Nav: Home

Antidiabetic action of natural fatty acid derivatives not confirmed

June 21, 2018

A research consortium between the healthcare company Sanofi and Johannes Gutenberg University Mainz (JGU) investigated the antidiabetic action of certain natural fatty acids, so-called FAHFAs, which US-American scientists had reported in 2014. For some of these compounds, e.g. 5-PAHSA and 9-PAHSA, elevated levels were found in mice which overexpressed the glucose transporter Glut4. This transporter is controlled by insulin and causes the uptake of blood glucose in particular into muscle cells. It had been reported that both PAHSA isomers occur in food and are also produced by human cells. Diabetics have lower blood levels of these compounds than healthy individuals. When mice were fed with a FAHFA-enriched diet, their blood glucose levels were found to decrease and insulin was released.

These results published in a prominent journal caused a stir among scientists as they suggested a new point of attack in the fight against a widespread disease. Chemists under guidance of Professor Till Opatz from Mainz University synthesized the stereoisomers of 5- and 9-PAHSA and sent them to their colleagues at Sanofi in Frankfurt for biological testing. In some of the tests, rudimentary metabolic changes could be detected but the overall effect of the compounds was sobering: none of these molecules was able to achieve positive effects on clearly defined endpoints in metabolism.

The results of the researchers from Frankfurt and Mainz recently appeared in Cell Metabolism, a highly renowned international scientific journal. Now the German scientists hope for a constructive discussion on the discrepancy between both studies resulting in a better understanding of the disease models.

The current publication demonstrates the successful collaboration between a university and a research-active healthcare company in a highly relevant area of basic research in biomedicine. It underlines the importance of verification of scientific results and their disclosure.

E. Pflimlin et al., Acute and repeated treatment with 5- or 9-PAHSA isomers does not improve glucose control in mice
Cell Metabolism, June 21, 2018
DOI: 10.1016/j.cmet.2018.05.028

Further Links: - Discovery of a Class of Endogenous Mammalian Lipids with Anti-Diabetic and Anti-inflammatory Effects, Cell, 09 October 2014

Johannes Gutenberg Universitaet Mainz

Related Blood Glucose Articles:

Research elucidates hormone ghrelin's role in blood glucose regulation
UT Southwestern research investigating the blood glucose-regulatory actions of the hormone ghrelin may have implications for development of new treatments for diabetes.
Bio-sensing contact lens could someday measure blood glucose, other bodily functions
Transparent biosensors embedded into contact lenses could soon allow doctors and patients to monitor blood glucose levels and a host of other telltale signs of disease without invasive tests.
Convenient and easy to use glucose monitoring and maintenance
A research group from the Center for Nanoparticle Research within the Institute for Basic Science has developed a convenient and accurate sweat-based glucose monitoring and maintenance device.
How rare sugars might help control blood glucose
In an era when the label 'natural' hits a sweet spot with consumers, some uncommon sugars emerging on the market could live up to the connotation.
Continuous glucose monitoring lowers blood sugar in the long term for type 1 diabetes
Significantly decreased blood sugar levels over time -- and increased well-being.
Low blood glucose levels in hospitalized patients linked to increased mortality risk
In hospitalized patients, low blood sugar -- also known as hypoglycemia -- is associated with increased short- and long-term mortality risk, according to a new study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism.
Noninvasive blood glucose monitoring device for people with diabetes in development
People with diabetes are one step closer to more easily checking their blood glucose levels with a non-invasive device for detecting and monitoring blood glucose levels, which is currently in development.
Bioengineers' sweat sensor monitors glucose
Researchers at the University of Texas at Dallas are sweating the small stuff in their efforts to develop a wearable device that can monitor an individual's glucose level via perspiration on the skin.
Combination therapy for type 1 diabetes improves blood glucose control
A combination of three medications -- dapagliflozin, liraglutide and insulin -- helped people with Type 1 diabetes improve blood sugar control and lose weight, according to a new study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism.
Glucose transporters blocked in bacterial meningitis
CHLA researchers report that glucose transporters, which transfer glucose from the blood to the brain, are inhibited by E. coli K1 during bacterial meningitis, leaving insufficient fuel for immune cells to fight off infection.

Related Blood Glucose Reading:

The Blood Glucose Diet: Discover Rapid, Healthy Weight Loss by Giving Up Sugar

Glucose Log Book: Blood Sugar Diabetic Glucose Monitoring Log : Daily Readings For 53 weeks. (Time)Before & (Time)After for Breakfast, Lunch , Dinner, ... Diabetic Glucose Record Book) (Volume 3)
by Phyliss Lewis (Author)

Blood Glucose Journal: Portable 6in x 9in Diabetes, Blood Sugar Log. Daily Readings For 53 weeks. Before & After for Breakfast, Lunch , Dinner, Snacks. Bedtime. With Daily Notes (Fitness)
by Journals For All (Author)

Blood Sugar Log Book: Food and Blood Sugar Journal, Diabetic Glucose Log, Blood Sugar Monitoring, Diabetes Journal Log Book, Diabetes Diary, 6 x 9 inch (Food and Blood Sugar for Diabetics) (Volume 1)
by John Book Publishing (Author)

Glucose Log Book: Your Glucose Monitoring Log - Record 2 years blood sugar levels (before & after) Professional Diabetic Glucose Log Book (Glucose Log Books) (Volume 1)
by Susan Log (Author)

Diabetic Glucose Log: Portable 6in x 9in Diabetes, Blood Sugar Log. Daily Readings For 53 weeks. Before & After for Breakfast, Lunch , Dinner, Snacks. Bedtime. With Daily Notes (Fitness)
by Journals For All (Author)

2 Years Diabetes Log Book: Blood Glucose Log Book; Daily Record Book For Tracking Glucose Blood Sugar Level; Diabetic Health Journal With Weekly Reviews; Medical Diary, Organizer & Logbook For 2 Years
by ZenWerkz (Author)

Glucose Log book: A Food & Blood Sugar Monitoring Diary: Abstact Blue Wave (Diabetes Journal Log Book) (Volume 3)
by F.J. Laurie (Author)

Diabetes Journal: Glucose Monitoring Record Book / Health Journal / Weight Loss Log (2-year Logbook for Recording Blood Glucose Levels and Tracking Health and Weight Loss)
by Journal Jungle Publishing (Author)

Blood Glucose 3 Year Log Book
by Vincent Van Gouache (Author)

Best Science Podcasts 2019

We have hand picked the best science podcasts for 2019. Sit back and enjoy new science podcasts updated daily from your favorite science news services and scientists.
Now Playing: TED Radio Hour

Bias And Perception
How does bias distort our thinking, our listening, our beliefs... and even our search results? How can we fight it? This hour, TED speakers explore ideas about the unconscious biases that shape us. Guests include writer and broadcaster Yassmin Abdel-Magied, climatologist J. Marshall Shepherd, journalist Andreas Ekström, and experimental psychologist Tony Salvador.
Now Playing: Science for the People

#513 Dinosaur Tails
This week: dinosaurs! We're discussing dinosaur tails, bipedalism, paleontology public outreach, dinosaur MOOCs, and other neat dinosaur related things with Dr. Scott Persons from the University of Alberta, who is also the author of the book "Dinosaurs of the Alberta Badlands".