Flavored electronic cigarettes linked to possible cardiovascular disease

June 14, 2018

(Boston)--Could flavored electronic cigarettes (e-cigarettes) cause bodily harm?

There has been a rapid rise in e-cigarette use, partially due to flavoring additives in tobacco products and perception of less harm than traditional combustible cigarettes. Numerous studies have been done on the risks of e-cigarettes to lungs, but the risk to blood vessels and how flavorings can affect the body are largely unknown.

The dangers of combustible cigarettes on the cardiovascular system has been known for decades, however e-cigarettes have only been around since the early 2000s. Studies to determine whether e-cigarettes are dangerous to blood vessels have been done, but no study has looked directly at the flavored additives toxicity to blood vessels until now.

Researchers at Boston University School of Medicine (BUSM) looked at short-term effects of flavoring chemicals used in tobacco products like e-cigarettes on endothelial cells, cells that line the blood vessels. The researchers noticed that when blood vessels were exposed to flavoring additives, normally released chemicals to promote blood flow were decreased and increased inflammation, indicators of short-term toxicity. They also found that endothelial cells from smokers showed the same toxicity as those treated with flavoring chemicals.

"Our findings show that flavoring additives themselves were directly toxic to blood vessels and have adverse effects that may have relevance to cardiovascular toxicity long-term similar to combustible cigarettes," explained corresponding author Jessica Fetterman, PhD assistant professor of medicine at BUSM.

These findings appear in the journal Arteriosclerosis, Thrombosis, and Vascular Biology.
-end-
Funding supported by the National Heart, Lung and Blood Institute (NHLBI) and FDA Center for Tobacco Products (CTP) and an American Heart Association Mentored Clinical and Population Research Award 17MCPRP32650002 (JLF).

Boston University School of Medicine

Related Blood Vessels Articles from Brightsurf:

Biofriendly protocells pump up blood vessels
In a new study published today in Nature Chemistry, Professor Stephen Mann and Dr Mei Li from Bristol's School of Chemistry, together with Associate Professor Jianbo Liu and colleagues at Hunan University and Central South University in China, prepared synthetic protocells coated in red blood cell fragments for use as nitric oxide generating bio-bots within blood vessels.

Specific and rapid expansion of blood vessels
Upon a heart infarct or stroke, rapid restoration of blood flow, and oxygen delivery to the hypo perfused regions is of eminent importance to prevent further damage to heart or brain.

Flexible and biodegradable electronic blood vessels
Researchers in China and Switzerland have developed electronic blood vessels that can be actively tuned to address subtle changes in the body after implantation.

Lumpy proteins stiffen blood vessels of the brain
Deposits of a protein called ''Medin'', which manifest in virtually all older adults, reduce the elasticity of blood vessels during aging and hence may be a risk factor for vascular dementia.

Cancer cells take over blood vessels to spread
In laboratory studies, Johns Hopkins Kimmel Cancer Center and Johns Hopkins University researchers observed a key step in how cancer cells may spread from a primary tumor to a distant site within the body, a process known as metastasis.

Novel function of platelets in tumor blood vessels found
Scientists at Uppsala University have discovered a hitherto unknown function of blood platelets in cancer.

Blood vessels can make you fat, and yet fit
IBS scientists have reported Angiopoietin-2 (Angpt2) as a key driver that inhibits the accumulation of potbellies by enabling the proper transport of fatty acid into general circulation in blood vessels, thus preventing insulin resistance.

Brothers in arms: The brain and its blood vessels
The brain and its surrounding blood vessels exist in a close relationship.

Feeling the pressure: How blood vessels sense their environment
Researchers from the University of Tsukuba discovered that Thbs1 is a key extracellular mediator of mechanotransduction upon mechanical stress.

Human textiles to repair blood vessels
As the leading cause of mortality worldwide, cardiovascular diseases claim over 17 million lives each year, according to World Health Organization estimates.

Read More: Blood Vessels News and Blood Vessels Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.