Nav: Home

Clinical trials beginning for possible preeclampsia treatment

June 24, 2019

For over 20 years, a team of researchers at Lund University has worked on developing a drug against preeclampsia - a serious disorder which annually affects around 9 million pregnant women worldwide and is one of the main causes of death in both mothers and unborn babies.

Now the researchers have published a study in the journal Scientific Reports that opens up opportunities for further research towards a drug they hope will save the lives of many pregnant women in the future.

The study was conducted in a transgenic mouse model of preeclampsia, the results are important since they confirm previous studies by the research team showing that alpha-1-microglobulin has potential therapeutic effects in preeclampsia. Trials on patients have recently been launched.

"The treatment, based on the human body's own scavenger protein A1M (alpha-1-microglobulin) which is present in all vertebrates, has a good effect on the disease symptoms such as high blood pressure and protein leakage from the kidneys into the urine. We also observed an improvement in organ function in the kidneys and the placenta. We saw no indication of side effects. In the study now published using the preeclampsia mouse model, which best reflects the various stages of the disease during pregnancy, the mice develop serious preeclampsia in early pregnancy", says Stefan Hansson, professor of obstetrics and gynaecology at Lund University and senior consultant physician at Skåne University Hospital in Lund, who is the principal investigator behind the study together with colleagues including senior researcher Lena Erlandsson.

"This feels like a milestone in our research, as patient studies, known as Phase 1 clinical trials, began in the spring to establish the properties of A1M in order to develop a drug."

Together with his colleague, Bo Åkerström, professor of infection medicine, Stefan Hansson started the studies on A1M several years ago and observed that A1M stopped the leakage of protein in the kidneys. They also saw that the placenta was repaired and that the destroyed structures in the cells' smallest components were restored.

"In preeclampsia, the cells of the placenta looked approximately as though all the trees had been blown over in a storm, and after treatment with A1M they stood up again. When I saw that for the first time, I became a scientific believer", explains Stefan Hansson.

The date for a potential drug to see the light of day is still uncertain.

"Research takes time and costs a lot of money. Bo Åkerström has spent his entire professional life on understanding and describing the properties of the A1M protein and, in the last ten years, we have been studying it in the laboratory as a drug candidate. The results from the clinical trials will be crucial", concludes Stefan Hansson.
-end-
The study in brief:

Subject: Obstetrics
Basic research, translational research
Study design: experimental study, animal study (STOX-1-mouse model for pre-eclampsia), in vivo.

Further information:

Stefan Hansson holds patents related to the diagnosis and treatment of preeclampsia and is the co-founder of A1M Pharma AB and Preelumina Diagnostics, as well as a shareholder. Lena Erlandsson and Erik Hedström are shareholders of A1M Pharma.

Lund University

Related Clinical Trials Articles:

Review evaluates how AI could boost the success of clinical trials
In a review publishing July 17, 2019 in the journal Trends in Pharmacological Sciences, researchers examined how artificial intelligence (AI) could affect drug development in the coming decade.
Kidney patients are neglected in clinical trials
The exclusion of patients with kidney diseases from clinical trials remains an unsolved problem that hinders optimal care of these patients.
Clinical trials beginning for possible preeclampsia treatment
For over 20 years, a team of researchers at Lund University has worked on developing a drug against preeclampsia -- a serious disorder which annually affects around 9 million pregnant women worldwide and is one of the main causes of death in both mothers and unborn babies.
Underenrollment in clinical trials: Patients not the problem
The authors of the study published this month in the Journal of Clinical Oncology investigated why many cancer clinical trials fail to enroll enough patients.
When designing clinical trials for huntington's disease, first ask the experts
Progress in understanding the genetic mutation responsible for Huntington's disease (HD) and at least some molecular underpinnings of the disease has resulted in a new era of clinical testing of potential treatments.
New ALS therapy in clinical trials
New research led by Washington University School of Medicine in St.
Telemedicine helps improve participation in clinical trials
Videos and creative uses of other visuals provide a novel way to obtain informed consent during clinical trials to improve participants' understanding and retention of trial information, according to a study by Nemours Children's Health System presented at the American Thoracic Society (ATS) Annual Conference.
Not enough women included in some heart disease clinical trials
Women are underrepresented in clinical trials for heart failure, coronary artery disease and acute coronary syndrome but proportionately or overrepresented in trials for hypertension, atrial fibrillation and pulmonary arterial hypertension, when compared to incidence or prevalence of women within each disease population, according to a study in the Journal of the American College of Cardiology.
BU: Obese patients underrepresented in cancer clinical trials
A new review by Boston University School of Public Health researchers found that less than one-fifth of participants in cancer-related clinical trials are obese.
Are women really under-represented in clinical trials?
Several studies have reported a lack of gender diversity in clinical trials, with trials including mostly adult males; however, a recent review of publicly available registration data of clinical trials at the US Food and Drug Administration for the most frequently prescribed drug classes found no evidence of any systemic significant under-representation of women.
More Clinical Trials News and Clinical Trials Current Events

Trending Science News

Current Coronavirus (COVID-19) News

Top Science Podcasts

We have hand picked the top science podcasts of 2020.
Now Playing: TED Radio Hour

Teaching For Better Humans 2.0
More than test scores or good grades–what do kids need for the future? This hour, TED speakers explore how to help children grow into better humans, both during and after this time of crisis. Guests include educators Richard Culatta and Liz Kleinrock, psychologist Thomas Curran, and writer Jacqueline Woodson.
Now Playing: Science for the People

#556 The Power of Friendship
It's 2020 and times are tough. Maybe some of us are learning about social distancing the hard way. Maybe we just are all a little anxious. No matter what, we could probably use a friend. But what is a friend, exactly? And why do we need them so much? This week host Bethany Brookshire speaks with Lydia Denworth, author of the new book "Friendship: The Evolution, Biology, and Extraordinary Power of Life's Fundamental Bond". This episode is hosted by Bethany Brookshire, science writer from Science News.
Now Playing: Radiolab

Space
One of the most consistent questions we get at the show is from parents who want to know which episodes are kid-friendly and which aren't. So today, we're releasing a separate feed, Radiolab for Kids. To kick it off, we're rerunning an all-time favorite episode: Space. In the 60's, space exploration was an American obsession. This hour, we chart the path from romance to increasing cynicism. We begin with Ann Druyan, widow of Carl Sagan, with a story about the Voyager expedition, true love, and a golden record that travels through space. And astrophysicist Neil de Grasse Tyson explains the Coepernican Principle, and just how insignificant we are. Support Radiolab today at Radiolab.org/donate.