Communication between nervous & immune systems detailed in New Feinstein Institute

June 20, 2017

MANHASSET, NY -- Sangeeta S. Chavan, PhD, Valentin A. Pavlov, PhD, and Kevin J. Tracey, MD, president and CEO of The Feinstein Institute for Medical Research at Northwell Health, have completed a detailed analysis of how the nervous and immune systems communicate with each other, which will help to develop novel medications and bioelectronic medicine devices to treat disease and injury. The analysis is published today in Immunity.

The paper is the result of long-standing collaborations between Dr. Chavan and Dr. Pavlov, each Feinstein associate professors, along with Dr. Tracey. The researchers examined various studies that outline the different biological mechanisms of neuro-immune communication. These findings clearly demonstrate that the nervous system regulates immune responses to control inflammation, the Feinstein Institute team claims.

"Neuro-immune communication is an exciting area of research that bridges different disciplines and addresses questions of great importance," said Dr. Chavan, the lead author of the paper. "Better understanding of the mechanisms by which the nervous system regulates inflammation and immunity may revolutionize how we approach treatment of autoimmune and other conditions."

This new knowledge of how the nervous system regulates the immune system has already paved the way to clinical trials of implantable bioelectronic devices to treat diseases that were historically treated with drugs or biological agents, Feinstein Institute researchers found. "Though more research is required, the positive results of these trials are very encouraging to researchers and medical professionals," said Dr. Pavlov, co-author on the paper.

"We are continuing to crack the code of how the nervous system and immune system interact," said Dr. Tracey, co-author on the paper. "This will help us to develop more targeted therapies, which harness the nervous system to therapeutic advantage."
-end-
About the Feinstein Institute

The Feinstein Institute for Medical Research is the research arm of Northwell Health, the largest healthcare provider in New York. Home to 50 research laboratories and to clinical research throughout dozens of hospitals and outpatient facilities, the Feinstein includes 4,000 researchers and staff who are making breakthroughs in molecular medicine, genetics, oncology, brain research, mental health, autoimmunity, and bioelectronic medicine - a new field of science that has the potential to revolutionize medicine. For more information about how we empower imagination and pioneer discovery, visit FeinsteinInstitute.org

Northwell Health

Related Immune System Articles from Brightsurf:

How the immune system remembers viruses
For a person to acquire immunity to a disease, T cells must develop into memory cells after contact with the pathogen.

How does the immune system develop in the first days of life?
Researchers highlight the anti-inflammatory response taking place after birth and designed to shield the newborn from infection.

Memory training for the immune system
The immune system will memorize the pathogen after an infection and can therefore react promptly after reinfection with the same pathogen.

Immune system may have another job -- combatting depression
An inflammatory autoimmune response within the central nervous system similar to one linked to neurodegenerative diseases such as multiple sclerosis (MS) has also been found in the spinal fluid of healthy people, according to a new Yale-led study comparing immune system cells in the spinal fluid of MS patients and healthy subjects.

COVID-19: Immune system derails
Contrary to what has been generally assumed so far, a severe course of COVID-19 does not solely result in a strong immune reaction - rather, the immune response is caught in a continuous loop of activation and inhibition.

Immune cell steroids help tumours suppress the immune system, offering new drug targets
Tumours found to evade the immune system by telling immune cells to produce immunosuppressive steroids.

Immune system -- Knocked off balance
Instead of protecting us, the immune system can sometimes go awry, as in the case of autoimmune diseases and allergies.

Too much salt weakens the immune system
A high-salt diet is not only bad for one's blood pressure, but also for the immune system.

Parkinson's and the immune system
Mutations in the Parkin gene are a common cause of hereditary forms of Parkinson's disease.

How an immune system regulator shifts the balance of immune cells
Researchers have provided new insight on the role of cyclic AMP (cAMP) in regulating the immune response.

Read More: Immune System News and Immune System Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.