Nav: Home

A revolutionary new treatment alternative to corneal transplantation

June 30, 2020

The team was co-led by May Griffith, a researcher at Maisonneuve-Rosemont Hospital Research Centre, which is affiliated with Université de Montréal and is part of the CIUSSS de l'Est-de-l'Île-de-Montréal.

The results of this multinational project have just been published in the journal Science Advances.

"Our work has led to an effective and accessible solution called LiQD Cornea to treat corneal perforations without the need for transplantation," said Griffith. She is also a full professor in the Department of Ophthalmology at Université de Montréal.

"This is good news for the many patients who are unable to undergo this operation due to a severe worldwide shortage of donor corneas," she said.

"Until now, patients on the waiting list have had their perforated corneas sealed with a medical-grade super glue, but this is only a short-term solution because it is often poorly tolerated in the eye, making transplantation necessary."

A synthetic, biocompatible and adhesive liquid hydrogel, LiQD Cornea, is applied as a liquid, but quickly adheres and gels within the corneal tissue. The LiQD Cornea promotes tissue regeneration, thus treating corneal perforations without the need for transplantation.

Griffith praised the work of her trainees, Christopher McTiernan and Fiona Simpson, and her collaborators from around the world who have helped create a potentially revolutionary treatment to help people with vision loss avoid going blind.

"Vision is the sense that allows us to appreciate how the world around us looks," said Griffith. "Allowing patients to retain this precious asset is what motivates our actions as researchers every day of the week."

For Sylvain Lemieux, president and CEO of the CIUSSS de l'Est-de-l'Île-de-Montréal, "this innovative treatment in ophthalmology confirms the level of expertise of the Centre universitaire d'ophtalmologie de l'Université de Montréal (CUO) at the Maisonneuve-Rosemont Hospital (HMR).

"The HMR has one of the largest teams of ophthalmologists in Quebec and one of the best-equipped ophthalmology research laboratories in North America," he said. "The hard work of our scientists and clinicians contributes daily to best practices and knowledge development.

"The multiple therapeutic possibilities resulting from our fundamental research, particularly in regenerative medicine, benefit and give hope to people suffering from ophthalmological diseases not only in Quebec, but in the rest of the world," he concluded.
-end-
The development of LiQD Cornea was supported by research grants from Euronanomedicine II - Swedish Research Council, Euronanomed III - FRQS and the Réseau de recherche en santé de la vision du Québec. UdeM-HMR trainees were supported by the Caroline Durand Foundation and support from the Dept. of Ophthalmology, UdeM, FRQNT and NSERC.

About May Griffith

Holder of a PhD in cell biology, May Griffith is director of the Corneal Regeneration and Biomaterials unit at the Maisonneuve-Rosemont Hospital Research Centre. She is full professor in the Department of Ophthalmology at Université de Montréal (UdeM), and is affiliated with the UdeM Institute of Biomedical Engineering and Centre hospitalier de l'Université de Montréal (CHUM). Dr. Griffith holds the Caroline Durand Foundation Chair in Cellular Therapy of Eye Diseases at UdeM, as well as the Canada Research Chair in Biomaterials and Stem Cells in Ophthalmology (Tier 1).

About the CIUSSS de l'Est-de l'Île-de-Montréal

The Centre intégré universitaire de santé et de services sociaux de l'Est-de-l'Île-de-Montréal (CIUSSS-Est) includes Maisonneuve-Rosemont Hospital, Santa Cabrini Hospital, the Canadian-Polish Welfare Institute, the Institut universitaire en santé mentale de Montréal, and the Saint-Léonard, Saint-Michel, Pointe-de-l'Île, and Lucille-Teasdale Health and Social Service Centres (CSSSs). Affiliated with Université de Montréal, the CIUSSS-Est combines the missions of teaching, assessment, and research of doctors and health professionals with excellence in health care delivery.

