into what exactly would happen if he did. Part war game part choose your own adventure, Rosa's Transition Integrity Project doesn't give us any predictions, and it isn't a referendum on Trump. Instead, it's a deeply illuminating stress test on our laws, our institutions, and on the commitment to democracy written into the constitution. This episode was reported by Bethel Habte, with help from Tracie Hunte, and produced by Bethel Habte. Jeremy Bloom provided original music. Support Radiolab by becoming a member today at Radiolab.org/donate.     You can read The Transition Integrity Project's report here.