'Goldilocks' neurons promote REM sleep

June 19, 2019

Every night while sleeping, we cycle between two very different states of sleep. Upon falling asleep, we enter non-rapid eye movement (non-REM) sleep where our breathing is slow and regular and movement of our limbs or eyes are minimal. Approximately 90 minutes later, how-ever, we enter rapid eye movement (REM) sleep. This is a paradoxical state where our breath-ing becomes fast and irregular, our limbs twitch, and our eyes move rapidly. In REM sleep, our brain is highly active, but we also become paralyzed and we lose the ability to thermoregulate or maintain our constant body temperature. "This loss of thermoregulation in REM sleep is one of the most peculiar aspects of sleep, particularly since we have finely-tuned mechanisms that control our body temperature while awake or in non-REM sleep", says Markus Schmidt of the Department for BioMedical Research (DBMR) of the University of Bern, and the Department of Neurology, Inselspital, Bern University Hospital. On the one hand, the findings confirm a hy-pothesis proposed earlier by Schmidt, senior author of the study, and on the other hand repre-sent a breakthrough for sleep medicine. The paper was published in "Current Biology" and highlighted by the editors with a comment.

A control mechanism saving energy

The need to maintain a constant body temperature is our most expensive biological function. Panting, piloerection, sweating, or shivering are all energy consuming body reactions. In his hypothesis, Markus Schmidt suggested that REM sleep is a behavioral strategy that shifts en-ergy resources away from costly thermoregulatory defense toward, instead, the brain to en-hance many brain functions. According to this energy allocation hypothesis of sleep, mammals have evolved mechanisms to increase REM sleep when the need for defending our body tem-perature is minimized or, rather, to sacrifice REM sleep when we are cold. "My hypothesis pre-dicts that we should have neural mechanisms to dynamically modulate REM sleep expression as a function of our room temperature", says Schmidt. Neuroscientists at the DBMR at the Uni-versity of Bern and the Department of Neurology at Inselspital, Bern University Hospital, now confirmed his hypothesis and found neurons in the hypothalamus that specifically increase REM sleep when the room temperature is "just right".

REM sleep promoting neurons

The researchers discovered that a small population of neurons within the hypothalamus, called melanin-concentrating hormone (MCH) neurons, play a critical role in how we modulate REM sleep expression as a function of ambient (or room) temperature. The researchers showed that mice will dynamically increase REM sleep when the room temperature is warmed to the high end of their comfort zone, similar to what has been shown for human sleep. However, genet-ically engineered mice lacking the receptor for MCH are no longer able to increase REM sleep during warming, as if they are blind to the warming temperature. The authors used optogenet-ics technics to specifically turn on or off MCH neurons using a laser light time locked to the temperature warming periods. Their work confirms the necessity of the MCH system to increase REM sleep when the need for body temperature control is minimized.

Breakthrough for sleep medicine

This is the first time that an area of the brain has been found to control REM sleep as a func-tion of room temperature. "Our discovery of these neurons has major implications for the con-trol of REM sleep", says Schmidt. "It shows that the amount and timing of REM sleep are finely tuned with our immediate environment when we do not need to thermoregulate. It also con-firms how dream sleep and the loss of thermoregulation are tightly integrated".

REM sleep is known to play an important role in many brain functions such as memory consoli-dation. REM sleep comprises approximately one quarter of our total sleep time. "These new data suggest that the function of REM sleep is to activate important brain functions specifically at times when we do not need to expend energy on thermoregulation, thus optimizing use of energy resources", says Schmidt.
-end-


University of Bern

Related Neurons Articles from Brightsurf:

Paying attention to the neurons behind our alertness
The neurons of layer 6 - the deepest layer of the cortex - were examined by researchers from the Okinawa Institute of Science and Technology Graduate University to uncover how they react to sensory stimulation in different behavioral states.

Trying to listen to the signal from neurons
Toyohashi University of Technology has developed a coaxial cable-inspired needle-electrode.

A mechanical way to stimulate neurons
Magnetic nanodiscs can be activated by an external magnetic field, providing a research tool for studying neural responses.

Extraordinary regeneration of neurons in zebrafish
Biologists from the University of Bayreuth have discovered a uniquely rapid form of regeneration in injured neurons and their function in the central nervous system of zebrafish.

Dopamine neurons mull over your options
Researchers at the University of Tsukuba have found that dopamine neurons in the brain can represent the decision-making process when making economic choices.

Neurons thrive even when malnourished
When animal, insect or human embryos grow in a malnourished environment, their developing nervous systems get first pick of any available nutrients so that new neurons can be made.

The first 3D map of the heart's neurons
An interdisciplinary research team establishes a new technological pipeline to build a 3D map of the neurons in the heart, revealing foundational insight into their role in heart attacks and other cardiac conditions.

Mapping the neurons of the rat heart in 3D
A team of researchers has developed a virtual 3D heart, digitally showcasing the heart's unique network of neurons for the first time.

How to put neurons into cages
Football-shaped microscale cages have been created using special laser technologies.

A molecule that directs neurons
A research team coordinated by the University of Trento studied a mass of brain cells, the habenula, linked to disorders like autism, schizophrenia and depression.

Read More: Neurons News and Neurons Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.