Nav: Home

Antioxidant agent may prevent chronic kidney disease and Parkinson's disease

June 18, 2020

Osaka, Japan - Oxidative stress is the result of reactive oxygen species (ROS) generation, and can be damaging to cells and tissues. In a new study, researchers from Osaka University developed a novel dietary silicon (Si)-based antioxidant agent that suppressed the development and progression of kidney failure and Parkinson's disease in rodents.

ROS are generated as a result of metabolism and the immune response, but also during certain disease processes, contributing to continued tissue damage. Chronic kidney disease and Parkinson's disease are among those diseases that have been shown to result from oxidative stress. Although ROS encompass several different molecules, not all ROS are alike. While Hydroxyl (OH) radicals are highly damaging to tissues through their effect on cells and DNA, others, like hydrogen peroxide and superoxide anions, are important components of the normal immune response.

"Eliminating only hydroxyl radicals is important to avoid disrupting normal physiological processes," says lead author of the study Yuki Kobayashi. "Previous attempts to do so, like taking in hydrogen-rich water or breathing in hydrogen-containing air, have shown limited results. We wanted to develop a new dietary agent that efficiently enables the elimination of damaging hydroxyl radicals."

To achieve their goal, the researchers produced a novel Si-based agent from Si powder. Because the agent is taken by mouth, the researchers first evaluated the efficacy of the agent in an environment similar to that in bowels, that is, a pH of 8.3 and at 36°C. 1g of the new agent was able to generate 400 ml of hydrogen in 24 hours, which is the equivalent of drinking 22 liters of hydrogen-rich water. The new agent thus enabled the continuous production of high amounts of an OH-eliminating molecule.

But was it sufficient to protect tissues from being damaged by ROS? To address this question, the researchers turned to animal models of chronic kidney disease and Parkinson's disease. When they fed rats who had 5/6 of their kidneys removed with the Si-based agent, kidney function was preserved and tissue levels of oxidative stress as well as inflammation were significantly lowered, as compared with those of control animals. Similarly, when they fed animals with Parkinson's disease with the Si-based agent, degeneration of neurons responsible for the disease was significantly attenuated.

"These are striking results that show that our Si-based agent is effective in preventing the progression of chronic kidney disease and Parkinson's disease in well-established animal models," says corresponding author Shoichi Shimada. "Our findings could provide new insights into the clinical management of patients with these diseases, for which currently no curative approach exists."
-end-
The article, "Renoprotective and neuroprotective effects of enteric hydrogen generation from Si-based agent," was published in Scientific Reports at DOI: https://doi.org/10.1038/s41598-020-62755-9

About Osaka University

Osaka University was founded in 1931 as one of the seven imperial universities of Japan and now has expanded to one of Japan's leading comprehensive universities. The University has now embarked on open research revolution from a position as Japan's most innovative university and among the most innovative institutions in the world according to Reuters 2015 Top 100 Innovative Universities and the Nature Index Innovation 2017. The university's ability to innovate from the stage of fundamental research through the creation of useful technology with economic impact stems from its broad disciplinary spectrum.

Website: https://resou.osaka-u.ac.jp/en/top

Osaka University

Related Hydrogen Articles:

Hydrogen vehicles might soon become the global norm
Roughly one billion cars and trucks zoom about the world's roadways.
Hydrogen economy with mass production of high-purity hydrogen from ammonia
The Korea Institute of Science and Technology (KIST) has made an announcement about the technology to extract high-purity hydrogen from ammonia and generate electric power in conjunction with a fuel cell developed by a team led by Young Suk Jo and Chang Won Yoon from the Center for Hydrogen and Fuel Cell Research.
Superconductivity: It's hydrogen's fault
Last summer, it was discovered that there are promising superconductors in a special class of materials, the so-called nickelates.
Hydrogen energy at the root of life
A team of international researchers in Germany, France and Japan is making progress on answering the question of the origin of life.
Hydrogen alarm for remote hydrogen leak detection
Tomsk Polytechnic University jointly with the University of Chemistry and Technology of Prague proposed new sensors based on widely available optical fiber to ensure accurate detection of hydrogen molecules in the air.
Preparing for the hydrogen economy
In a world first, University of Sydney researchers have found evidence of how hydrogen causes embrittlement of steels.
Hydrogen boride nanosheets: A promising material for hydrogen carrier
Researchers at Tokyo Institute of Technology, University of Tsukuba, and colleagues in Japan report a promising hydrogen carrier in the form of hydrogen boride nanosheets.
World's fastest hydrogen sensor could pave the way for clean hydrogen energy
Hydrogen is a clean and renewable energy carrier that can power vehicles, with water as the only emission.
Chemical hydrogen storage system
Hydrogen is a highly attractive, but also highly explosive energy carrier, which requires safe, lightweight and cheap storage as well as transportation systems.
Observing hydrogen's effects in metal
Microscopy technique could help researchers design safer reactor vessels or hydrogen storage tanks.
More Hydrogen News and Hydrogen Current Events

Trending Science News

Current Coronavirus (COVID-19) News

Top Science Podcasts

We have hand picked the top science podcasts of 2020.
Now Playing: TED Radio Hour

Listen Again: The Power Of Spaces
How do spaces shape the human experience? In what ways do our rooms, homes, and buildings give us meaning and purpose? This hour, TED speakers explore the power of the spaces we make and inhabit. Guests include architect Michael Murphy, musician David Byrne, artist Es Devlin, and architect Siamak Hariri.
Now Playing: Science for the People

#576 Science Communication in Creative Places
When you think of science communication, you might think of TED talks or museum talks or video talks, or... people giving lectures. It's a lot of people talking. But there's more to sci comm than that. This week host Bethany Brookshire talks to three people who have looked at science communication in places you might not expect it. We'll speak with Mauna Dasari, a graduate student at Notre Dame, about making mammals into a March Madness match. We'll talk with Sarah Garner, director of the Pathologists Assistant Program at Tulane University School of Medicine, who takes pathology instruction out of...
Now Playing: Radiolab

What If?
There's plenty of speculation about what Donald Trump might do in the wake of the election. Would he dispute the results if he loses? Would he simply refuse to leave office, or even try to use the military to maintain control? Last summer, Rosa Brooks got together a team of experts and political operatives from both sides of the aisle to ask a slightly different question. Rather than arguing about whether he'd do those things, they dug into what exactly would happen if he did. Part war game part choose your own adventure, Rosa's Transition Integrity Project doesn't give us any predictions, and it isn't a referendum on Trump. Instead, it's a deeply illuminating stress test on our laws, our institutions, and on the commitment to democracy written into the constitution. This episode was reported by Bethel Habte, with help from Tracie Hunte, and produced by Bethel Habte. Jeremy Bloom provided original music. Support Radiolab by becoming a member today at Radiolab.org/donate.     You can read The Transition Integrity Project's report here.