Nav: Home

MIPT bioinformaticians find way to personalize drug prescription against stomach cancer

June 30, 2020

Researchers from the Moscow Institute of Physics and Technology and their colleagues have developed the first technique for personalizing stomach cancer therapy based on RNA sequencing of tumor cells. The study, supported by the Russian Science Foundation, was published in Cold Spring Harbor Molecular Case Studies.

Stomach cancer is the fifth-deadliest oncological disease. It is seldom diagnosed in the early stages, which complicates treatment. There are several treatment options available that rely on chemotherapy and therapeutic antibodies. However, patient response is often unpredictable, so personalized therapies with drug prescriptions tailored to individual cases are required.

Problematic recurrent tumors of the stomach are treated with therapeutic antibodies. They block the receptors on the surface of cells that are responsible for receiving growth-promoting signals. Without them, cell division stops and the tumor does not increase in size. Preventing the growth of blood vessels is particularly important, because they supply nutrients and oxygen to the tumor. Ramucirumab is a therapeutic antibody used to disrupt the growth of blood vessels in tumor tissue. The efficacy of this drug varies widely from patient to patient.

MIPT bioinformaticians and their colleagues from medical research centers and the industry have proposed that a patient's data on the gene expression levels in cancer be used to evaluate ramucirumab efficacy in each individual case.

"This is virtually the first published case of successful [ramucirumab] prescription to patients with gastric cancer, which was not random but rather informed by the analysis of the molecular markers we track based on RNA sequencing," said Maxim Sorokin, a senior researcher at the MIPT Laboratory for Translational Genomic Bioinformatics and the head of the Bioinformatics Department at Oncobox.

Combined with information technology, modern molecular biology methods enable researchers to collect qualitative data on the expression of every gene in a cell. By analyzing these data, it is possible to find the key to diagnosing oncological diseases and predicting the efficacy of their treatment.
-end-
The study reported in this story was co-authored by researchers from MIPT, Sechenov University, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of RAS, Blokhin National Medical Research Center of Oncology, Vitamed Clinical Center, Vladimirsky Moscow Regional Research Clinical Institute, and Oncobox.

Moscow Institute of Physics and Technology

Related Cancer Articles:

UCI researchers uncover cancer cell vulnerabilities; may lead to better cancer therapies
A new University of California, Irvine-led study reveals a protein responsible for genetic changes resulting in a variety of cancers, may also be the key to more effective, targeted cancer therapy.
Breast cancer treatment costs highest among young women with metastic cancer
In a fight for their lives, young women, age 18-44, spend double the amount of older women to survive metastatic breast cancer, according to a large statewide study by the University of North Carolina at Chapel Hill.
Cancer mortality continues steady decline, driven by progress against lung cancer
The cancer death rate declined by 29% from 1991 to 2017, including a 2.2% drop from 2016 to 2017, the largest single-year drop in cancer mortality ever reported.
Stress in cervical cancer patients associated with higher risk of cancer-specific mortality
Psychological stress was associated with a higher risk of cancer-specific mortality in women diagnosed with cervical cancer.
Cancer-sniffing dogs 97% accurate in identifying lung cancer, according to study in JAOA
The next step will be to further fractionate the samples based on chemical and physical properties, presenting them back to the dogs until the specific biomarkers for each cancer are identified.
Moffitt Cancer Center researchers identify one way T cell function may fail in cancer
Moffitt Cancer Center researchers have discovered a mechanism by which one type of immune cell, CD8+ T cells, can become dysfunctional, impeding its ability to seek and kill cancer cells.
More cancer survivors, fewer cancer specialists point to challenge in meeting care needs
An aging population, a growing number of cancer survivors, and a projected shortage of cancer care providers will result in a challenge in delivering the care for cancer survivors in the United States if systemic changes are not made.
New cancer vaccine platform a potential tool for efficacious targeted cancer therapy
Researchers at the University of Helsinki have discovered a solution in the form of a cancer vaccine platform for improving the efficacy of oncolytic viruses used in cancer treatment.
American Cancer Society outlines blueprint for cancer control in the 21st century
The American Cancer Society is outlining its vision for cancer control in the decades ahead in a series of articles that forms the basis of a national cancer control plan.
Oncotarget: Cancer pioneer employs physics to approach cancer in last research article
In the cover article of Tuesday's issue of Oncotarget, James Frost, MD, PhD, Kenneth Pienta, MD, and the late Donald Coffey, Ph.D., use a theory of physical and biophysical symmetry to derive a new conceptualization of cancer.
More Cancer News and Cancer Current Events

Trending Science News

Current Coronavirus (COVID-19) News

Top Science Podcasts

We have hand picked the top science podcasts of 2020.
Now Playing: TED Radio Hour

Warped Reality
False information on the internet makes it harder and harder to know what's true, and the consequences have been devastating. This hour, TED speakers explore ideas around technology and deception. Guests include law professor Danielle Citron, journalist Andrew Marantz, and computer scientist Joy Buolamwini.
Now Playing: Science for the People

#576 Science Communication in Creative Places
When you think of science communication, you might think of TED talks or museum talks or video talks, or... people giving lectures. It's a lot of people talking. But there's more to sci comm than that. This week host Bethany Brookshire talks to three people who have looked at science communication in places you might not expect it. We'll speak with Mauna Dasari, a graduate student at Notre Dame, about making mammals into a March Madness match. We'll talk with Sarah Garner, director of the Pathologists Assistant Program at Tulane University School of Medicine, who takes pathology instruction out of...
Now Playing: Radiolab

How to Win Friends and Influence Baboons
Baboon troops. We all know they're hierarchical. There's the big brutish alpha male who rules with a hairy iron fist, and then there's everybody else. Which is what Meg Crofoot thought too, before she used GPS collars to track the movements of a troop of baboons for a whole month. What she and her team learned from this data gave them a whole new understanding of baboon troop dynamics, and, moment to moment, who really has the power.  This episode was reported and produced by Annie McEwen. Support Radiolab by becoming a member today at Radiolab.org/donate.