Improved medical imaging improves cancer staging

June 28, 2020

Prof. TIAN Chao's group from the Department of Precision Machinery and Instrumentation, University of Science and Technology of China (USTC) of the Chinese Academy of Sciences (CAS) has made progress on the photoacoustic imaging for medical science. They improved the imaging quality and 3D construction of the photoacoustic imaging, and applied them to in vivo sentinel lymph node imaging. The studies were published in IEEE Transactions on Biomedical Engineering, Physical Review Applied and Journal of Biophotonics.

Sentinel lymph node biopsy (SLN) is currently the standard method for breast cancer staging, which includes preoperative lymph node tracing and intraoperative lymph node biopsy image-guiding. However, existing image guidance techniques suffer from a variety of limitations, such as harmful ionizing radiation, high cost, and poor imaging depth.

To solve these problems, Prof. TIAN's group proposed a contract-agent-enhanced photoacoustic imaging method, which used clinically-approved carbon nanoparticles as a contrast agent to trace SLN and guide fine needle aspiration biopsies, non-invasively and non-radioactively.

The researchers injected carbon nanoparticles (CNPs) into the forepaws of living rats to stain SLN. Subsequently, photoacoustic and ultrasound dual-modality imaging were performed simultaneously in real-time at the axillary area of the rats to trace the SLN and guide the biopsy.

Experiments showed that photoacoustics can image and display lymphatic vessel, lymph nodes, needles, etc. with high resolution and high signal-to-noise ratio, which can provide high-quality image guidance for lymph node biopsy.

In addition, spectroscopic analysis showed that CNPs are superior to indocyanine green, methylene blue and other contrast agents in optical absorption coefficient, photobleaching and photoacoustic conversion efficiency. It is an excellent tracer for identifying SLN by photoacoustic imaging and image-guided biopsies.

This study provides a practical approach for fine-needle aspiration biopsy in the SLN tracing and image guidance, and paves the way for clinical translation of photoacoustic SLN imaging.
-end-


University of Science and Technology of China

Related Lymph Nodes Articles from Brightsurf:

How to prevent the spread of tumor cells via the lymph vessels
Scientists from the German Cancer Research Center and the Mannheim Medical Faculty of the University of Heidelberg identified a new way to block the dangerous spread of tumor cells via lymphatic vessels.

Photoacoustic microscopy for identifying sentinel lymph nodes of breast cancer
Tumor metastatic sentinel lymph nodes is difficult to distinguish from normal or inflamed lymph nodes (Inf-LN).

Pigs grow new liver in lymph nodes, study shows
Hepatocytes -- the chief functional cells of the liver - are natural regenerators, and the lymph nodes serve as a nurturing place where they can multiply.

The secret of lymph: How lymph nodes help cancer cells spread
For decades, physicians have known that many kinds of cancer cells often spread first to lymph nodes before traveling to distant organs through the bloodstream.

Newly identified gut cells nurture lymph capillaries
IBS research team has identified new subsets of gut connective cells, which are crucial for lymphatic growth.The findings imply a crucial link between the physiology of intestinal environment and biological interactions between cell types.

Pathological regression of lymph nodes better predicts esophageal cancer survival
A team of researchers led by Osaka University established a new pathological grading system to evaluate the therapeutic effect of neoadjuvant chemotherapy (NAC) for metastatic lymph nodes (LNs) removed in esophageal cancer (EC) surgery, demonstrating that the system predicts recurrence and prognosis in EC patients better than conventional systems.

Unveiling how lymph nodes regulate immune response
The Hippo pathway keeps lymph nodes' development healthy. If impaired, lymph nodes become full of fat cells or fibrosis develops.

S1P molecule regulates dendritic cell localization and vascular integrity in lymph nodes
Researchers found that HEVs, which were deficient for the S1P-transporter Spinster-homologue-2, were unable to attract dendritic cells in order to trigger LTβr-signaling through cell-cell contact with HEVs.

Nanoparticle therapy targets lymph node metastases
Metastasis, in which cancer cells break free from the primary tumor and form tumors at other sites, worsens the prognosis for many cancer patients.

Lymph nodes can predict survival in patients with esophageal cancer
It is difficult for physicians to estimate recurrence and survival in patients with esophageal cancer.

Read More: Lymph Nodes News and Lymph Nodes Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.