Nav: Home

Entry point for curbing the evolution of antibiotic resistance discovered

June 24, 2020

The team of Professor Tobias Bollenbach from the Institute for Biological Physics at the University of Cologne has published a study on a new approach to improving the effectiveness of antibiotics in bacterial infections. The study 'Highly parallel lab evolution reveals that epistasis can curb the evolution of antibiotic resistance,' on ways to controlling antibiotic resistance through targeted gene interactions has appeared in 'Nature Communications'.

'We wanted to know how genetic disorders in the bacterium E. coli interact with the later evolutionary adaptation to the drug,' said Bollenbach. Doctoral researcher Marta Lukačišinová developed a robotic platform together with Bollenbach and the technician Booshini Fernando with which hundreds of genetically altered Escherichia coli populations could be created simultaneously, and the course of their evolution investigated. 'Our most important result was that we found an entry point for suppressing the spontaneous development of resistance to the administered drug,' Lukačišinová added.

At first, the team identified a prototypical pattern in the development of resistance: Those bacterial strains that initially reacted more sensitively to drugs developed a greater resistance to the drug during the course of the evolutionary experiment. However, the researchers were particularly interested in the conditions under which this pattern is broken and virtually no resistance develops. The study showed that this happens when the bacterium exhibits certain functional disorders. The researchers identified the areas of membrane transport and chaperones, which play a decisive role in the error-free production of proteins. If these functions are not fully intact in the bacterium, an antibiotic can attack these areas much more effectively and improve its effectiveness in the long term. In the future, these molecular targets may help to improve antibiotics.

As head of the 'Biological Physics and Systems Biology' research group at the University of Cologne, Tobias Bollenbach is investigating new ways to minimize or even prevent the development of drug resistance.
-end-


University of Cologne

Related Evolution Articles:

A timeline on the evolution of reptiles
A statistical analysis of that vast database is helping scientists better understand the evolution of these cold-blooded vertebrates by contradicting a widely held theory that major transitions in evolution always happened in big, quick (geologically speaking) bursts, triggered by major environmental shifts.
Looking at evolution's genealogy from home
Evolution leaves its traces in particular in genomes. A team headed by Dr.
How boundaries become bridges in evolution
The mechanisms that make organisms locally fit and those responsible for change are distinct and occur sequentially in evolution.
Genome evolution goes digital
Dr. Alan Herbert from InsideOutBio describes ground-breaking research in a paper published online by Royal Society Open Science.
Paleontology: Experiments in evolution
A new find from Patagonia sheds light on the evolution of large predatory dinosaurs.
A window into evolution
The C4 cycle supercharges photosynthesis and evolved independently more than 62 times.
Is evolution predictable?
An international team of scientists working with Heliconius butterflies at the Smithsonian Tropical Research Institute (STRI) in Panama was faced with a mystery: how do pairs of unrelated butterflies from Peru to Costa Rica evolve nearly the same wing-color patterns over and over again?
Predicting evolution
A new method of 're-barcoding' DNA allows scientists to track rapid evolution in yeast.
Insect evolution: Insect evolution
Scientists at Ludwig-Maximilians-Universitaet (LMU) in Munich have shown that the incidence of midge and fly larvae in amber is far higher than previously thought.
Evolution of aesthetic dentistry
One of the main goals of dental treatment is to mimic teeth and design smiles in the most natural and aesthetic manner, based on the individual and specific needs of the patient.
More Evolution News and Evolution Current Events

Trending Science News

Current Coronavirus (COVID-19) News

Top Science Podcasts

We have hand picked the top science podcasts of 2020.
Now Playing: TED Radio Hour

Listen Again: The Power Of Spaces
How do spaces shape the human experience? In what ways do our rooms, homes, and buildings give us meaning and purpose? This hour, TED speakers explore the power of the spaces we make and inhabit. Guests include architect Michael Murphy, musician David Byrne, artist Es Devlin, and architect Siamak Hariri.
Now Playing: Science for the People

#576 Science Communication in Creative Places
When you think of science communication, you might think of TED talks or museum talks or video talks, or... people giving lectures. It's a lot of people talking. But there's more to sci comm than that. This week host Bethany Brookshire talks to three people who have looked at science communication in places you might not expect it. We'll speak with Mauna Dasari, a graduate student at Notre Dame, about making mammals into a March Madness match. We'll talk with Sarah Garner, director of the Pathologists Assistant Program at Tulane University School of Medicine, who takes pathology instruction out of...
Now Playing: Radiolab

What If?
There's plenty of speculation about what Donald Trump might do in the wake of the election. Would he dispute the results if he loses? Would he simply refuse to leave office, or even try to use the military to maintain control? Last summer, Rosa Brooks got together a team of experts and political operatives from both sides of the aisle to ask a slightly different question. Rather than arguing about whether he'd do those things, they dug into what exactly would happen if he did. Part war game part choose your own adventure, Rosa's Transition Integrity Project doesn't give us any predictions, and it isn't a referendum on Trump. Instead, it's a deeply illuminating stress test on our laws, our institutions, and on the commitment to democracy written into the constitution. This episode was reported by Bethel Habte, with help from Tracie Hunte, and produced by Bethel Habte. Jeremy Bloom provided original music. Support Radiolab by becoming a member today at Radiolab.org/donate.     You can read The Transition Integrity Project's report here.