University of Montreal

Related Transplantation Articles:

Elderly patients also benefit from kidney transplantation
So far, kidney transplantation has generally not been offered to elderly patients (>75 years) because of the perioperative risks.
New material will allow abandoning bone marrow transplantation
Scientists from the National University of Science and Technology 'MISIS' developed nanomaterial, which will be able to restore the internal structure of bones damaged due to osteoporosis and osteomyelitis.
Fewer medical tests -- timely listing for transplantation
Younger patients would benefit greatly from kidney transplantation. Their expected remaining lifetime may even be doubled by having a transplant.
Uterus transplantation -- ethically just as problematic as altruistic surrogacy
In 2014, the first child to have been gestated in a donated uterus was born.
Advancing transplantation: Hepatitis C-infected organs safe for transplantation when followed by antiviral treatment
Twenty patients at Penn Medicine have been cured of the hepatitis C virus (HCV) following lifesaving kidney transplants from deceased donors who were infected with the disease, according to a study published today in Annals of Internal Medicine.
Transplantation followed by antiviral therapy cured hepatitis C
Twenty patients who received kidneys transplanted from hepatitis C virus (HCV)-infected donors experienced HCV cure, good quality of life, and excellent renal function at one year.
The Journal of Heart and Lung Transplantation: 50 years of heart transplantation progress
This month marks the 50th anniversary of the world's first human heart transplant performed at Groote Schuur Hospital in Cape Town by South African surgeon, Christiaan Barnard.
Older donor lungs should be considered for transplantation
With a scarcity of lungs available for transplantation, the use of lungs from donors older than age 60 has been shown to achieve reasonable outcomes and should be considered as a viable option, according to research published online today in The Annals of Thoracic Surgery.
VA patients face disparities in kidney transplantation
From 2004 to 2016, VA patients had lower rates of transplantation compared with patients with Medicare or private insurance.
Hepatocellular carcinoma: Resection vs. transplantation
Liver transplantation is the gold standard for treating early hepatocellular cancers.
More Transplantation News and Transplantation Current Events

Trending Science News

Current Coronavirus (COVID-19) News

Top Science Podcasts

We have hand picked the top science podcasts of 2020.
Now Playing: TED Radio Hour

Our Relationship With Water
We need water to live. But with rising seas and so many lacking clean water – water is in crisis and so are we. This hour, TED speakers explore ideas around restoring our relationship with water. Guests on the show include legal scholar Kelsey Leonard, artist LaToya Ruby Frazier, and community organizer Colette Pichon Battle.
Now Playing: Science for the People

#568 Poker Face Psychology
Anyone who's seen pop culture depictions of poker might think statistics and math is the only way to get ahead. But no, there's psychology too. Author Maria Konnikova took her Ph.D. in psychology to the poker table, and turned out to be good. So good, she went pro in poker, and learned all about her own biases on the way. We're talking about her new book "The Biggest Bluff: How I Learned to Pay Attention, Master Myself, and Win".
Now Playing: Radiolab

Uncounted
First things first: our very own Latif Nasser has an exciting new show on Netflix. He talks to Jad about the hidden forces of the world that connect us all. Then, with an eye on the upcoming election, we take a look back: at two pieces from More Perfect Season 3 about Constitutional amendments that determine who gets to vote. Former Radiolab producer Julia Longoria takes us to Washington, D.C. The capital is at the heart of our democracy, but it's not a state, and it wasn't until the 23rd Amendment that its people got the right to vote for president. But that still left DC without full representation in Congress; D.C. sends a "non-voting delegate" to the House. Julia profiles that delegate, Congresswoman Eleanor Holmes Norton, and her unique approach to fighting for power in a virtually powerless role. Second, Radiolab producer Sarah Qari looks at a current fight to lower the US voting age to 16 that harkens back to the fight for the 26th Amendment in the 1960s. Eighteen-year-olds at the time argued that if they were old enough to be drafted to fight in the War, they were old enough to have a voice in our democracy. But what about today, when even younger Americans are finding themselves at the center of national political debates? Does it mean we should lower the voting age even further? This episode was reported and produced by Julia Longoria and Sarah Qari. Check out Latif Nasser's new Netflix show Connected here. Support Radiolab today at Radiolab.org/donate.