Leptin, A Fat Cell Hormone, Is Abnormally Regulated In Anorexia Nervosa

June 30, 1997

Leptin levels in patients with anorexia nervosa are reduced in the acute stage and elevated upon short-term weight restoration

J Hebebrand, WF Blum, N Barth, H Coners, P Englaro, A Juul, A Ziegler, A Warnke, W Rascher, H Remschmidt Departments of Child and Adolescent Psychiatry and Medical Biometry, University of Marburg; Lilly GmbH, Germany; Children's Hospital, University of Giessen; Department of Child and Adolescent Psychiatry, University of WYrzburg, Germany, and Rikshospitalet, Copenhagen, Denmark.

In female patients with acute anorexia nervosa, plasma leptin concentrations are well below those of female controls matched for age, body mass index, and/or percent body fat. The low levels presumably reflect the restricted energy intake of these patients. The reduced leptin synthesis is likely to be involved in the pathogenesis of amenorrhea and the reduced metabolic state of acutely ill individuals. Weight gain leads to steep increases in leptin synthesis, resulting in leptin plasma levels that peak at values well in excess of those of female controls. This phenomenon might underlie increased energy expenditure which has previously been observed upon short-term weight restoration. At this stage patients might therefore be especially vulnerable to renewed weight loss. Leptin levels drop into the control range several weeks after attainment of the target weight, indicating normalization. In patients who subsequently lose weight anew leptin levels again drop below the control range.

For further information, please contact the corresponding author, Professor Johannes Hebebrand at the University of Marburg, Germany; e-mail: Hebebran@post.med.uni-marburg.de; Tel.: +49-6421-286466; Fax: +49-6421-283056. The relevance of these findings is independently reviewed in an editorial to be published in the same issue of Molecular Psychiatry by the journal editor, Julio Licinio, M.D.; phone: 301-496-6885; FAX: 301-402-1561; e-mail: licinio@nih.gov
-end-


Molecular Psychiatry

Related Adolescent Psychiatry Articles from Brightsurf:

The Lancet Psychiatry: First UK-wide study describes brain complications in some patients with severe COVID-19
A study of 153 patients treated in UK hospitals during the acute phase of the COVID-19 pandemic describes a range of neurological and psychiatric complications that may be linked to the disease and is published today in The Lancet Psychiatry journal.

The Lancet Child & Adolescent Health: Experts call for more awareness of the potential impact of physical distancing on adolescent peer relationships and social development
Authors of an opinion piece, based on a review of evidence and published in The Lancet Child and Adolescent Health journal, are urging policymakers to consider the effects of physical distancing measures introduced to tackle the spread of COVID-19 on young people's social development and wellbeing.

Revisiting the potential of using psychedelic drugs in psychiatry
Before they were banned about a half century ago, psychedelic drugs like LSD and psilocybin showed promise for treating conditions including alcoholism and some psychiatric disorders.

The Lancet Psychiatry: US study reports rate of suicidal ideation in children, and risk and protective factors
Around eight in every 100 children (8.4%; 673/7,994) aged 9-10 years in the USA report suicidal ideation (temporarily or regularly thinking about, considering, or planning suicide), according to a new nationally representative observational study of almost 8,000 children aged 9-10 years in the USA, published in The Lancet Psychiatry journal.

Psychiatry: Five clearly defined patterns
Psychiatrists led by Nikolaos Koutsouleris from Ludwig-Maximilians-Universitaet (LMU) in Munich have used a computer-based approach to assign psychotic patients diagnosed as bipolar or schizophrenic to five different subgroups.

The Lancet Psychiatry: Life-course-persistent antisocial behaviour may be associated with differences in brain structure
Individuals who exhibit life-course-persistent antisocial behaviour - for example, stealing, aggression and violence, bullying, lying, or repeated failure to take care of work or school responsibilities - may have thinner cortex and smaller surface area in regions of the brain previously implicated in studies of antisocial behaviour more broadly, compared to individuals without antisocial behaviour, according to an observational study of 672 participants published in The Lancet Psychiatry journal.

The Lancet Psychiatry: Abortion does not increase a woman's risk of attempting suicide
Policies based on the notion that undergoing an abortion causes or increases women's risk of suicide attempts are misinformed, according to the results of a 17-year-long observational study including more than half a million 18 to 36-year-old Danish women who had a first, first-trimester abortion, published in The Lancet Psychiatry journal.

How artificial intelligence can transform psychiatry
Scientists have developed a new mobile app that categorizes mental health status based on speech patterns.

The Lancet Psychiatry: Improved support after self-harm needed to reduce suicide risk
To reduce the high risk of suicide after hospital attendance for self-harm, improved clinical management is needed for all patients - including comprehensive assessment of the patients' mental state, needs, and risks, as well as implementation of risk reduction strategies, including safety planning.

The Lancet Psychiatry: Insufficient evidence that medicinal cannabinoids improve mental health
The most comprehensive analysis of medicinal cannabinoids and their impact on six mental health disorders -- combining 83 studies including 3,000 people -- suggests that the use of cannabinoids for mental health conditions cannot be justified based on the current evidence.

Read More: Adolescent Psychiatry News and Adolescent Psychiatry Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.