Gene may inhibit smokers from quitting

June 30, 2003

Smokers with a particular genetic make-up (genotype) may find it harder to give up their habit, suggest Japanese researchers in Thorax.

The presence of a CYP2A6del allele, a specific form of the gene involved in processing nicotine in the body, may inhibit smokers from quitting, but it also seems to protect against the development of pulmonary emphysema, they conclude.

DNA was taken from 203 current or ex-smokers with suspected COPD and from 123 non-smoking healthy volunteers with few respiratory symptoms. All subjects were interviewed. Among the current or ex-smokers, the number of cigarettes consumed per day, the duration of smoking, and the time elapsed since quitting were recorded. CYP2A6 genotypes were determined in both groups.

The percentage of subjects with a CYP2A6del allele was lower in heavy smokers than in light smokers or non-smokers. It was also lower in ex-smokers than in current smokers.

The CYP2A6del allele appears to restrict the amount of lifelong cigarette consumption in heavy smokers but not in light smokers, say the authors. The CYP2A6del allele also appears to inhibit smokers from quitting smoking and acts as an intrinsic factor against the development of pulmonary emphysema, they write.

"These findings suggest that determination of the genotype will be useful in efficiently withdrawing patients from nicotine dependence in smoking cessation protocols with nicotine containing materials, and will give a new insight into the pathogenesis of smoking induced pulmonary emphysema," they conclude.


Related Smoking Articles from Brightsurf:

Smoking rates falling in adults, but stroke survivors' smoking rates remain steady
While the rate of Americans who smoke tobacco has fallen steadily over the last two decades, the rate of stroke survivors who smoke has not changed significantly.

What is your risk from smoking? Your network knows!
A new study from researchers at Penn's Annenberg School for Communication found that most people, smokers and non-smokers alike, were nowhere near accurate in their answers to questions about smoking's health effects.

Want to quit smoking? Partner up
Kicking the habit works best in pairs. That's the main message of a study presented today at EuroPrevent 2019, a scientific congress of the European Society of Cardiology (ESC).

Smoking and mortality in Asia
In this analysis of data from 20 studies conducted in China, Japan, South Korea, Singapore, Taiwan and India with more than 1 million participants, deaths associated with smoking continued to increase among men in Asia grouped by the years in which they were born.

Predictors of successfully quitting smoking among smokers registered at the quit smoking clinic at a public hospital in northeastern Malaysia
In the current issue of Family Medicine and Community Health, Nur Izzati Mohammad et al. consider how cigarette smoking is one of the risk factors leading to noncommunicable diseases such as cardiovascular and respiratory system diseases and cancer.

Restaurant and bar smoking bans do reduce smoking, especially among the highly educated
Smoking risk drops significantly in college graduates when they live near areas that have completely banned smoking in bars and restaurants, according to a new study in the American Journal of Epidemiology.

How the UK smoking ban increased wellbeing
Married women with children reported the largest increase in well-being following the smoking bans in the UK in 2006 and 2007 but there was no comparable increase for married men with children.

Smoking study personalizes treatment
A simple blood test is allowing Vanderbilt University Medical Center (VUMC) researchers to determine which patients should be prescribed varenicline (Chantix) to stop smoking and which patients could do just as well, and avoid side effects, by using a nicotine patch.

A biophysical smoking gun
While much about Alzheimer's disease remains a mystery, scientists do know that part of the disease's progression involves a normal protein called tau, aggregating to form ropelike inclusions within brain cells that eventually strangle the neurons.

A case where smoking helped
A mutation in the hemoglobin of a young woman in Germany was found to cause her mild anemia.

Read More: Smoking News and Smoking Current Events is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to