Nav: Home

Exercise makes the blood of obese people healthier

June 19, 2018

Exercise can reduce inflammation in obese people by changing the characteristics of their blood, according to new research published in The Journal of Physiology.

Obesity is a global health challenge, with approximately one-third of adults affected. Obesity increases the risk of health problems, such as heart disease and type 2 diabetes. Many of the health problems linked to obesity are a result of chronic inflammation. Inflammation is a natural process in the body in response to harm, but in obese people it can become long term and this can lead to damage of healthy tissue. Certain blood cells are more likely to cause inflammation, and if these cells are made in the body in greater numbers than normal they can spread to organs in the body and cause them to malfunction.

The blood cells responsible for causing inflammation are formed from stem cells within the body. This new research is the first to show that exercise alters the characteristics of these blood forming stem cells and therefore reduces the number of blood cells likely to cause inflammation. These findings provide a new explanation of how exercise may improve health in adults with obesity.

Young, lean adults and young, obese adults (who were otherwise healthy) were recruited for this study. Comprehensive physiological characterisation of all participants occurred before and after completion of a six-week exercise program. The exercise program consisted of three bicycling or treadmill running sessions per week with each session lasting approximately one hour. Blood was collected before and after the exercise training intervention to quantify blood-forming stem cells. The results of the study demonstrated that exercise reduced the number of blood-forming stem cells associated with the production of the type of blood cells responsible for inflammation.

The research group is now interested in determining if these changes in blood cell populations improve the function of muscle and fat involved in energy consumption and storage among people with obesity. They are also looking to investigate whether these effects of exercise on blood cells are also seen in other chronic conditions associated with increased inflammation.

Principal Investigator, Dr Michael De Lisio was delighted by the impact the exercise intervention had on some of the participants' exercise habits:

"This research is important because it helps us understand how and why exercise improves the health of people with obesity."

"After participating in the exercise intervention, some participants were inspired to participate in our local half-marathon. This enthusiasm for exercise and building the habit of increased physical activity is one of the most rewarding aspects of conducting these types of human exercise trials".
-end-


The Physiological Society

Related Stem Cells Articles:

A protein that stem cells require could be a target in killing breast cancer cells
Researchers have identified a protein that must be present in order for mammary stem cells to perform their normal functions.
Approaching a decades-old goal: Making blood stem cells from patients' own cells
Researchers at Boston Children's Hospital have, for the first time, generated blood-forming stem cells in the lab using pluripotent stem cells, which can make virtually every cell type in the body.
New research finds novel method for generating airway cells from stem cells
Researchers have developed a new approach for growing and studying cells they hope one day will lead to curing lung diseases such as cystic fibrosis through 'personalized medicine.'
Mature heart muscle cells created in the laboratory from stem cells
Generating mature and viable heart muscle cells from human or other animal stem cells has proven difficult for biologists.
Mutations in bone cells can drive leukemia in neighboring stem cells
DNA mutations in bone cells that support blood development can drive leukemia formation in nearby blood stem cells.
Scientists take aging cardiac stem cells out of semiretirement to improve stem cell therapy
With age, the chromosomes of our cardiac stem cells compress as they move into a state of safe, semiretirement.
Purest yet liver-like cells generated from induced pluripotent stem cells
A team of researchers from the Medical University of South Carolina and elsewhere has found a better way to purify liver cells made from induced pluripotent stem cells.
Stem cell scientists discover genetic switch to increase supply of stem cells from cord blood
International stem cell scientists, co-led in Canada by Dr. John Dick and in the Netherlands by Dr.
Stem cells from diabetic patients coaxed to become insulin-secreting cells
Signaling a potential new approach to treating diabetes, researchers at Washington University School of Medicine in St.

Related Stem Cells Reading:

Best Science Podcasts 2019

We have hand picked the best science podcasts for 2019. Sit back and enjoy new science podcasts updated daily from your favorite science news services and scientists.
Now Playing: TED Radio Hour

Bias And Perception
How does bias distort our thinking, our listening, our beliefs... and even our search results? How can we fight it? This hour, TED speakers explore ideas about the unconscious biases that shape us. Guests include writer and broadcaster Yassmin Abdel-Magied, climatologist J. Marshall Shepherd, journalist Andreas Ekström, and experimental psychologist Tony Salvador.
Now Playing: Science for the People

#514 Arctic Energy (Rebroadcast)
This week we're looking at how alternative energy works in the arctic. We speak to Louie Azzolini and Linda Todd from the Arctic Energy Alliance, a non-profit helping communities reduce their energy usage and transition to more affordable and sustainable forms of energy. And the lessons they're learning along the way can help those of us further south.