New analytical technology to quantify anti-cancer drugs inside cancer cellsJune 14, 2016
University of Oklahoma researchers will apply a new analytical technology that could ultimately provide a powerful tool for improved treatment of cancer patients in Oklahoma and beyond. Using mass spectrometry, an analytical instrument for sensitive detection and accurate identification of molecules, the team will quantitate the amount of anti-cancer drugs present in individual cancer cells, including those in bladder cancer cells isolated from patients undergoing chemotherapy. The method will provide a means to establish ideal dosing regimens that delivers effective chemotherapeutic concentrations to patients with minimal toxicities.
Anthony Burgett and Zhibo Yang, assistant professors in the Department of Chemistry and Biochemistry in the OU College of Arts and Sciences, and affiliates of the Stephenson Cancer Center, in collaboration with Jonathan E. Heinlen, M.D., assistant professor in the Department of Urology at the OU Health Sciences Center and a Stephenson Cancer Center researcher, will fully develop the novel first-in-class mass spectrometric technology--the Single Probe--capable of performing single-cell mass spectrometry of compounds inside of living single cancer cells as a bioanalytical method to improve efficacy and toxicities of chemotherapy in patients.
"One clear lesson from scientific progress is that new technologies often lead to major advances. This new single cancer cell mass spectrometry analysis could propel us forward to a new frontier in biological analysis, and we are excited to see where this technology, with its possible scientific and biomedical applications, could lead," said Burgett.
Currently, there are no clinical bioanalytical methods capable of determining the concentration of chemotherapeutic agents inside of a patient's individual cancer cells. A single-cell analysis method that could also assess the effectiveness of the patient-administered chemotherapeutic on the health of the individual cancer cells would give real-time relevant information about the therapeutic efficacy. Using the Single-probe, a miniaturized device with a sampling tip smaller than a cell, anti-cancer drugs inside a cancer cell can be extracted and quantified using mass spectrometry.
"Bladder cancer is a horrible disease with high costs of treatment--financially and in terms of quality of life of patients," said Dr. Heinlen. "Typically, we only know the effects of treatment weeks to months after the administration of cytotoxic chemotherapy. This technique could possibly give us insight into treatment efficacy as soon as the dose is administered. Those patients who have undergone several cycles of chemotherapy only to find the treatment was ineffective would see this as a major benefit."
If successful, this innovative research will produce a method capable of quantitating the intracellular level of a standard-of-care chemotherapeutic agent in patient single cancer cells for the first time. Further, this project would mark the first time a single-cell mass spectrometry method has been successfully used in a clinical setting, and this advancement would provide a potentially novel and powerful tool for the improved treatment of cancer patients in the state of Oklahoma and beyond.
University of Oklahoma
Related Chemotherapy Articles:
A chemotherapy drug used to treat brain cancer may increase vulnerability to depression by stopping new brain cells from growing, according to a new King's College London study out today in Translational Psychiatry.
A Washington State University researcher has documented epigenetic changes in the sperm of men who underwent chemotherapy in their teens.
A brain-boosting protein plays an important role in how well people respond to chemotherapy, researchers report at the ESMO Asia 2016 Congress in Singapore.
It is known from previous research that the ER-beta estrogen receptor often has a protective effect.
A team of UCLA bioengineers has demonstrated that its technology may go a long way toward overcoming the challenges of treatment for acute lymphoblastic leukemia, among the most common types of cancer in children, and has the potential to help doctors personalize drug doses.
Two bacterial species that inhabit the human gut activate immune cells to boost the effectiveness of a commonly prescribed anticancer drug, researchers report Oct.
For the last three years the research team has been working on the development of a so-called biomarker to predict treatment effectiveness.
For the first time, researchers have discovered that some leukemia cells harvest energy resources from normal cells during chemotherapy, helping the cancer cells not only to survive, but actually thrive, after treatment.
Researchers at Haukeland University Hospital in Bergen, Norway have combined a laboratory ultrasound technique called 'sonoporation' with the commercially-available chemotherapy compound Gemcitabine to increase the porosity of pancreatic cells with microbubbles and to help get the drug into cancer cells where it is needed.
The addition of high doses of a form of vitamin A could help make chemotherapy more successful in treating pancreatic cancer, according to an early study by Queen Mary University of London.
Related Chemotherapy Reading:
The Chemotherapy Survival Guide: Everything You Need to Know to Get Through Treatment
by Judith McKay (Author), Tammy Schacher RN OCN MSN (Author)
When you're facing cancer treatment, it's easy to feel overwhelmed and alone. Between the hospital or clinic environment and the medical terminology used by doctors and health care professionals, you may feel as though you've entered a foreign country.
