Nav: Home

Andalusian experts indicate new elements responsible for instability in chromosomes

June 30, 2017

Genome instability is the main risk factor in the development of tumours in humans. Understanding how, where, when and why these mutations are produced in DNA is one of the great objectives of the global scientific community. Therefore, a group of experts from the University of Seville and the Andalusian Center for Molecular Biology and Regenerative Medicine (Cabimer) has published a study that indicates a new element involved in this process: chromatin.

In the scientific article "Histone mutations separate R loops from genome instability induction" published in Molecular Cell, the researchers state that RNA joins with DNA by chance or because of a disease, the structure of the chromatin, the protein envelope of the chromosomes is altered, causing breaks in the DNA. Gene mutations involved in the transcription and transport of RNA also cause damage in DNA, which they have shown is caused by changes in the chromatin. In these circumstances, the DNA cannot replicate itself naturally, generating replication stress, mutations and chromosome mutations.

"By means of basic research on model organisms, we are trying to understand human genome instability to identify elements, which, in the future, might be able to be explored as targets of new anti-tumour medicines", explains the researcher responsible for the project and director of Cabimer, Andrés Aguilera. Also, he adds that "in this project, we have taken a step forward in showing that chromatin also plays a key role on some DNA mutations, especially those controlled by RNA. If we can show that this anomaly doesn't occur in healthy cells, we will be able to think about exploring these structures as possible therapeutic targets".

The project is part of the doctoral theses of Desiré García-Pichardo and Juan Carlos Martínez Cañas co-directed by Ana García-Rondón and Belén-Gómez-González, among other authors, and is part of the European research project, ERC Advanced, directed by Andrés Aguilera to increase knowledge about genetic instability produced by DNA-RNA hybrids. This project started in 2015, and will finish at the end of 2020 and is financed by more than two million euros from the European Commission.
-end-


University of Seville

Related Dna Articles:

Penn State DNA ladders: Inexpensive molecular rulers for DNA research
New license-free tools will allow researchers to estimate the size of DNA fragments for a fraction of the cost of currently available methods.
It is easier for a DNA knot...
How can long DNA filaments, which have convoluted and highly knotted structure, manage to pass through the tiny pores of biological systems?
How do metals interact with DNA?
Since a couple of decades, metal-containing drugs have been successfully used to fight against certain types of cancer.
Electrons use DNA like a wire for signaling DNA replication
A Caltech-led study has shown that the electrical wire-like behavior of DNA is involved in the molecule's replication.
Switched-on DNA
DNA, the stuff of life, may very well also pack quite the jolt for engineers trying to advance the development of tiny, low-cost electronic devices.
More Dna News and Dna Current Events

Best Science Podcasts 2019

We have hand picked the best science podcasts for 2019. Sit back and enjoy new science podcasts updated daily from your favorite science news services and scientists.
Now Playing: TED Radio Hour

Teaching For Better Humans
More than test scores or good grades — what do kids need to prepare them for the future? This hour, guest host Manoush Zomorodi and TED speakers explore how to help children grow into better humans, in and out of the classroom. Guests include educators Olympia Della Flora and Liz Kleinrock, psychologist Thomas Curran, and writer Jacqueline Woodson.
Now Playing: Science for the People

#534 Bacteria are Coming for Your OJ
What makes breakfast, breakfast? Well, according to every movie and TV show we've ever seen, a big glass of orange juice is basically required. But our morning grapefruit might be in danger. Why? Citrus greening, a bacteria carried by a bug, has infected 90% of the citrus groves in Florida. It's coming for your OJ. We'll talk with University of Maryland plant virologist Anne Simon about ways to stop the citrus killer, and with science writer and journalist Maryn McKenna about why throwing antibiotics at the problem is probably not the solution. Related links: A Review of the Citrus Greening...