New in Ethics and Human Research

June 10, 2020

Early-View article: Why Challenge Trials of SARS-CoV-2 Vaccines Could be Ethical Despite Risk of Severe Adverse Events\

Nir Eyal

Human challenge trials to test the efficacy of vaccine candidates against SARS?CoV?2, the novel coronavirus behind Covid?19, could save considerable time and many lives. But they may initially seem unethical because they expose healthy volunteers to a live virus that is killing many people and for which no cure exists. This article argues that this is not the correct test of their ethics. The correct test is comparative. And in the special circumstances of the Covid?19 pandemic, human challenge trials meet the correct test better than standard efficacy testing would. Eyal directs the Center or Population-Level Bioethics at Rutgers University and is a professor at the university.

Early-view article: Equitably Sharing the Benefits and Burdens of Research: Covid-19 Raises the Stakes

Carl H. Coleman

One of the central principles of research ethics is that the benefits and burdens of research with human participants should be equitably distributed. This principle has important implications for questions about where research will be conducted, how participants will be recruited, what questions will be investigated, and who will control the distribution of any innovations that result. In the rush to initiate clinical trials of treatments and vaccines for Covid?19, careful attention to these questions is particularly important. If clinical trials are not designed with equity considerations in mind, the response to the pandemic may exacerbate disparities in health status between population groups. This article calls for an international governance system to oversee access to Covid-19 vaccines and treatments. Coleman is a professor of law at Seton Hall University School of Law

May-June 2020 issue:

Justice and Domestic Health Research

The Importance of Engaging Children in Research Decision-Making: A Preliminary Mixed-Methods Study

Data Safety Monitoring during Covid-19: Keep on Keeping On

Adolescent and Parent Perceptions about Participation in Biomedical Sexual Health Trials

Genomics and Infectious Diseases: Expert Perspectives on Public Health Considerations regarding Actionability and Privacy

IRB Policies for Obtaining Informed Consent from Non-English-Speaking People
For more information, contact:

Susan Gilbert
Director of Communications
The Hastings Center
845-424-4040 x 244

The Hastings Center

Related Clinical Trials Articles from Brightsurf:

Nearly 1 in 5 cancer patients less likely to enroll in clinical trials during pandemic
A significant portion of cancer patients may be less likely to enroll in a clinical trial due to the ongoing coronavirus pandemic.

COVID-19 clinical trials lack diversity
Despite disproportionately higher rates of COVID-19 infection, hospitalization and death among people of color, minority groups are significantly underrepresented in COVID-19 clinical trials.

Why we should trust registered clinical trials
In a time when we have to rely on clinical trials for COVID-19 drugs and vaccines, a new study brings good news about the credibility of registered clinical trials.

Inclusion of children in clinical trials of treatments for COVID-19
This Viewpoint discusses the exclusion of children from coronavirus disease 2019 (COVID-19) clinical trials and why that could harm treatment options for children.

Review evaluates how AI could boost the success of clinical trials
In a review publishing July 17, 2019 in the journal Trends in Pharmacological Sciences, researchers examined how artificial intelligence (AI) could affect drug development in the coming decade.

Kidney patients are neglected in clinical trials
The exclusion of patients with kidney diseases from clinical trials remains an unsolved problem that hinders optimal care of these patients.

Clinical trials beginning for possible preeclampsia treatment
For over 20 years, a team of researchers at Lund University has worked on developing a drug against preeclampsia -- a serious disorder which annually affects around 9 million pregnant women worldwide and is one of the main causes of death in both mothers and unborn babies.

Underenrollment in clinical trials: Patients not the problem
The authors of the study published this month in the Journal of Clinical Oncology investigated why many cancer clinical trials fail to enroll enough patients.

When designing clinical trials for huntington's disease, first ask the experts
Progress in understanding the genetic mutation responsible for Huntington's disease (HD) and at least some molecular underpinnings of the disease has resulted in a new era of clinical testing of potential treatments.

New ALS therapy in clinical trials
New research led by Washington University School of Medicine in St.

Read More: Clinical Trials News and Clinical Trials Current Events is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to