Nav: Home

Certain factors affect vitamin D levels in children with chronic kidney disease

June 16, 2016

Highlights
  • Two-thirds of the children with kidney disease were classified as vitamin D deficient.
  • Children with kidney disease who took vitamin D supplements had vitamin D levels that were 2 times higher than those who did not take supplements.
  • Certain genetic variants were also associated with vitamin D levels.


Vitamin D deficiency often elicits no symptoms, but it may increase the risk of osteoporosis, cancer, cardiovascular disease, and autoimmune disorders.

Washington, DC (June 16, 2016) -- Researchers have identified certain modifiable and non-modifiable factors associated with vitamin D deficiency in children with chronic kidney disease (CKD). The findings, which appear in an upcoming issue of the Clinical Journal of the American Society of Nephrology (CJASN), could help physicians protect the health of these young patients.

Vitamin D deficiency is common in children with chronic kidney disease (CKD). In an attempt to understand why, a team led by Anke Doyon, MD and Franz Schaefer, MD (University of Heidelberg, Germany) looked at how various factors relate to vitamin D levels in 500 children with CKD who were residing in 12 European countries.

Among the major findings:
  • Two-thirds of the patients were classified as vitamin D deficient.
  • Patients who took vitamin D supplements had vitamin D levels that were 2 times higher than those who did not take supplements, and they had a lower prevalence of vitamin D deficiency.
  • Vitamin D levels were lower for certain kidney abnormalities, such as glomerulopathies
  • Vitamin D levels were lower in winter months than at other times of the year.
  • Certain genetic variants were also associated with vitamin D levels, but to a lesser extent than disease-associated factors and vitamin D supplementation.


"Vitamin D levels are influenced more strongly by seasonal factors, the type of disease and nutritional supplementation than by common variants in vitamin D regulating genes," said Dr. Doyon. "Supplementation practices should be reconsidered and intervention studies are needed to define guidelines how to monitor and treat vitamin D deficiency in children with chronic kidney disease."
-end-
Study co-authors include, Bettina Schmiedchen, Anja Sander, Aysun Bayazit MD, Ali Duzova MD, Nur Canpolat MD, Daniela Thurn MD, Karolis Azukaitis MD, Ali Anarat MD, Justine Bacchetta MD, Sevgi Mir MD, Rukshana Shroff MD, Ebru Yilmaz MD, Cengiz Candan MD, Markus Kemper MD, Michel Fischbach MD, Gerard Cortina MD, Günter Klaus MD, Matthias Wuttke MD, Anna Köttgen MD, Anette Melk MD, Uwe Querfeld MD, Franz Schaefer MD.

Disclosures: The authors reported no financial disclosures.

The article, entitled "Genetic, Environmental and Disease-Associated Correlates of Vitamin D Status in Children with CKD," will appear online at http://cjasn.asnjournals.org/ on June 16, 2016, doi: 10.2215/CJN.10210915.

The content of this article does not reflect the views or opinions of The American Society of Nephrology (ASN). Responsibility for the information and views expressed therein lies entirely with the author(s). ASN does not offer medical advice. All content in ASN publications is for informational purposes only, and is not intended to cover all possible uses, directions, precautions, drug interactions, or adverse effects. This content should not be used during a medical emergency or for the diagnosis or treatment of any medical condition. Please consult your doctor or other qualified health care provider if you have any questions about a medical condition, or before taking any drug, changing your diet or commencing or discontinuing any course of treatment. Do not ignore or delay obtaining professional medical advice because of information accessed through ASN. Call 911 or your doctor for all medical emergencies.

Founded in 1966, and with nearly 16,000 members, the American Society of Nephrology (ASN) leads the fight against kidney disease by educating health professionals, sharing new knowledge, advancing research, and advocating the highest quality care for patients.

American Society of Nephrology

Related Kidney Disease Articles:

Combating chronic kidney disease with exercise
A University of Delaware research team is combating chronic kidney disease (CKD) with exercise.
A new mutation in kidney disease
Osaka University researchers find an unexpected mutation in proteins of the exosome could be a valuable biomarker for diagnosing the risk of kidney disease.
New answers for kids with inherited kidney disease
A new gene behind a rare form of inherited childhood kidney disease has been identified by a global research team.
Revealed: The biochemical pathways of kidney disease
In a study, recently published in PLOS Genetics, Chiara Gamberi and her coauthors developed an innovative fruit fly-based model of the types of harmful cysts that can form on kidneys.
Forging new defenses against diabetic kidney disease
Scientists at Joslin Diabetes Center have revealed an unexpected route to slow the progression of diabetic kidney disease, targeting a biological pathway that is the main channel for the metabolism of glucose in the cell.
Kidney disease is a major cause of cardiovascular deaths
In 2013, reduced kidney function was associated with 4 percent of deaths worldwide, or 2.2 million deaths.
A kidney disease's genetic clues are uncovered
Researchers at Columbia University Medical Center have identified genes that are linked to the underlying molecular defect in people with IgA nephropathy, an autoimmune kidney disease.
Beating kidney disease together
Chronic kidney disease is a frequently encountered disorder: more than 10% of the population suffer from such problems.
Reflux and ulcer medications linked to kidney stones and chronic kidney disease
Individuals who took proton pump inhibitors or histamine receptor-2 blockers for heartburn, acid reflux, or ulcers had elevated risks of developing kidney stones.
Method to create kidney organoids from patient cells provides insights on kidney disease
Scientists have developed a method to coax human pluripotent stem cells to mature into cells that go on to form the functional units of the kidney.

Related Kidney Disease Reading:

Best Science Podcasts 2019

We have hand picked the best science podcasts for 2019. Sit back and enjoy new science podcasts updated daily from your favorite science news services and scientists.
Now Playing: TED Radio Hour

Digital Manipulation
Technology has reshaped our lives in amazing ways. But at what cost? This hour, TED speakers reveal how what we see, read, believe — even how we vote — can be manipulated by the technology we use. Guests include journalist Carole Cadwalladr, consumer advocate Finn Myrstad, writer and marketing professor Scott Galloway, behavioral designer Nir Eyal, and computer graphics researcher Doug Roble.
Now Playing: Science for the People

#530 Why Aren't We Dead Yet?
We only notice our immune systems when they aren't working properly, or when they're under attack. How does our immune system understand what bits of us are us, and what bits are invading germs and viruses? How different are human immune systems from the immune systems of other creatures? And is the immune system so often the target of sketchy medical advice? Those questions and more, this week in our conversation with author Idan Ben-Barak about his book "Why Aren't We Dead Yet?: The Survivor’s Guide to the Immune System".