Managing abnormal results on cervical cancer screening: ASCCP issues updated guidelines

June 25, 2020

June 25, 2020 - Replacing guidelines for managing women with abnormal results on cervical cancer screening test from 2012, new recommendations from ASCCP emphasize more precise management based on estimates of the patient's risk - enabling more personalized recommendations for diagnosis, treatment, and follow-up. The revised guidelines with updated recommendations are now available in the Journal of Lower Genital Tract Disease(JLGTD), official journal of ASCCP. The journal is published in the Lippincott portfolio by Wolters Kluwer.

The 2019 ASCCP Risk-Based Management Consensus Guidelines for Abnormal Cervical Cancer Screening Tests and Cancer Precursors were published in JLGTD on April 2, 2020. The recommendations reflect advances in understanding of the multiple factors affecting a woman's risk of developing cervical cancer or precancer. Rebecca Perkins, MD, of Boston University School of Medicine and Richard Guido, MD, of University of Pittsburgh are lead authors of the revised Guideline documents.

Focus on 'More Complete and Precise' Management Based on Risk Estimates in Women with Cervical Screening Abnormalities

The three available strategies for cervical cancer screening are primary HPV screening, co-testing with HPV testing and cervical cytology (Papanicolaou test), and cervical cytology alone. The 2012 Guidelines were an important step forward, based on the principle of "equal management for equal risk."

Developed by a consensus of 19 professional societies, federal agencies, and patient advocacy groups, convened by ASCCP, the new update "further aligns management recommendations with current understanding of HPV natural history and cervical carcinogenesis [cancer development]." Objectives of the 2019 ASCCP Risk-Based Management Consensus Guidelines include: Recognizing that the new guidelines bring together an abundance of data, ASCCP has launched a brand new app, and soon a website, to streamline the navigation of the new 2019 risk-based guidelines. These computer resources greatly simplify what would otherwise be a very complex system. More information on this technology can be found at

"The revised Guidelines provide a framework for incorporating new data and technologies as ongoing incremental recommendation revisions, minimizing time to implement changes that are beneficial to patient care," Drs. Perkins and Guido and colleagues conclude. They plan future studies to assess the costs, benefits, and effectiveness of the updated recommendations, along with a guideline dissemination strategy "to create a new national standard-of-care for management of abnormal cervical cancer screening test results."
Click here to read "2019 ASCCP Risk-Based Management Consensus Guidelines for Abnormal Cervical Cancer Screening Tests and Cancer Precursors."

DOI: 10.1097/LGT.0000000000000525

About the Journal of Lower Genital Tract Disease

The Journal of Lower Genital Tract Disease is the source for the latest science about benign and malignant conditions of the cervix, vagina, vulva, and anus. The Journal's mission is to promote excellence in the healthcare of people with anogenital and HPV-related diseases, to enable healthcare professionals to be well informed, to promote the exchange of ideas, to help advance standards in the conduct and reporting of health research, and to contribute to improving health of people worldwide.


ASCCP is a professional society for an interdisciplinary group of healthcare professionals including physicians, physician assistants, nurse practitioners, midwives and researchers, who are focused on improving lives through the prevention and treatment of anogenital and HPV-related diseases. For more information visit

About Wolters Kluwer

Wolters Kluwer (WKL) is a global leader in professional information, software solutions, and services for the clinicians, nurses, accountants, lawyers, and tax, finance, audit, risk, compliance, and regulatory sectors. We help our customers make critical decisions every day by providing expert solutions that combine deep domain knowledge with advanced technology and services.

Wolters Kluwer reported 2019 annual revenues of €4.6 billion. The group serves customers in over 180 countries, maintains operations in over 40 countries, and employs approximately 19,000 people worldwide. The company is headquartered in Alphen aan den Rijn, the Netherlands.

Wolters Kluwer provides trusted clinical technology and evidence-based solutions that engage clinicians, patients, researchers and students with advanced clinical decision support, learning and research and clinical intelligence. For more information about our solutions, visit and follow us on LinkedIn and Twitter @WKHealth.

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