Cutting-edge research unveiled at 2015 AAPS National Biotechnology Conference

June 10, 2015

SAN FRANCISCO - Innovative vaccine and tumor research will be unveiled at the American Association of Pharmaceutical Scientists' (AAPS) National Biotechnology Conference (NBC). The meeting takes place Monday, June 8- Wednesday, June 10 at the San Francisco Marriott Marquis.

This year's conference is organized into five meeting workstreams: Chemistry, Manufacturing, and Controls (CMC) including Formulation, Characterization, Stability and Biomanufacturing; Research and Discovery; Clinical Pharmacology, Pharmacokinetic/Pharmacodynamic (PK/PD), and Bioanalytics; Regulatory; and Biomarkers and Imaging. Submitted abstracts showcase the breadth and depth of the research being presented, as well as the global reach of AAPS. Research highlights include:

Capture of Circulating Tumor Cells with Dual Antibody-Coated Nanomaterial for Cancer Metastasis Prevention.

Nearly all cancers can form metastic tumors, according to the National Cancer Institute. Jingjing Xie, a student at Fuzhou University in Fujian, China, is working to design safe and effective antibody-coated nanomaterials for capturing and restraining the rare circulating tumor cells (CTCs) for cancer metastasis prevention.

The study, for the first time, elucidates that dual antibody-coated nanomaterial can exhibit a significantly enhanced specificity in capturing and down-regulating CTCs in the absence or presence of interfering blood cells in comparison with their single antibody-coated counterparts. Work is being presented June 8, 2015 at 10:00 a.m. PST.

Penfluridol Suppresses In Vivo Pancreatic Tumor Growth by Autophagy Mediated Apoptosis.

Pancreatic cancer is the most aggressive cancer characterized by metastasis progression and has developed resistance to current FDA therapies. There are estimated to be about 48,960 new cases of pancreatic cancer in 2015, and it is the fourth most common cause of death every year in the U.S.

Alok Ranjan, a graduate student at Texas Tech University Health Sciences Center School of Pharmacy and his team are conducting important research using the antipsychotic drug penfluridol to suppress pancreatic tumor growth by autophagy mediated apoptosis. Work is being presented on June 10, 2015 at 10:00 a.m. PST.

Protective Immunity against Malaria after Vaccination with Mannosylated Liposomes Encapsulating Whole Parasites.

According to the CDC, there were an estimated 198 million cases of malaria worldwide and 500,000 people in 2013. While malaria is one of the oldest diseases in the world, there are no vaccines currently available. Ashwin Kumar Giddam and his team at the University of Queensland in Australia are working to provide immunity against malaria by developing a liposome vaccine formulation, which increased the survival rate of mice challenged with infectious parasites. Work is being presented June 9, 2015 at 10:00 a.m. PST.
About AAPS: The American Association of Pharmaceutical Scientists is a professional, scientific society of approximately 10,000 members employed in academia, industry, government and other research institutes worldwide. Founded in 1986, AAPS provides a dynamic international forum for the exchange of knowledge among scientists to serve the public and enhance their contributions to health. AAPS offers timely scientific programs, on-going education, information resources, opportunities for networking, and professional development.

About the AAPS National Biotechnology Conference: The 2015 AAPS National Biotechnology Conference (NBC) will gather scientists from industry, government, and academia for three days of educational offerings specifically geared toward the biotechnology sector of the pharmaceutical sciences. Follow us on social media; official hashtag for the meeting is #2015NBC. Visit for more information.

Editor's Note: Registration is complimentary for members of the media. All abstracts presented are available upon request. To register for the meeting or set up an interview with an expert, please contact Stacey May on-site at (703) 459-7677.

American Association of Pharmaceutical Scientists

Related Malaria Articles from Brightsurf:

Clocking in with malaria parasites
Discovery of a malaria parasite's internal clock could lead to new treatment strategies.

Breakthrough in malaria research
An international scientific consortium led by the cell biologists Volker Heussler from the University of Bern and Oliver Billker from the UmeƄ University in Sweden has for the first time systematically investigated the genome of the malaria parasite Plasmodium throughout its life cycle in a large-scale experiment.

Scientists close in on malaria vaccine
Scientists have taken another big step forward towards developing a vaccine that's effective against the most severe forms of malaria.

New tool in fight against malaria
Modifying a class of molecules originally developed to treat the skin disease psoriasis could lead to a new malaria drug that is effective against malaria parasites resistant to currently available drugs.

Malaria expert warns of need for malaria drug to treat severe cases in US
The US each year sees more than 1,500 cases of malaria, and currently there is limited access to an intravenously administered (IV) drug needed for the more serious cases.

Monkey malaria breakthrough offers cure for relapsing malaria
A breakthrough in monkey malaria research by two University of Otago scientists could help scientists diagnose and treat a relapsing form of human malaria.

Getting to zero malaria cases in zanzibar
New research led by the Johns Hopkins Center for Communication Programs, Ifakara Health Institute and the Zanzibar Malaria Elimination Program suggests that a better understanding of human behavior at night -- when malaria mosquitoes are biting -- could be key to preventing lingering cases.

Widely used malaria treatment to prevent malaria in pregnant women
A global team of researchers, led by a research team at the Liverpool School of Tropical Medicine (LSTM), are calling for a review of drug-based strategies used to prevent malaria infections in pregnant women, in areas where there is widespread resistance to existing antimalarial medicines.

Protection against Malaria: A matter of balance
A balanced production of pro and anti-inflammatory cytokines at two years of age protects against clinical malaria in early childhood, according to a study led by ISGlobal, an institution supported by ''la Caixa'' Foundation.

The math of malaria
A new mathematical model for malaria shows how competition between parasite strains within a human host reduces the odds of drug resistance developing in a high-transmission setting.

Read More: Malaria News and Malaria Current Events is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to