Will lockdown loneliness make us loners?

June 10, 2020

London, 10 June 2020 - Over the past few months at least half of the world's population has been affected by some form of lockdown due to COVID-19, and many of us are experiencing the impact of social isolation. Loneliness affects both mental and physical health, but counterintuitively it can also result in a decreased desire for social interaction. To understand the mechanics of this paradox, UCL researchers based at the Wolfson Institute and the Sainsbury Wellcome Centre investigated social behaviour in zebrafish. Their results are published in eLife.

Most zebrafish demonstrate pro-social behaviour, but approximately 10% are 'loner' fish who are averse to social cues and demonstrate different brain activity than their pro-social siblings. However, even typically social zebrafish avoid social interaction after a period of isolation. PhD students Hande Tunbak and Mireya Vazquez-Prada, Postdoctoral Research Fellow Thomas Ryan, Dr Adam Kampff and Sir Henry Dale Wellcome Fellow Elena Dreosti set out to test whether the brain activity of isolated zebrafish mimics that of loner fish or whether other forces were at play.

To investigate the effects of isolation, the researchers isolated typically social zebrafish from other fish for a period of two days and then compared their brain activity to zebrafish who demonstrated aversion to social interaction without having been isolated. The isolated fish demonstrated sensitivity to stimuli and had increased activity in brain regions related to stress and anxiety. These effects of isolation were quickly overcome when the fish received a drug that reduces anxiety.

The differences between loner fish and their siblings were found mostly in the hypothalamus, the region of the brain responsible for social rewards. The loner fish hypothalamus did not demonstrate the same pattern of activation during social exposure as its typical counterparts, indicating that loner fish do not experience rewards in the same way as typical fish during social interactions.

By contrast, 'lonely' fish--those that demonstrated typical social behaviour and were isolated--demonstrated hypersensitivity to stimuli and activation of brain regions associated with stress and anxiety. Lonely fish experienced actively negative outcomes from social interaction whereas loner fish simply did not experience reward.

"A detailed view of the zebrafish brain can provide important clues for all of us currently experiencing the effects of social isolation," says Dr Elena Dreosti. Our understanding of the neural mechanisms of social behaviour are limited, but we do know that zebrafish and humans share a fundamental drive for social interaction that is controlled by similar brain structures. Although human behaviour is much more complex, understanding how this basic social drive arises--and how it is affected by isolation--is a necessary step towards understanding the impact of the social environment on human brains and behaviour. The zebrafish, which is completely transparent throughout early development, offers neuroscientists a detailed view of its brain circuitry.

We won't all be loners after lockdown, but we will be anxious upon returning to our normal social lives. As we emerge from lockdown, we should be aware of this new sensitivity and anxiety, but recognise that overcoming it is necessary for returning to a normal, healthy, social existence.
Read the full paper in eLife. https://elifesciences.org/articles/55863

DOI: 10.7554/eLife.55863

Contact: Hallie Detrick h.detrick@ucl.ac.uk

Communications Manager, Sainsbury Wellcome Centre, UCL

About UCL - London's Global University

UCL is a diverse community with the freedom to challenge and think differently.

Our community of more than 41,500 students from 150 countries and over 12,500 staff pursues academic excellence, breaks boundaries and makes a positive impact on real world problems.

We are consistently ranked among the top 10 universities in the world and are one of only a handful of institutions rated as having the strongest academic reputation and the broadest research impact.

We have a progressive and integrated approach to our teaching and research - championing innovation, creativity and cross-disciplinary working. We teach our students how to think, not what to think, and see them as partners, collaborators and contributors.

For almost 200 years, we are proud to have opened higher education to students from a wide range of backgrounds and to change the way we create and share knowledge.

We were the first in England to welcome women to university education and that courageous attitude and disruptive spirit is still alive today. We are UCL.

http://www.ucl.ac.uk| Follow @uclnews on Twitter | Watch our YouTube channel | Listen to UCL podcasts on SoundCloud | Find out what's on at UCL Minds | #MadeAtUCL

Find out how UCL is helping lead the global fight against COVID-19 http://www.ucl.ac.uk/covid-19-research

About the Wolfson Institute

The Wolfson Institute for Biomedical Research (WIBR) was established at UCL in 1995 for the pursuit of excellence in translational biomedical research. A member of the Division of Medicine, the department's primary focus is on excellence in basic neuroscience research and its application to mental health and disease. The WIBR is a key hub within the rich environment of the UCL neuroscience community.

About the Sainsbury Wellcome Centre

The Sainsbury Wellcome Centre (SWC) brings together outstanding experimental neuroscientists who work closely with theorists at the Gatsby Computational Neuroscience Unit (GCNU) to generate and test conceptual frameworks that explain how neural circuits give rise to the fundamental processes underpinning adaptive, flexible behaviour, including perception, memory, expectation, cognition, decisions and action.

The SWC fosters dialogue and collaboration between neuroscientists from within UCL and beyond. Our research environment, international PhD programme, and specialised courses in experimental and computational techniques are designed to equip the next generation of neuroscientists with the knowledge and tools to tackle the big questions in neuroscience.

Sainsbury Wellcome Centre

Related Stress Articles from Brightsurf:

Stress-free gel
Researchers at The University of Tokyo studied a new mechanism of gelation using colloidal particles.

Early life stress is associated with youth-onset depression for some types of stress but not others
Examining the association between eight different types of early life stress (ELS) and youth-onset depression, a study in JAACAP, published by Elsevier, reports that individuals exposed to ELS were more likely to develop a major depressive disorder (MDD) in childhood or adolescence than individuals who had not been exposed to ELS.

Red light for stress
Researchers from the Institute of Industrial Science at The University of Tokyo have created a biphasic luminescent material that changes color when exposed to mechanical stress.

How do our cells respond to stress?
Molecular biologists reverse-engineer a complex cellular structure that is associated with neurodegenerative diseases such as ALS

How stress remodels the brain
Stress restructures the brain by halting the production of crucial ion channel proteins, according to research in mice recently published in JNeurosci.

Why stress doesn't always cause depression
Rats susceptible to anhedonia, a core symptom of depression, possess more serotonin neurons after being exposed to chronic stress, but the effect can be reversed through amygdala activation, according to new research in JNeurosci.

How plants handle stress
Plants get stressed too. Drought or too much salt disrupt their physiology.

Stress in the powerhouse of the cell
University of Freiburg researchers discover a new principle -- how cells protect themselves from mitochondrial defects.

Measuring stress around cells
Tissues and organs in the human body are shaped through forces generated by cells, that push and pull, to ''sculpt'' biological structures.

Cellular stress at the movies
For the first time, biological imaging experts have used a custom fluorescence microscope and a novel antibody tagging tool to watch living cells undergoing stress.

Read More: Stress News and Stress Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.