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Kids with headache after stroke might be at risk for another stroke

June 12, 2019

A new study has found a high incidence of headaches in pediatric stroke survivors and identified a possible association between post-stroke headache and stroke recurrence. Headache developed in over a third of participating children, on average six months after the stroke. Fifteen percent of patients suffered another stroke, typically in the first six to 12 months after the initial stroke. In the study, most children who experienced headache during stroke recurrence also had other associated neurologic symptoms, mostly weakness of one side of the body (hemiparesis) or facial asymmetry and brain malfunction (encephalopathy). Findings were published in Neurology: Clinical Practice, a journal of the American Academy of Neurology.

"In our study, post-stroke headache was more common in patients who experienced another stroke, which suggests that it might be a risk factor for stroke recurrence," says co-lead author Jonathan Kurz, MD, PhD, pediatric neurologist in the Ruth D. & Ken M. Davee Pediatric Neurocritical Care Program at Ann & Robert H. Lurie Children's Hospital of Chicago, and Instructor of Pediatrics at Northwestern University Feinberg School of Medicine. "More research is needed to test this hypothesis, and it remains unclear if headache treatment would lower the risk for stroke recurrence. Children with post-stroke headache might need closer observation or different strategies to prevent another stroke. This requires more study."

The risk of stroke from birth through age 19 years is about five per 100,000 children, according to the Children's Hemiplegia and Stroke Association (CHASA). In children, the risk of stroke is highest in the first year of life, especially during the perinatal period (a few weeks before and after birth).

The study included 115 children, aged 30 days to 18 years, who had survived a stroke. Thirty-six percent of these children experienced headache that occurred more than 30 days after their stroke. Children with post-stroke headache tended to be survivors of a stroke caused by artery disease (arteriopathy). Of these children, over half had headache severe enough to go to the emergency department, and 81 percent were admitted to the hospital for headache.

"Earlier recognition post-stroke headache in children may improve the care, recovery and quality of life in pediatric stroke survivors," says Dr. Kurz. "Further research will help us better understand the causes of post-stroke headache and its association with stroke recurrence."
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Funding for this study came from Ruth D. & Ken M. Davee Pediatric Neurocritical Care Program at Lurie Children's.

Research at Ann & Robert H. Lurie Children's Hospital of Chicago is conducted through the Stanley Manne Children's Research Institute. The Manne Research Institute is focused on improving child health, transforming pediatric medicine and ensuring healthier futures through the relentless pursuit of knowledge. Lurie Children's is ranked as one of the nation's top children's hospitals by U.S. News & World Report. It is the pediatric training ground for Northwestern University Feinberg School of Medicine. Last year, the hospital served more than 212,000 children from 49 states and 51 countries.

Ann & Robert H. Lurie Children's Hospital of Chicago

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