Nav: Home

Metabolomic profiling of antibody response to periodontal pathogens

June 22, 2019

Alexandria, Va., USA - At the 97th General Session & Exhibition of the International Association for Dental Research (IADR), held in conjunction with the 48th Annual Meeting of the American Association for Dental Research (AADR) and the 43rd Annual Meeting of the Canadian Association for Dental Research (CADR), Jaakko Leskela, University of Helsinki, Finland, gave an oral presentation on "Metabolomic Profiling of Antibody Response to Periodontal Pathogens." The IADR/AADR/CADR General Session & Exhibition is held at the Vancouver Convention Centre West Building in Vancouver, BC, Canada from June 19-22, 2019.

Detection of periodontopathogen antibodies in circulation indicate exposure to periodontal pathogens. Inflammation, such as present in periodontal disease, has shown to modify lipoprotein metabolism and composition. In this study, Leskela and coauthors investigated the association between serum periodontopathogen antibody levels and various metabolite levels.

The study population consisted of 2,398 individuals whose serum antibody levels against P. gingivalis and A. actinomycetemcomitans were determined by multiserotype-ELISA. Nuclear Magnetic Resonance (NMR)-metabolomics platform determined a total of 68 metabolic variables, including lipoprotein particles, fatty acids, amino acids, metabolic substrates, glycoproteins and ketone bodies. P. gingivalis IgG antibody levels were associated negatively with Apolipoprotein A-I, HDL-bound cholesterol and especially cholesterol bound to larger HDL particles. There was negative association in P. gingivalis IgA antibody levels with Serum total cholesterol and A. actinomycetemcomitans IgG.

The authors concluded that exposure to the major periodontal pathogens, P. gingivalis and A. actinomycetemcomitans, is associated with a proatherogenic lipoprotein profile, especially low high-density lipoprotein cholesterol levels. These results are in line with previous findings where periodontal disease is shown to associate with atherogenic diseases.

This oral presentation, #2936, was held on Saturday, June 22, 2019 at 8:30 a.m. in Room 224 of the Vancouver Convention Centre West Building, Vancouver, BC, Canada.
About the International Association for Dental Research

The International Association for Dental Research (IADR) is a nonprofit organization with over 11,400 individual members worldwide, dedicated to: (1) advancing research and increasing knowledge for the improvement of oral health worldwide, (2) supporting and representing the oral health research community, and (3) facilitating the communication and application of research findings. To learn more, visit

International & American Associations for Dental Research

Related Periodontal Disease Articles:

Common periodontal pathogen may interfere with conception in women
According to a recent study, a common periodontal pathogen may delay concepcion in young women.
Columbia U. dental scientist receives IADR Award for periodontal research
Panos N. Papapanou, DDS, PhD, was recognized for contributions to areas of study including the epidemiology of periodontal diseases, their pathobiology, the assessment of microbial and host-derived risk factors, as well as the diseases' role as health stressor in heart disease and pregnancy complications. 
Collagen hydrogel scaffold and fibroblast growth factor-2 accelerate periodontal healing of class II
A new regenerative scaffold made of biosafe collagen hydrogel and collagensponge could possess the ability of retaining fibroblastic growth factor-2 (FGF2) and stimulate the periodontal tissue regeneration, according to new research published in The Open Dentistry Journal.
Study reveals new link between periodontal and cerebrovascular diseases
A new study has revealed a relationship between chronic periodontitis and lacunar infarct, two common diseases in the elderly.
Long-term marijuana use associated with periodontal disease
While using marijuana for as long as 20 years was associated with periodontal disease, it was not associated with some other physical health problems in early midlife at age 38, according to an article published online by JAMA Psychiatry.
More Periodontal Disease News and Periodontal Disease Current Events

Best Science Podcasts 2019

We have hand picked the best science podcasts for 2019. Sit back and enjoy new science podcasts updated daily from your favorite science news services and scientists.
Now Playing: TED Radio Hour

Do animals grieve? Do they have language or consciousness? For a long time, scientists resisted the urge to look for human qualities in animals. This hour, TED speakers explore how that is changing. Guests include biological anthropologist Barbara King, dolphin researcher Denise Herzing, primatologist Frans de Waal, and ecologist Carl Safina.
Now Playing: Science for the People

#534 Bacteria are Coming for Your OJ
What makes breakfast, breakfast? Well, according to every movie and TV show we've ever seen, a big glass of orange juice is basically required. But our morning grapefruit might be in danger. Why? Citrus greening, a bacteria carried by a bug, has infected 90% of the citrus groves in Florida. It's coming for your OJ. We'll talk with University of Maryland plant virologist Anne Simon about ways to stop the citrus killer, and with science writer and journalist Maryn McKenna about why throwing antibiotics at the problem is probably not the solution. Related links: A Review of the Citrus Greening...