Oncotarget: The role of EGFR mutations in predicting recurrence in lung adenocarcinoma

June 10, 2020

into the factors affecting recurrence, particularly tumor molecular genetics such as EGFR mutations, is needed.

These authors conducted a single-center retrospective study of 282 patients with early or locally advanced lung adenocarcinoma, with or without EGFR mutations, who underwent definitive therapy.

Then they assessed recurrence, stage at recurrence, time to recurrence, and progression-free survival.

However, among those who recurred, EGFR-mutated lung cancer had increased rates of metastatic recurrence compared to EGFR-wildtype disease.

Dr. Victoria Villaflor from The Division of Hematology-Oncology, as well as The Robert H. Lurie Comprehensive Cancer Center of Northwestern University in Chicago, Illinois, said, "According to the World Health Organization (WHO), lung cancer is the most common cause of cancer and cancer-related mortality in both men and women worldwide."

Lung cancer can be divided into small cell lung cancer, which accounts for ~15% of cases, and non-small cell lung cancer, which accounts for ~85% of cases.

Despite definitive therapy, 30 55% of patients with early NSCLC will eventually experience disease recurrence and die of their disease.

With tumor molecular genetics at the forefront of precision medicine, subclassification of NSCLC based on EGFR mutation status has been paramount for predicting response to EGFR targeted therapies in unresectable advanced and metastatic disease.

Despite advances in those with unresectable disease, little is known about the prognostic implications of EGFR mutation status in early and locally advanced NSCLC amenable to definitive therapy.

This single-institution retrospective study aims to better understand the implications of EGFR mutation status on localized or locally advanced NSCLC amenable to definitive therapy.

"This single-institution retrospective study aims to better understand the implications of EGFR mutation status on localized or locally advanced NSCLC amenable to definitive therapy"

The Villaflor Research Team concluded in their OncotargetResearch Paper, "this study suggests EGFR mutation as an important marker for predicting metastatic disease recurrence and highlights the growing need for precision medicine in early and locally advanced NSCLC. Early identification of these recurrences is paramount given the improved post-relapse survival observed in this population. A better understanding of the factors leading to relapse rates using prospective, multi-center investigations could help guide future surveillance practices, identify those patients at higher risk, and ultimately extend patient survival."

Impact Journals LLC

Related Lung Cancer Articles from Brightsurf:

State-level lung cancer screening rates not aligned with lung cancer burden in the US
A new study reports that state-level lung cancer screening rates were not aligned with lung cancer burden.

The lung microbiome may affect lung cancer pathogenesis and prognosis
Enrichment of the lungs with oral commensal microbes was associated with advanced stage disease, worse prognosis, and tumor progression in patients with lung cancer, according to results from a study published in Cancer Discovery, a journal of the American Association for Cancer Research.

New analysis finds lung cancer screening reduces rates of lung cancer-specific death
Low-dose CT screening methods may prevent one death per 250 at-risk adults screened, according to a meta-analysis of eight randomized controlled clinical trials of lung cancer screening.

'Social smokers' face disproportionate risk of death from lung disease and lung cancer
'Social smokers' are more than twice as likely to die of lung disease and more than eight times as likely to die of lung cancer than non-smokers, according to research presented at the European Respiratory Society International Congress.

Lung cancer therapy may improve outcomes of metastatic brain cancer
A medication commonly used to treat non-small cell lung cancer that has spread, or metastasized, may have benefits for patients with metastatic brain cancers, suggests a new review and analysis led by researchers at St.

Cancer mortality continues steady decline, driven by progress against lung cancer
The cancer death rate declined by 29% from 1991 to 2017, including a 2.2% drop from 2016 to 2017, the largest single-year drop in cancer mortality ever reported.

Cancer-sniffing dogs 97% accurate in identifying lung cancer, according to study in JAOA
The next step will be to further fractionate the samples based on chemical and physical properties, presenting them back to the dogs until the specific biomarkers for each cancer are identified.

Lung transplant patients face elevated lung cancer risk
In an American Journal of Transplantation study, lung cancer risk was increased after lung transplantation, especially in the native (non-transplanted) lung of single lung transplant recipients.

Proposed cancer treatment may boost lung cancer stem cells, study warns
Epigenetic therapies -- targeting enzymes that alter what genes are turned on or off in a cell -- are of growing interest in the cancer field as a way of making a cancer less aggressive or less malignant.

Are you at risk for lung cancer?
This question isn't only for people who've smoked a lot.

Read More: Lung Cancer News and Lung Cancer Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.