Laparoscopy for colon cancer could offer long-term survival benefit over conventional surgery

June 27, 2002

A study in this week's issue of THE LANCET suggests that laparoscopy-assisted surgery to treat colon cancer could be more favourable than conventional open surgery, with the potential to reduce operative complications, hospital stay, and increase cancer-related survival in the longer term.

Colorectal cancer is the second leading cause of cancer-related death in Western countries. Prognosis associated with this disease has improved due to early diagnosis and changes in medical therapy. Adjuvant chemotherapy in colon cancer, radiotherapy, and introduction of the total mesorectal excision technique in rectal cancer have increased survival, especially in patients with advanced (stage III) tumours. Although early reports on laparoscopy-assisted colectomy (LAC) in patients with colon cancer suggest that it can reduce complications around the time of surgery, its influence on long-term outcomes is unknown. Antonio Lacy and colleagues from Hospital Clinic, Barcelona, Spain, aimed to compare the efficacy of LAC and open colectomy (OC) for treatment of non-metastatic colon cancer in terms of tumour recurrence and survival.

219 patients with colon cancer were randomly assigned to receive either LAC or open colectomy (OC). Patients in the LAC group required shorter stays in hospital (around five days) compared with patients given conventional surgery (eight day hospital stay); surgery-related complications were less frequent in patients given laparoscopy (12 of 111 patients) than those given open surgery (31 of 108 patients). Patients given laparoscopy had a 60% reduced risk of tumour relapse compared with those given open surgery. Patients in the LAC group also had a relative risk reduction of 50% of death from all causes compared with patients in the OC group.

Antonio Lacy comments: "our results show that LAC should be preferred to OC in patients with colon cancer because it reduces perioperative morbidity, shortens hospital stay, and prolongs cancer-related survival. This latter benefit was mainly due to differences in the subset of patients with stage III tumours, in whom LAC was also associated with lower tumour recurrence and longer overall survival. If these results were confirmed by ongoing multicentre randomised trials, LAC would become the standard surgical approach to patients with colon cancer."
Contact: Dr Antonio M Lacy, Surgery Department, Hospital Clinic, Villarroel 170, 08036 Barcelona, Spain; T) +34 93 227 5771; F) +34 93 227 9387; E)


Related Cancer Articles from Brightsurf:

New blood cancer treatment works by selectively interfering with cancer cell signalling
University of Alberta scientists have identified the mechanism of action behind a new type of precision cancer drug for blood cancers that is set for human trials, according to research published in Nature Communications.

UCI researchers uncover cancer cell vulnerabilities; may lead to better cancer therapies
A new University of California, Irvine-led study reveals a protein responsible for genetic changes resulting in a variety of cancers, may also be the key to more effective, targeted cancer therapy.

Breast cancer treatment costs highest among young women with metastic cancer
In a fight for their lives, young women, age 18-44, spend double the amount of older women to survive metastatic breast cancer, according to a large statewide study by the University of North Carolina at Chapel Hill.

Cancer mortality continues steady decline, driven by progress against lung cancer
The cancer death rate declined by 29% from 1991 to 2017, including a 2.2% drop from 2016 to 2017, the largest single-year drop in cancer mortality ever reported.

Stress in cervical cancer patients associated with higher risk of cancer-specific mortality
Psychological stress was associated with a higher risk of cancer-specific mortality in women diagnosed with cervical cancer.

Cancer-sniffing dogs 97% accurate in identifying lung cancer, according to study in JAOA
The next step will be to further fractionate the samples based on chemical and physical properties, presenting them back to the dogs until the specific biomarkers for each cancer are identified.

Moffitt Cancer Center researchers identify one way T cell function may fail in cancer
Moffitt Cancer Center researchers have discovered a mechanism by which one type of immune cell, CD8+ T cells, can become dysfunctional, impeding its ability to seek and kill cancer cells.

More cancer survivors, fewer cancer specialists point to challenge in meeting care needs
An aging population, a growing number of cancer survivors, and a projected shortage of cancer care providers will result in a challenge in delivering the care for cancer survivors in the United States if systemic changes are not made.

New cancer vaccine platform a potential tool for efficacious targeted cancer therapy
Researchers at the University of Helsinki have discovered a solution in the form of a cancer vaccine platform for improving the efficacy of oncolytic viruses used in cancer treatment.

American Cancer Society outlines blueprint for cancer control in the 21st century
The American Cancer Society is outlining its vision for cancer control in the decades ahead in a series of articles that forms the basis of a national cancer control plan.

Read More: Cancer News and Cancer Current Events is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to