Wearable patch may provide new treatment option for skin cancer

June 16, 2020

WEST LAFAYETTE, Ind. - Conventional melanoma therapies, including chemotherapy and radiotherapy, suffer from the toxicity and side effects of repeated treatments due to the aggressive and recurrent nature of melanoma cells.

Less invasive topical chemotherapies have emerged as alternatives, but their widespread uses have been hindered by both the painful size of the microneedles and the rapidly dissolving behavior of polymers used in the treatments.

Now, Purdue University innovators have created a novel wearable patch to help address the issues and provide an improved treatment experience for people with melanoma. The technology is published in the journal ACS Nano.

"We developed a novel wearable patch with fully miniaturized needles, enabling unobtrusive drug delivery through the skin for the management of skin cancers," said Chi Hwan Lee, a Purdue assistant professor of biomedical engineering and mechanical engineering. "Uniquely, this patch is fully dissolvable by body fluids in a programmable manner such that the patch substrate is dissolved within one minute after the introduction of needles into the skin, followed by gradual dissolution of the silicon needles inside the tissues within several months."

Lee said this gradual slow dissolution of the silicon nanoneedles allows for long-lasting and sustainable delivery of cancer therapeutics.

"The uniqueness of our technology arises from the fact that we used extremely small but long-lasting silicon nanoneedles with sharpened angular tips that are easy for their penetration into the skin in a painless and minimally invasive manner," Lee said.

The Purdue innovators developed a novel design of bioresorbable silicon nanoneedles that are built on a thin, flexible and water-soluble medical film. The water-soluble film serves as a temporary holder that can be conformably interfaced with the soft, curvilinear surface of the skin during the insertion of the nanoneedles, followed by rapid, complete dissolution within a minute.

The surface of the nanoneedles is configured with nanoscale pores and provides a large drug loading capacity comparable to those using conventional microneedles.

Lee said the nanoneedles could deliver the chemotherapeutic drugs to target melanoma sites in a sustainable manner. The silicon nanoneedles are biocompatible and dissolvable in tissue fluids, such that they can be completely resorbed in the body over months in a harmless manner.

This work is supported by the Air Force Office of Scientific Research (AFOSR: FA2386-18-1-40171).

Lee said he started working on this type of technology after seeing his daughter express fearful thoughts about needles when receiving vaccinations.
-end-
The team worked with the Purdue Research Foundation Office of Technology Commercialization to patent this technology. The office recently moved into the Convergence Center for Innovation and Collaboration in Discovery Park District, adjacent to the Purdue campus.

The researchers are looking for partners to continue developing their technology. For more information on licensing and other opportunities, contact Patrick Finnerty of OTC at pwfinnerty@prf.org and mention track code 2020-LEE-68893.

Lee's team worked with Yoon Yeo from Purdue's College of Pharmacy and Dong Rip Kim at Hanyang University in South Korea to develop and test the technology.

About Purdue Research Foundation Office of Technology Commercialization

The Purdue Research Foundation Office of Technology Commercialization operates one of the most comprehensive technology transfer programs among leading research universities in the U.S. Services provided by this office support the economic development initiatives of Purdue University and benefit the university's academic activities through commercializing, licensing and protecting Purdue intellectual property. The office recently moved into the Convergence Center for Innovation and Collaboration in Discovery Park District, adjacent to the Purdue campus. In fiscal year 2019, the office reported 136 deals finalized with 231 technologies signed, 380 disclosures received and 141 issued U.S. patents. The office is managed by the Purdue Research Foundation, which received the 2019 Innovation and Economic Prosperity Universities Award for Place from the Association of Public and Land-grant Universities. In 2020, IPWatchdog Institute ranked Purdue third nationally in startup creation and in the top 20 for patents. The Purdue Research Foundation is a private, nonprofit foundation created to advance the mission of Purdue University. Contact otcip@prf.org for more information.

Writer: Chris Adam, cladam@prf.org

Source: Chi Hwan Lee, lee2270@purdue.edu

Purdue University

Related Melanoma Articles from Brightsurf:

Boosting treatments for metastatic melanoma
University of Cincinnati clinician-scientist Soma Sengupta, MD, PhD, says that new findings from her and Daniel Pomeranz Krummel's, PhD, team might have identified a treatment-boosting drug to enhance effectiveness of therapies for metastatic cancer and make them less toxic, giving patients a fighting chance at survival and improved quality of life.

A promising new tool in the fight against melanoma
An Edith Cowan University (ECU) study has revealed that a key blood marker of cancer could be used to select the most effective treatment for melanoma.

New targets for melanoma treatment
A collaborative study led by Monash University's Biomedicine Discovery Institute and the Olivia Newton-John Cancer Research Institute (ONJCRI) has uncovered new markers (HLA-associated peptides) that are uniquely present on melanoma tumours and could pave the way for therapeutic vaccines to be developed in the fight against melanoma.

Innovative smartphone-camera adaptation images melanoma and non-melanoma
An article published in the Journal of Biomedical Optics (JBO), ''Point-of-care, multispectral, smartphone-based dermascopes for dermal lesion screening and erythema monitoring,'' shows that standard smartphone technology can be adapted to image skin lesions, providing a low-cost, accessible medical diagnostic tool for skin cancer.

Antihistamines may help patients with malignant melanoma
Can a very common allergy medicine improve survival among patients suffering from the serious skin cancer, malignant melanoma?

Blood test for deadly eye melanoma
A simple blood test could soon become the latest monitoring tool for the early detection of melanoma in the eye.

Analysis of melanoma in US by age groups
This study used registry data to determine annual rates of melanoma in pediatric, adolescent, young adult and adult age groups, and the findings suggest an apparent decrease among adolescent and young adults between 2006 and 2015 but increases in older adults.

Vitamin D dials down the aggression in melanoma cells
Vitamin D influences the behaviour of melanoma cells in the lab by making them less aggressive, Cancer Research UK scientists have found.

B cells linked to immunotherapy for melanoma
Immunotherapy uses our body's own immune system to fight cancer.

Five things to know about melanoma
'Five things to know about ... melanoma' in CMAJ (Canadian Medical Association Journal) provides a brief overview of this malignant skin cancer for physicians and patients.

Read More: Melanoma News and Melanoma Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.