Caution urged in research with angiogenesis therapy

July 02, 2001

DALLAS, - Using gene therapy to spur new blood vessel growth and improve blood flow is a promising treatment for clogged arteries leading to the heart or legs. However, the technique, called angiogenesis, should be pursued with caution, researchers write in a "Current Perspective" article in today's Circulation: Journal of the American Heart Association.

"We are optimistic that ultimately angiogenesis therapy will prove effective and safe," the researchers write. However, researchers "need to be aware of the biological effects of each angiogenic agent being proposed for clinical studies and accept the likelihood that complications will occur." Angiogenesis was essentially unknown just a decade ago, the authors write, and today there is great excitement about the major impact it may have on the treatment of clogged arteries.

But for all the promise of angiogenesis, there are inherent, potentially serious side effects that have not been discussed in-depth in the medical community.

Triggering growth in abnormal tissue or of abnormal blood vessels, increasing the growth of artery-clogging plaque and stimulating the inflammatory response are among potential complications. The authors say these possible complications may not occur in the clinical setting, and they are hopeful that angiogenesis ultimately will live up to its promise. But they also emphasize that researchers must be aware that there are complications that can occur.
-end-
The review was funded in part by the National Institutes of Health. Stephen E. Epstein, M.D., executive director, Cardiovascular Research Institution (CRI) and director, Vascular Biology Laboratory at CRI, Washington, DC; 202-877-7460; e-mail: stephen.epstein@medstar.net

CONTACT: For journal copies only, please call: 214-706-1396. For other information, call: Carole Bullock: 214-706-1279; Bridgette McNeill: 214-706-1135.

NR01-1306 (Circ/Epstein)

American Heart Association

Related Gene Therapy Articles from Brightsurf:

Risk of AAV mobilization in gene therapy
New data highlight safety concerns for the replication of recombinant adeno-associated viral (rAAV) vectors commonly used in gene therapy.

Discovery challenges the foundations of gene therapy
An article published today in Science Translational Medicine by scientists from Children's Medical Research Institute has challenged one of the foundations of the gene therapy field and will help to improve strategies for treating serious genetic disorders of the liver.

Gene therapy: Novel targets come into view
Retinitis pigmentosa is the most prevalent form of congenital blindness.

Gene therapy targets inner retina to combat blindness
Batten disease is a group of fatal, inherited lysosomal storage disorders that predominantly affect children.

New Human Gene Therapy editorial: Concern following gene therapy adverse events
Response to the recent report of the deaths of two children receiving high doses of a gene therapy vector (AAV8) in a Phase I trial for X-linked myotubular myopathy (MTM).

Restoring vision by gene therapy
Latest scientific findings give hope for people with incurable retinal degeneration.

Gene therapy/gene editing combo could offer hope for some genetic disorders
A hybrid approach that combines elements of gene therapy with gene editing converted an experimental model of a rare genetic disease into a milder form, significantly enhancing survival, shows a multi-institutional study led by the University of Pennsylvania and Children's National Hospital in Washington, D.C.

New technology allows control of gene therapy doses
Scientists at Scripps Research in Jupiter have developed a special molecular switch that could be embedded into gene therapies to allow doctors to control dosing.

Gene therapy: Development of new DNA transporters
Scientists at the Institute of Pharmacy at Martin Luther University Halle-Wittenberg (MLU) have developed new delivery vehicles for future gene therapies.

Gene therapy promotes nerve regeneration
Researchers from the Netherlands Institute for Neuroscience and the Leiden University Medical Center have shown that treatment using gene therapy leads to a faster recovery after nerve damage.

Read More: Gene Therapy News and Gene Therapy Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.