Nav: Home

Genetic variants linked to higher BMI may be protective against Parkinson disease

June 13, 2017

Genetic variants linked to higher body mass index (BMI) are associated with lower risk of Parkinson disease, according to a study published by Nicholas Wood and colleagues from the University College London, UK, in PLOS Medicine.

The researchers used a Mendelian randomization approach to examine whether genetic variants linked to higher BMI were also associated with risk of Parkinson disease. The associations between the genetic variants and BMI were obtained from the GIANT consortium and the relationship between the same genetic variants and Parkinson disease was ascertained from a recent meta-analysis that included 13,708 cases of Parkinson disease and 95,282 controls. The researchers observed that genetic risk expected to confer a lifetime exposure of 5-kg/m2 higher BMI was associated with an 18% lower risk of Parkinson disease (OR 0.82, 95% CI 0.69-0.98). A limitation of the approach is that individuals who have higher BMI have a higher risk of earlier mortality, and therefore individuals with lower BMI may be over-represented amongst individuals diagnosed with Parkinson disease. This "frailty effect" could at least partially account for the estimated association.

The authors say: "Although our results suggest that higher BMI is potentially protective against PD, the negative health impacts of raising BMI are likely to be significant, and should be taken into account."
-end-
Research Article

Funding:

The authors received no specific funding for this work. Other individual financial disclosures: AJN is funded by Parkinson's UK (ref F1201). DAK is supported by an MB PhD Award from the International Journal of Experimental Pathology. GH, PCH, GDS and DAL work in a unit that receives funding from the University of Bristol and the UK Medical Research Council (MC_UU_1201/1 and MC_UU_1201/5). DAL is a National Institute of Health Research Senior Investigator (NF-SI-0166-10196). PCH is supported by CRUK Population Research Postdoctoral Fellowship C52724/A20138. PAL receives funding from the MRC (MR/N026004/1 and MR/L010933/1). MN, ASi, AN and TRP participation in this study was supported in part by the Intramural Research Program of the National Institute on Aging, NIH. University College London Hospitals and University College London receive support from the Department of Health's National Institute for Health Research (NIHR) Biomedical Research Centres (BRC). NWW is an NIHR senior Investigator and receives support from the JPND-MRC Comprehensive Unbiased Risk factor Assessment for Genetics and Environment in Parkinson's disease (COURAGE). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Competing Interests:

AJN reports: grants from Parkinson's UK, Élan/Prothena Pharmaceuticals, GE Healthcare; shares in LifeLab Ltd; advisory board membership for myHealthPal; honoraria from Office Octopus, Henry Stewart Talks, and Britannia Pharmaceuticals Ltd, all outside of the submitted work. PAL reports grants from MRC, BBSRC, National Institutes of Health, Michael J. Fox Foundation, personal fees from Astex Pharmaceuticals, outside the submitted work. TF reports grants from Michael J Fox Foundation, grants from Brain Research Trust, grants from European Union FP7, grants from John Black Charitable Foundation, personal fees from Medtronic, personal fees from BIAL, personal fees from Profile Pharma, personal fees from Brittania, all outside the submitted work. ASc reports grants from GE Healthcare, outside the submitted work. AJL reports personal fees from Britannia Pharmaceuticals Ltd, BIAL Portela, Profile Pharma Ltd, Teva, Lundbeck, Roche, UCB, NeuroDerm, Nordicinfu Care, Decision Resources, all outside of the submitted work. GDS is a member of the Editorial Board of PLOS Medicine. Mike Nalls participated in this work as a paid contractor/consultant for Kelly Government Services. DAL reports grants from UK Medical Research Council, during the conduct of the study; grants from Medical Research council, grants from Wellcome Trust, grants from European Research Council, grants from Roche Diagnostics, grants from Medtronic, grants from Ferring Pharmaceuticals, outside the submitted work. DAK, GH, ASi, AN, EDP-F, JH, NP, TRP, NWW, MN report no relevant disclosures.

Citation:

Noyce AJ, Kia DA, Hemani G, Nicolas A, Price TR, De Pablo-Fernandez E, et al. (2017) Estimating the causal influence of body mass index on risk of Parkinson disease: A Mendelian randomisation study. PLoS Med 14(6): e1002314. https://doi.org/10.1371/journal.pmed.1002314

Author Affiliations:

Department of Molecular Neuroscience, UCL Institute of Neurology, University College London, London, United Kingdom
Centre for Neuroscience and Trauma, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom
MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom
School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom
Laboratory for Neurogenetics, National Institute on Aging National Institutes of Health, Bethesda, Maryland, United States of America
School of Pharmacy, University of Reading, Reading, United Kingdom
Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, University College London, London, United Kingdom
Department of Clinical Neurosciences, UCL Institute of Neurology, University College London, London, United Kingdom
Data Technica International, Glen Echo, Maryland, United States of America
Department of Medical Statistics, London School of Hygiene & Tropical Medicine, London, United Kingdom

IN YOUR COVERAGE PLEASE USE THIS URL TO PROVIDE ACCESS TO THE FREELY AVAILABLE PAPER:

http://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1002314

PLOS

Related Genetic Variants Articles:

Genetic variants with possible positive implications for lifestyle
A German and British research team lead by the Technical University of Munich (TUM) has examined the interplay between genetics, cardiovascular disease and educational attainment in a major population study.
Managing ovarian cancer risk in women with BRCA1/2 genetic variants
A new review to help physicians manage the risk of ovarian cancer in women who carry the BRCA1/2 gene mutations is published in CMAJ.
Researchers find anorexia genetic variants, redefine it as metabolic and psychiatric
The large-scale genome-wide association study, led by UNC's Cynthia M.
Study of multiethnic genomes identifies 27 genetic variants associated with disease
Researchers have identified 27 new genomic variants associated with conditions such as blood pressure, type II diabetes, cigarette use and chronic kidney disease in diverse populations.
Genetic variants that protect against obesity could aid new weight loss medicines
Around four million people in the UK carry genetic variants that protect them from obesity, type 2 diabetes and heart disease, suggests new research from the University of Cambridge.
More Genetic Variants News and Genetic Variants Current Events

Best Science Podcasts 2019

We have hand picked the best science podcasts for 2019. Sit back and enjoy new science podcasts updated daily from your favorite science news services and scientists.
Now Playing: TED Radio Hour

Erasing The Stigma
Many of us either cope with mental illness or know someone who does. But we still have a hard time talking about it. This hour, TED speakers explore ways to push past — and even erase — the stigma. Guests include musician and comedian Jordan Raskopoulos, neuroscientist and psychiatrist Thomas Insel, psychiatrist Dixon Chibanda, anxiety and depression researcher Olivia Remes, and entrepreneur Sangu Delle.
Now Playing: Science for the People

#537 Science Journalism, Hold the Hype
Everyone's seen a piece of science getting over-exaggerated in the media. Most people would be quick to blame journalists and big media for getting in wrong. In many cases, you'd be right. But there's other sources of hype in science journalism. and one of them can be found in the humble, and little-known press release. We're talking with Chris Chambers about doing science about science journalism, and where the hype creeps in. Related links: The association between exaggeration in health related science news and academic press releases: retrospective observational study Claims of causality in health news: a randomised trial This...