Lemurs lose weight with 'life-extending' supplement

June 21, 2010

The anti-obesity properties of resveratrol have been demonstrated for the first time in a primate. Researchers writing in the open access journal BMC Physiology studied the compound, generated naturally by plants to ward off pathogens, which has received much interest as a dietary supplement for its supposed life-extending effects.

Fabienne Aujard, from the Centre National de la Recherche Scientifique, Paris, France, worked with a team of researchers to investigate the effect of dietary supplementation with resveratrol on the weight, metabolism and energy intake of six mouse lemurs. She said, "The physiological benefits of resveratrol are currently under intensive investigation, with recent work suggesting that it could be a good candidate for the development of obesity therapies. We've found that lemurs eating a diet supplemented with the compound decreased their energy intake by 13% and increased their resting metabolic rate by 29%".

The researchers demonstrated that a four-week resveratrol supplementation was associated with a decrease in food intake and a reduction in seasonal body-mass gain. The response to resveratrol supplementation also involved significant changes in the animals' body temperatures. According to Dr Aujard, "These results provide novel information on the potential effects of resveratrol on energy metabolism and control of body mass in a primate".
-end-
Notes to Editors

1. Resveratrol suppresses body mass gain in a seasonal non-human primate model of obesity
Alexandre Dal-Pan, Stephane Blanc and Fabienne Aujard
BMC Physiology (in press)

During embargo, article available here: http://www.biomedcentral.com/imedia/2182279043377416_article.pdf?random=616819

After the embargo, article available at the journal website: http://www.biomedcentral.com/bmcphysiol/

Please name the journal in any story you write. If you are writing for the web, please link to the article. All articles are available free of charge, according to BioMed Central's open access policy.

Article citation and URL available on request at press@biomedcentral.com on the day of publication.

2. BMC Physiology is an open access journal publishing original peer-reviewed research articles in cellular, tissue-level, organismal, functional, and developmental aspects of physiological processes. BMC Physiology (ISSN 1472-6793) is indexed/tracked/covered by PubMed, MEDLINE, BIOSIS, CAS, EMBASE, Scopus, Zoological Record, CABI and Google Scholar.

3. BioMed Central (http://www.biomedcentral.com/) is an STM (Science, Technology and Medicine) publisher which has pioneered the open access publishing model. All peer-reviewed research articles published by BioMed Central are made immediately and freely accessible online, and are licensed to allow redistribution and reuse. BioMed Central is part of Springer Science+Business Media, a leading global publisher in the STM sector.

BioMed Central

Related Resveratrol Articles from Brightsurf:

Eelgrass acid and resveratrol produced by cell factories for the first time
Scientists are now able to produce a wide range of sulfated aromatic compounds such as antifouling eelgrass acid, resveratrol and vanillic acid derivatives using microbial production hosts.

Compound found in red wine opens door for new treatments for depression, anxiety
A new University at Buffalo-led study has revealed that the plant compound resveratrol, which is found in red wine, displays anti-stress effects by blocking the expression of an enzyme related to the control of stress in the brain.

Red wine's resveratrol could help Mars explorers stay strong, says Harvard study
Mars is about 9 months from Earth with today's tech, NASA reckons.

A grape constituent protects against cancer
Lung cancer is the deadliest form of cancer, and 80 percent of death are related to smoking.

Is resveratrol an effective add-on to NSAIDS to treat knee osteoarthritis?
In what researchers state is the first pilot clinical trial to assess the effects of resveratrol on pain severity and levels of inflammatory biomarkers in patients with mild to moderate knee osteoarthritis, the scientists compared treatment with a nonsteroidal anti-inflammatory drug (NSAID) combined with either resveratrol or placebo over 90 days.

Substance found in grapes prevents agglomeration of a mutant protein that leads to cancer
A novel Brazilian study published in Oncotarget is the first to show the action of resveratrol, a bioactive compound present in grapes and red wine, on the inhibition of aggregates of the mutant p53 protein.

Metabolites of Resveratrol (Longevinex) pass through blood-ocular barriers in humans
On the heels of a study published last year that showed the red wine molecule resveratrol and its metabolites are found in human cerebrospinal fluid and therefore penetrate the blood-brain barrier, for the first time metabolites of the red wine molecule resveratrol have been detected in ocular tissues of humans as well.

University of Alberta research may provide solutions for the future treatment of diabetes
In a study published in the journal Diabetes, researchers at the University of Alberta found that feeding resveratrol to obese mice over a period of 6 weeks altered the makeup of the bacteria in their intestines, improving glucose tolerance.

Resveratrol preserves neuromuscular synapses, muscle fibers in aging mice
red wine, and metformin, a drug often prescribed to fight type 2 diabetes, have many of the neuroprotective benefits of a low-calorie diet and exercise.

Resveratrol may be an effective intervention for lung aging
In a study led by Barbara Driscoll, Ph.D., of The Saban Research Institute of Children's Hospital Los Angeles, researchers demonstrate, for the first time that inhaled resveratrol treatments slow aging-related degenerative changes in mouse lung.

Read More: Resveratrol News and Resveratrol Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.