Molecular analysis could improve the early detection and prevention of endometrial cancer

June 17, 2019

The use of molecular biomarkers in minimally invasive sampling opens a promising perspective for the early detection of endometrial cancer. This is the conclusion reached by the members of Screenwide research group, formed by researchers from the Bellvitge Biomedical Research Institute (IDIBELL) and the Catalan Institute of Oncology (ICO-Hospitalet). The article that they have prepared, and that has been published in the International Journal of Cancer, highlights the gaps that exist in current knowledge to accelerate the implementation of new technologies, with the aim of improving the screening and the early detection in clinical environments of this type of women cancer.

Due to the anatomical continuity between the uterine cavity and the cervix, the genomic exploitation of the biological material from the Papanicolaou test, or cervical cytology, which is routinely used in cervical cancer prevention programs, represents, together with other methods of non-invasive sampling, a unique opportunity to detect signs of upper genital tract disease. This fact can contribute to improve the diagnosis and prevention of endometrial cancer.

Currently, strategies for detecting the signs of this cancer are limited to high-risk populations and symptomatic women, since 90% of endometrial cancers present with abnormal bleeding. The new analyzes will not only clearly benefit these cases: their potential could have an impact on better screening of asymptomatic women. Molecular tests can help refine current diagnostic algorithms, since they will reduce the failure rate of classical histological diagnosis. In addition, minimally invasive methods are more appropriate in large populations of asymptomatic women, since they are much better tolerated. The first women to benefit from this new screening approach will probably be those with a family history of cancer, as in the case of Lynch syndrome, due to its high underlying risk.

The Screenwide group was created in 2016 with the aim of developing tools for early detection and screening of endometrial and ovarian cancer. The team is led by the epidemiology group (Dr. Laura Costas), with the alliance of pathology groups (Dr. Xavier Matias-Guiu), gynecology (Dr. Jordi Ponce), oncology (Dr. Josep Maria Piulats), Procure (Dr. Álvaro Aytés), and genetic counseling (Dr. Joan Brunet). The group has the international collaboration of the Endometrial Cancer Epidemiology Consortium (Dr. Sara Olson), the John Hopkins University (Dr. Bert Vogelstein) and the Forecee Consortium (Dr. Martin Widschwendter); and, nationally, with the Vall d'Hebron Research Institute (VHIR, Dr. Eva Colás), among others. During the last two years, the combined effort of this multidisciplinary group has allowed the recruitment of almost 500 women and the gathering of more than 1,600 biological samples. All this information will be the basis to be able to evaluate new detection strategies for endometrial and ovarian cancer at an early stage.

IDIBELL-Bellvitge Biomedical Research Institute

Related Cancer Articles from Brightsurf:

New blood cancer treatment works by selectively interfering with cancer cell signalling
University of Alberta scientists have identified the mechanism of action behind a new type of precision cancer drug for blood cancers that is set for human trials, according to research published in Nature Communications.

UCI researchers uncover cancer cell vulnerabilities; may lead to better cancer therapies
A new University of California, Irvine-led study reveals a protein responsible for genetic changes resulting in a variety of cancers, may also be the key to more effective, targeted cancer therapy.

Breast cancer treatment costs highest among young women with metastic cancer
In a fight for their lives, young women, age 18-44, spend double the amount of older women to survive metastatic breast cancer, according to a large statewide study by the University of North Carolina at Chapel Hill.

Cancer mortality continues steady decline, driven by progress against lung cancer
The cancer death rate declined by 29% from 1991 to 2017, including a 2.2% drop from 2016 to 2017, the largest single-year drop in cancer mortality ever reported.

Stress in cervical cancer patients associated with higher risk of cancer-specific mortality
Psychological stress was associated with a higher risk of cancer-specific mortality in women diagnosed with cervical cancer.

Cancer-sniffing dogs 97% accurate in identifying lung cancer, according to study in JAOA
The next step will be to further fractionate the samples based on chemical and physical properties, presenting them back to the dogs until the specific biomarkers for each cancer are identified.

Moffitt Cancer Center researchers identify one way T cell function may fail in cancer
Moffitt Cancer Center researchers have discovered a mechanism by which one type of immune cell, CD8+ T cells, can become dysfunctional, impeding its ability to seek and kill cancer cells.

More cancer survivors, fewer cancer specialists point to challenge in meeting care needs
An aging population, a growing number of cancer survivors, and a projected shortage of cancer care providers will result in a challenge in delivering the care for cancer survivors in the United States if systemic changes are not made.

New cancer vaccine platform a potential tool for efficacious targeted cancer therapy
Researchers at the University of Helsinki have discovered a solution in the form of a cancer vaccine platform for improving the efficacy of oncolytic viruses used in cancer treatment.

American Cancer Society outlines blueprint for cancer control in the 21st century
The American Cancer Society is outlining its vision for cancer control in the decades ahead in a series of articles that forms the basis of a national cancer control plan.

Read More: Cancer News and Cancer Current Events is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to