Experimental testosterone patch shows promise for treating diminished sexual function in surgically menopausal women

June 15, 1999

Experimental Testosterone Patch Shows Promise for Treating Diminished Sexual Function in Surgically Menopausal Women
EMBARGOED FOR RELEASE: 15 JUNE 1999 AT 14:00:00 ET US

Contact: Sandra Van
sandy@vancommunications.com
1-800-396-1002
Cedars-Sinai Medical Center

Experimental testosterone patch shows promise for treating diminished sexual function in surgically menopausal women

According to a soon-to-be-released study, an experimental testosterone patch offers new hope for women who suffer from diminished sexual function as a result of surgical menopause (removal of the ovaries and uterus). Glenn Braunstein, M.D., Chair of the Department of Medicine at Cedars Sinai Medical Center, will present the findings at the Endocrine Society Meeting in San Diego on Tuesday, June 15.

The study, which was conducted at nine U.S. Centers and involved 75 surgically menopausal women who suffered from diminished sexual function, found that the women experienced improvements in their sexual function and psychological well-being when small amounts of testosterone were administered with an experimental skin patch. The patch, which was used in combination with standard estrogen therapy, was an alcohol-free matrix patch that was applied to the abdomen and changed twice a week.

This is the first-ever study conducted with a testosterone skin patch to treat sexual problems in surgically menopausal women, and these preliminary results indicate that transdermal testosterone is both beneficial and well tolerated in these women. Further, the study suggests that the small amounts of testosterone normally produced by a woman's ovaries are important for maintaining sexual function and that loss of ovarian testosterone production can markedly diminish the quality of life for some women.

During the study, each woman was treated for 12 weeks with two different doses of testosterone as well as with a placebo treatment, using combinations of active and inactive (placebo) patches. Estrogen replacement therapy was continued throughout the study. The women completed a questionnaire to assess their sexual function at the beginning of the study and at the end of the treatment period. They also completed a questionnaire that assessed their psychological well-being.

The safety of the treatment was monitored for changes in laboratory values, facial and body hair growth, and acne. Hormone levels were measured periodically, and the skin was assessed to determine the local tolerability of the patches.

Overall, the study showed that testosterone levels increased with the normal range in a dose-dependent manner and that estrogen levels did not change. There were improvements in sexual function and psychological well-being which were statistically significant for the higher dose of testosterone when compared to placebo. There was very little skin irritation observed, and there were only minimal effects on facial hair growth and acne. No adverse effects on the levels of cholesterol, glucose, insulin or on the frequence of hot flushes were observed.
-end-
The research was funded by TheraTech, Inc., Salt Lake City and by Procter & Gamble Pharmaceuticals, Cincinnati, Ohio.

THIS INFORMATION IS EMBARGOED UNTIL JUNE 15, 1999 AT 11 A.M. PDT.
To arrange an interview with Dr. Braunstein, please call Sandy Van (Cedars-Sinai Medical Center) at 1-800-396-1002 or e-mail sandy@vancommunications.com.


Cedars-Sinai Medical Center

Related Testosterone Articles from Brightsurf:

ACP issues guideline for testosterone treatment in adult men with age-related low testosterone
Physicians should prescribe testosterone for men with age-related low testosterone only to treat sexual dysfunction, the American College of Physicians (ACP) says in a new evidence-based clinical practice guideline.

Women with asthma appear more likely to have lower levels of testosterone
Women with asthma appear more likely to have lower levels of 'free' (not attached to proteins) testosterone than women who do not have asthma, according to new research published online in the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine.

Penis development needs more than just testes and testosterone
Proper development of the fetal penis requires not just testosterone from the testes, but a second hormone produced by other tissues, including the placenta, according to a new study publishing Feb.

Testosterone treatment over 10 years can improve or reverse type 2 diabetes in men with low testosterone, and induce significant weight loss
New research presented at this year's annual meeting of the European Association for the Study of Diabetes (EASD) reveals that in men with low testosterone who have type 2 diabetes (T2D), testosterone therapy can improve their disease and reverse its progress, and can also induce significant weight loss.

Testosterone replacement therapy may slow the progression of COPD
GALVESTON, Texas -- Researchers from The University of Texas Medical Branch at Galveston found that testosterone replacement therapy may slow disease progression of chronic obstructive pulmonary disease.

Testosterone research brings new hope for cancer patients
Approximately 20 percent of cancer related deaths are attributed to the syndrome of cachexia.

Testosterone prescriptions have sharply dropped in the past few years
Testosterone use in the United States tripled between 2001 and 2011, mostly in men without a clear indication for it.

Use of prescribed testosterone therapy in US decreases in recent years
Testosterone use in the United States tripled from 2001 through 2011, mostly in men without a clear indication.

Testosterone causes men to desire luxury goods
Researchers examine testosterone's effect on men's desire for goods that are considered to have social cachet.

Men's testosterone levels largely determined by where they grow up
Men's testosterone levels are largely determined by their environment during childhood, according to new research.

Read More: Testosterone News and Testosterone Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.