Nav: Home

Treating diseases at their origin

June 30, 2016

The protein STAT3 plays an important role in cell proliferation, survival and migration, making it an important modulator in inflammatory and malignant diseases. Mutations to the gene that signals its production can lead to a variety of diseases, including cancers and autoimmune disorders such as lymphoma, leukaemia, and childhood-onset autoimmunity. Understanding how STAT3 works is important to finding drugs that can treat these diseases.

Scientists at Hokkaido University in Japan investigated the molecular mechanisms that regulate STAT3 activity. They found that another protein, called ARL3, played an important role in the STAT3 pathway. By recognizing and strongly binding to STAT3, it facilitates the transportation of STAT3 into the nucleus and its accumulation there. In the nucleus, STAT3 then binds to special DNA sequences to regulate the turning on and off of certain genes.

Inhibiting the expression of ARL3 in cultured cells led to a decrease in STAT3's activity and consequently in the expression of its target genes. It also supressed STAT3-dependent proliferation of cells, indicating ARL3's important regulatory role on STAT3 and its pathways.

Based on previous studies, the team believes that ARL3 might also influence certain proteins involved in the transfer of STAT3 and other molecules into and out of the nucleus. Additionally, they believe that ARL3 might regulate STAT3 by facilitating its interaction with microtubules, which help to transport substances within the cell.

"Clarifying each step of STAT3 regulation is important because STAT3 is a key player in the pathogenesis of diverse human diseases and is a prime target for novel therapies," the researchers write in their study, published in the Journal of Biological Chemistry. "Specific inhibitors of the STAT3-ARL3 pathway are good candidates for the treatment of STAT3-related human diseases."
-end-


Hokkaido University

Related Protein Articles:

A direct protein-to-protein binding couples cell survival to cell proliferation
The regulators of apoptosis watch over cell replication and the decision to enter the cell cycle.
A protein that controls inflammation
A study by the research team of Prof. Geert van Loo (VIB-UGent Center for Inflammation Research) has unraveled a critical molecular mechanism behind autoimmune and inflammatory diseases such as rheumatoid arthritis, Crohn's disease, and psoriasis.
Resurrecting ancient protein partners reveals origin of protein regulation
After reconstructing the ancient forms of two cellular proteins, scientists discovered the earliest known instance of a complex form of protein regulation.
Sensing protein wellbeing
The folding state of the proteins in live cells often reflect the cell's general health.
Protein injections in medicine
One day, medical compounds could be introduced into cells with the help of bacterial toxins.
Discovery of an unusual protein
Scientists from Bremen discover an unusual protein playing a significant role in the Earth's nitrogen cycle.
Protein aggregation: Protein assemblies relevant not only for neurodegenerative disease
Amyloid fibrils play a crucial role in neurodegenerative illnesses. Scientists from Heinrich Heine University Düsseldorf (HHU) and Forschungszentrum Jülich have now been able to use cryo-electron microscopy (cryo-EM) to decode the spatial structure of the fibrils that are formed from PI3K SH3 domains - an important model system for research.
Old protein, new tricks: UMD connects a protein to antibody immunity for the first time
How can a protein be a major contributor in the development of birth defects, and also hold the potential to provide symptom relief from autoimmune diseases like lupus?
Infection-fighting protein also senses protein misfolding in non-infected cells
Researchers at the University of Toronto have uncovered an immune mechanism by which host cells combat bacterial infection, and at the same time found that a protein crucial to that process can sense and respond to misfolded proteins in all mammalian cells.
Quorn protein builds muscle better than milk protein
A study from the University of Exeter has found that mycoprotein, the protein-rich food source that is unique to Quorn products, stimulates post-exercise muscle building to a greater extent than milk protein.
More Protein News and Protein Current Events

Trending Science News

Current Coronavirus (COVID-19) News

Top Science Podcasts

We have hand picked the top science podcasts of 2020.
Now Playing: TED Radio Hour

Climate Mindset
In the past few months, human beings have come together to fight a global threat. This hour, TED speakers explore how our response can be the catalyst to fight another global crisis: climate change. Guests include political strategist Tom Rivett-Carnac, diplomat Christiana Figueres, climate justice activist Xiye Bastida, and writer, illustrator, and artist Oliver Jeffers.
Now Playing: Science for the People

#562 Superbug to Bedside
By now we're all good and scared about antibiotic resistance, one of the many things coming to get us all. But there's good news, sort of. News antibiotics are coming out! How do they get tested? What does that kind of a trial look like and how does it happen? Host Bethany Brookeshire talks with Matt McCarthy, author of "Superbugs: The Race to Stop an Epidemic", about the ins and outs of testing a new antibiotic in the hospital.
Now Playing: Radiolab

Speedy Beet
There are few musical moments more well-worn than the first four notes of Beethoven's Fifth Symphony. But in this short, we find out that Beethoven might have made a last-ditch effort to keep his music from ever feeling familiar, to keep pushing his listeners to a kind of psychological limit. Big thanks to our Brooklyn Philharmonic musicians: Deborah Buck and Suzy Perelman on violin, Arash Amini on cello, and Ah Ling Neu on viola. And check out The First Four Notes, Matthew Guerrieri's book on Beethoven's Fifth. Support Radiolab today at Radiolab.org/donate.