Nav: Home

What are risk factors for dementia after intracerebral hemorrhage?

June 13, 2016

Larger hematoma size and location were risk factors associated with dementia after an intracerebral hemorrhage when a blood vessel in the brain bursts, according to an article published online by JAMA Neurology.

Intracerebral hemorrhage (ICH) accounts for about 15 percent of all strokes and about 50 percent of stroke-related death and disability worldwide. Progressive cognitive decline is frequent after ICH but there is limited understanding of its risk factors.

Alessandro Biffi, M.D., of Massachusetts General Hospital, Boston, and coauthors studied patients who had ICH from 2006 through 2013. There were 738 patients (average age about 74) without pre-ICH dementia who were included in the analyses of early post-ICH dementia within six months. There were 435 patients included in the analyses of delayed post-ICH dementia after six months. The authors used a telephone-based tool to assess cognitive performance.

The study reports that 140 (19 percent) patients developed dementia within six months and 139 developed dementia after six months. Larger size of the hematoma (the clotted blood) and location in the brain were associated with risk for early post-ICH dementia within six months. Educational level, mood symptoms and the severity of white matter disease were associated with risk for delayed post-ICH dementia after six months.

The authors note study limitations include the use of telephone-based cognitive assessments rather than in-person interviews.

"These findings are of immediate clinical relevance to health care professionals and patients who have experienced ICH. Assuming replication of our findings in future studies, adequate communication of the risk of cognitive decline (especially beyond the immediate period after ICH) will represent a critical issue for physicians, their patients who have experienced ICH, and patients' family and caregivers," the authors conclude.

(JAMA Neurol. Published online June 13, 2016. doi:10.1001/jamaneurol.2016.0955. Available pre-embargo to the media at http://media.jamanetwork.com.)

Editor's Note: The article contains funding/support disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.

Editorial: Dementia After Intracerebral Hemorrhage

"The study by Biffi et al provides valuable insight into the frequency of early and late dementia after ICH as well as the possible etiologic factors. The frequency of dementia reported in this study emphasizes that it may be helpful to routinely incorporate questions about cognitive status and functional recovery after ICH. For delayed dementia, in particular, it remains unclear whether post-ICH cognitive decline is truly secondary to the ICH itself or if hemorrhage was perhaps a symptom of an ongoing process that also led to cognitive decline," Rebecca F. Gottesman, M.D., Ph.D., of Johns Hopkins University, Baltimore, writes in a related editorial.

(JAMA Neurol. Published online June 13, 2016. doi:10.1001/jamaneurol.2016.1538. Available pre-embargo to the media at http://media.jamanetwork.com.)

Editor's Note: The article contains conflict of interest disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.
-end-
Media Advisory: To contact corresponding study author Alessandro Biffi, M.D., call Terri Ogan at 617-726-0954 or email togan@partners.org. To contact corresponding editorial author Rebecca F. Gottesman, M.D., Ph.D., call Vanessa McMains at 410-502-9410 or email vmcmain1@jhmi.edu.

The JAMA Network Journals

Related Dementia Articles:

Digital solutions for dementia care
Telehealth delivery of dementia care in the home can be as effective as face-to-face home visit services if carers and recipients take advantage of the technologies available, Australian researchers say.
Despite a marked reduction in the prevalence of dementia, the number of people with dementia is set to double by 2050 according to new Alzheimer Europe report
Today, at a European Parliament lunch debate, Alzheimer Europe launched a new report presenting the findings of its collaborative analysis of recent prevalence studies and setting out updated prevalence rates for dementia in Europe.
Inflammatory marker linked to dementia
Higher levels of an inflammatory marker, sCD14, were associated with brain atrophy, cognitive decline and dementia in two large heart studies.
How likely do you think you are to develop dementia?
A poll suggests almost half of adults ages 50 to 64 believe they're likely to develop dementia.
Latest issue of Alzheimer's & Dementia
Predicting heart disease might also be a warning sign for Alzheimer's; A new way to think about the environment and Alzheimer's research; Most dementia patients don't receive care from physicians who specialize in brain health.
What multilingual nuns can tell us about dementia
A strong ability in languages may help reduce the risk of developing dementia, says a new University of Waterloo study.
Brain changes may help track dementia, even before diagnosis
Even before a dementia diagnosis, people with mild cognitive impairment may have different changes in the brain depending on what type of dementia they have, according to a study published in the September 11, 2019, online issue of Neurology®, the medical journal of the American Academy of Neurology.
Could marriage stave off dementia?
Dementia and marital status could be linked, according to a new Michigan State University study that found married people are less likely to experience dementia as they age.
Migraine diagnoses positively associated with all-cause dementia
Several studies have recently focused on the association between migraine headaches and other headaches and dementia and found a positive migraine-dementia relationship.
Apathy: The forgotten symptom of dementia
Apathy is the most common neuropsychiatric symptom of dementia, with a bigger impact on function than memory loss -- yet it is under-researched and often forgotten in care.
More Dementia News and Dementia Current Events

Trending Science News

Current Coronavirus (COVID-19) News

Top Science Podcasts

We have hand picked the top science podcasts of 2020.
Now Playing: TED Radio Hour

Listen Again: Reinvention
Change is hard, but it's also an opportunity to discover and reimagine what you thought you knew. From our economy, to music, to even ourselves–this hour TED speakers explore the power of reinvention. Guests include OK Go lead singer Damian Kulash Jr., former college gymnastics coach Valorie Kondos Field, Stockton Mayor Michael Tubbs, and entrepreneur Nick Hanauer.
Now Playing: Science for the People

#562 Superbug to Bedside
By now we're all good and scared about antibiotic resistance, one of the many things coming to get us all. But there's good news, sort of. News antibiotics are coming out! How do they get tested? What does that kind of a trial look like and how does it happen? Host Bethany Brookeshire talks with Matt McCarthy, author of "Superbugs: The Race to Stop an Epidemic", about the ins and outs of testing a new antibiotic in the hospital.
Now Playing: Radiolab

Dispatch 6: Strange Times
Covid has disrupted the most basic routines of our days and nights. But in the middle of a conversation about how to fight the virus, we find a place impervious to the stalled plans and frenetic demands of the outside world. It's a very different kind of front line, where urgent work means moving slow, and time is marked out in tiny pre-planned steps. Then, on a walk through the woods, we consider how the tempo of our lives affects our minds and discover how the beats of biology shape our bodies. This episode was produced with help from Molly Webster and Tracie Hunte. Support Radiolab today at Radiolab.org/donate.