Written by two experienced oncology nurses, this compassionate and comprehensive guide explains in plain English everything you need to know about your treatment, including what you can expect at each stage of chemotherapy and what you can do to prevent or minimize side effects. Packed with practical suggestions, nutritional advice,... View Details
Physicians' Cancer Chemotherapy Drug Manual 2018
by Edward Chu (Author), Vincent T. DeVita Jr. (Author)
Completely revised and updated for 2018, the Physicians' Cancer Chemotherapy Drug Manual is an up-to-date guide to the latest information on standard therapy and recent advances in the field. Written by world-class experts in clinical cancer therapeutics, this essential reference provides a complete, easy-to-use catalogue of over 100 drugs and commonly used drug regimens--both on- and off-label--for the treatment of all the major cancers. View Details
Chemotherapy and Biotherapy Guidelines and Recommendations for Practice
by Martha Polovich (Author), MiKeala Olsen (Author), Kris Lefebvre (Author)
Order your copy of the fourth edition of the best-selling resource used by more than 101,000 healthcare professionals since 2009 and keep up-to-date on the latest chemotherapy, biotherapy, and targeted agents. This new edition of the Chemotherapy and Biotherapy Guidelines and Recommendations for Practice has been revised and updated to reflect the current procedures and practices in your specialty. You'll find that this latest edition incorporates a number of significant changes. To help you find the content and information that you need quickly and easily, the text has been reorganized and... View Details
Chemotherapy and Radiation For Dummies
by Alan P. Lyss (Author), Humberto Fagundes (Author), Patricia Corrigan (Author)
An informative, compassionate guide for cancer patients and their loved ones
Each year, more than 1 million people get treated for cancer, and most of these will undergo chemotherapy, radiation therapy, or both. This reassuring, optimistic guide helps people get a handle on treatment options and explains in plain English how chemotherapy and radiation therapy really work. It offers detailed advice on how to alleviate and cope with side effects-which range from hair loss to nausea to anemia-and describes how good nutrition, meditation, support groups, and other techniques and... View Details
Chemo: Secrets to Thriving: From someone who’s been there.
by Roxanne Brown (Author), Barbara Mastej (Contributor), John S. Link M.D. (Contributor)
The thought of chemotherapy can be overwhelming, but getting through it doesn’t have to be. Chemo: Secrets to Thriving helps lighten the load. In chronological order, step-by- step, you learn what might occur, why it happens, what you can do (with your doc’s approval), and who to contact for help. Chemo: Secrets to Thriving will be your friend, companion, and guide, giving you the resources to handle possible side effects and better manage your life during chemotherapy. Once you know the secrets in this book you may find yourself still able to enjoy life—and even thrive—while going... View Details
Stay Healthy During Chemo: The Five Essential Steps
by Mike Herbert ND (Author), Joseph Dispenza (Contributor)
Chemotherapy works to beat your cancer, but it also takes its own toll on your body and your health. During treatment, it is more important than ever to do what you can to keep yourself strong and healthy. The best way of doing that is to work with your body's innate healing powers.
This book offers a treasure chest of practical guidance for feeling good during chemo and beyond. And it does so through 5 basic steps, supporting you to:
Change your thinking and develop an attitude focused on healing.Detoxify with therapeutic baths to promote healing from the inside out.Eat the best... View Details
Physicians' Cancer Chemotherapy Drug Manual 2017
by Edward Chu (Author), Vincent T. DeVita Jr. (Author)
Completely revised and updated for 2017, the Physicians' Cancer Chemotherapy Drug Manual is an up-to-date guide to the latest information on standard therapy and recent advances in the field. Written by world-class experts in clinical cancer therapeutics, this essential reference provides a complete, easy-to-use catalogue of over 100 drugs and commonly used drug regimens--both on- and off-label--for the treatment of all the major cancers. View Details
What to Eat During Cancer Treatment: 100 Great-Tasting, Family-Friendly Recipes to Help You Cope
by Jeanne Besser (Author), Kristina Ratley (Author), Sheri Knecht (Author), Michele Szafranski (Author)
Winner: 2010 National Health Information Award, Gold; 2010 AM&P Snap/EXCEL Award, Silver
2010 Mom's Choice Award, Gold, Adult Books - Cooking, Food & Wine; 2009 Association TRENDS All Media Contest, Silver; Finalist: 2010 National Indie Excellent Award, Cookbooks; 2009 USA Best Book Award, Cookbooks - General ——— This cookbook contains 100 fast, flavorful recipes to help both patient and caregiver prepare satisfying meals to combat some of the side effects of treatment. Recipes are organized by side effects and include Brie and Apple Grilled Cheese to deal with nausea,... View Details
by Ralph W. Moss (Author)
A revealing critique of chemotherapy, this book looks objectively at chemo's successes and failures. View Details
Fighting Cancer With No Chemotherapy and Without Pharmaceuticals: No.1 in the Series: "Fighting Diseases Without Pharmaceuticals"
This book will teach you how to use natural foods and nutritional supplements to prevent, cure, or treat cancer, including cancer in general and many specific cancers as well.
Most of us know that what we eat and how much we eat is important. But do you know that there are natural, high-nutrition foods that can help you to avoid or substantially diminish the risk of you ever getting a serious or fatal disease, like cancer, without subjecting yourself to chemotherapy and without taking strong pharmaceutical drugs which so often either don’t solve the problem or have insidious... View Details