Chubby children risk developing unfavorable lipid profile in childhood, UB study shows

June 15, 2000

SEATTLE -- University at Buffalo investigators have determined that children with a high body mass index (BMI), a measure of obesity, are likely to have high levels of triglycerides and low levels of protective cholesterol in childhood, dyslipidemia conditions that contribute to heart disease in adulthood.

The study ruled out low birth weight -- also thought to be associated with an increased risk of heart disease in adulthood -- as a risk factor for dyslipidemia in children.

Results of the study were presented here today (June 16) at the annual meeting of the Society for Epidemiologic Research.

"We think that one's lipid profile in adulthood may be directly related to the profile in childhood," said Jian Liu, a doctoral student in the UB Department of Social and Preventive Medicine and lead author on the study. "There may be some genetic factors that influence lipid profiles, but most of the influence comes from lifestyle factors.

"This study shows it is more important to look at body mass index than birth weight when assessing the potential for dyslipidemia in children." Every child should get plenty of exercise to maintain a healthy BMI, he added.

Liu and colleagues used data from the Third National Health and Nutrition Examination Survey (NHANES III) conducted in the United States from 1988-94 in their analysis.

The researchers assessed birth weight and BMI of 4,089 children between the ages of 4 and 11, and compared the relationship of these factors to total cholesterol, HDL cholesterol and triglycerides.

They found no statistical differences between weight at birth and total cholesterol and triglycerides in childhood. However, there were significant differences in levels of HDL, the protective cholesterol. Children who weighed less than 2,500 grams at birth had the lowest levels of HDL (55 mg/dl), while those with normal birth weight had the highest, an average of 58.5 mg/dl.

When birth weight and other potential confounding factors, such as maternal age and smoking during pregnancy, were taken into account, the analysis showed significant differences between children with a low and high BMI in levels of triglycerides and HDL. A BMI above the 75th percentile on the child BMI scale was considered high.

Children who fell into the high BMI group were found to have an average triglyceride reading of 117 mg/dl, compared to 95.2 mg/dl for those in the low BMI group. HDL cholesterol readings for high and low BMI group were 51.2 and 45.9 mg/dl, respectively. There was no significant difference in total cholesterol between the two groups.
-end-
Also contributing to this study were Germaine M. Buck, Ph.D., and John Weiner, Ph.D., of the UB Department of Social and Preventive Medicine.

University at Buffalo

Related Heart Disease Articles from Brightsurf:

Cellular pathway of genetic heart disease similar to neurodegenerative disease
Research on a genetic heart disease has uncovered a new and unexpected mechanism for heart failure.

Mechanism linking gum disease to heart disease, other inflammatory conditions discovered
The link between periodontal (gum) disease and other inflammatory conditions such as heart disease and diabetes has long been established, but the mechanism behind that association has, until now, remained a mystery.

New 'atlas' of human heart cells first step toward precision treatments for heart disease
Scientists have for the first time documented all of the different cell types and genes expressed in the healthy human heart, in research published in the journal Nature.

With a heavy heart: How men and women develop heart disease differently
A new study by researchers from McGill University has uncovered that minerals causing aortic heart valve blockage in men and women are different, a discovery that could change how heart disease is diagnosed and treated.

Heart-healthy diets are naturally low in dietary cholesterol and can help to reduce the risk of heart disease and stroke
Eating a heart-healthy dietary pattern rich in vegetables, fruits, whole grains, low-fat dairy products, poultry, fish, legumes, vegetable oils and nuts, which is also limits salt, red and processed meats, refined-carbohydrates and added sugars, is relatively low in dietary cholesterol and supports healthy levels of artery-clogging LDL cholesterol.

Pacemakers can improve heart function in patients with chemotherapy-induced heart disease
Research has shown that treating chemotherapy-induced cardiomyopathy with commercially available cardiac resynchronization therapy (CRT) delivered through a surgically implanted defibrillator or pacemaker can significantly improve patient outcomes.

Arsenic in drinking water may change heart structure raising risk of heart disease
Drinking water that is contaminated with arsenic may lead to thickening of the heart's main pumping chamber in young adults, according to a new study by researchers at Columbia University Mailman School of Public Health.

New health calculator can help predict heart disease risk, estimate heart age
A new online health calculator can help people determine their risk of heart disease, as well as their heart age, accounting for sociodemographic factors such as ethnicity, sense of belonging and education, as well as health status and lifestyle behaviors.

Wide variation in rate of death between VA hospitals for patients with heart disease, heart failure
Death rates for veterans with ischemic heart disease and chronic heart failure varied widely across the Veterans Affairs (VA) health care system from 2010 to 2014, which could suggest differences in the quality of cardiovascular health care provided by VA medical centers.

Heart failure: The Alzheimer's disease of the heart?
Similar to how protein clumps build up in the brain in people with some neurodegenerative diseases such as Alzheimer's and Parkinson's diseases, protein clumps appear to accumulate in the diseased hearts of mice and people with heart failure, according to a team led by Johns Hopkins University researchers.

Read More: Heart Disease News and Heart Disease Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.