Reduced lung capacity linked to cardiovascular disease by inflammation

July 02, 2007

People who have a reduced lung capacity may have a greater risk of heart attack and stroke because they show evidence of inflammation, reveals a study published online ahead of print in Thorax.

This association is not related to smoking, respiratory diseases or obesity.

The New Zealand researchers took measurements of lung capacity and inflammation in 1,000 adults aged between 26 and 32 years. To measure inflammation, they looked at the amount of C-reactive protein (CRP), an inflammatory marker, circulating in the blood. Higher levels of CRP were found in the blood of those with smaller lung capacities.

Although increased levels of markers for inflammation have previously been found in the blood of older people with reduced lung function and chronic obstructive pulmonary disease (COPD), the authors say: 'To our knowledge, this is the first report of an inverse association between lung function and CRP in young adults.'

The results showed that this association was not related to smoking or lung disease, because the relationship existed even in people who had never smoked and had no respiratory disease. It was also not explained by obesity, which is often associated with raised inflammatory markers.

It has been suggested that an increased risk of cardiovascular disease may exist in older adults with COPD because inflammation is a risk factor for hardening of the arteries or atherosclerosis.

However, this study found an association between higher serum CRP and lower lung function in adults as young as 26 years, who the authors say are very unlikely to have developed either clinically significant atherosclerosis or COPD.

They say: 'These findings indicate that the association between lower lung function and increased inflammation predates the development of either chronic lung disease or clinically significant atherosclerosis.

'Establishing whether systemic inflammation leads to reduced lung function or whether lower lung function leads to inflammation is difficult, but this research suggests that the association between poor lung function and cardiovascular disease may be mediated by an inflammatory mechanism.'
-end-


BMJ Specialty Journals

Related Heart Attack Articles from Brightsurf:

Top Science Tip Sheet on heart failure, heart muscle cells, heart attack and atrial fibrillation results
Newly discovered pathway may have potential for treating heart failure - New research model helps predict heart muscle cells' impact on heart function after injury - New mass spectrometry approach generates libraries of glycans in human heart tissue - Understanding heart damage after heart attack and treatment may provide clues for prevention - Understanding atrial fibrillation's effects on heart cells may help find treatments - New research may lead to therapy for heart failure caused by ICI cancer medication

Molecular imaging identifies link between heart and kidney inflammation after heart attack
Whole body positron emission tomography (PET) has, for the first time, illustrated the existence of inter-organ communication between the heart and kidneys via the immune system following acute myocardial infarction.

Muscle protein abundant in the heart plays key role in blood clotting during heart attack
A prevalent heart protein known as cardiac myosin, which is released into the body when a person suffers a heart attack, can cause blood to thicken or clot--worsening damage to heart tissue, a new study shows.

New target identified for repairing the heart after heart attack
An immune cell is shown for the first time to be involved in creating the scar that repairs the heart after damage.

Heart cells respond to heart attack and increase the chance of survival
The heart of humans and mice does not completely recover after a heart attack.

A simple method to improve heart-attack repair using stem cell-derived heart muscle cells
The heart cannot regenerate muscle after a heart attack, and this can lead to lethal heart failure.

Mount Sinai discovers placental stem cells that can regenerate heart after heart attack
Study identifies new stem cell type that can significantly improve cardiac function.

Fixing a broken heart: Exploring new ways to heal damage after a heart attack
The days immediately following a heart attack are critical for survivors' longevity and long-term healing of tissue.

Heart patch could limit muscle damage in heart attack aftermath
Guided by computer simulations, an international team of researchers has developed an adhesive patch that can provide support for damaged heart tissue, potentially reducing the stretching of heart muscle that's common after a heart attack.

How the heart sends an SOS signal to bone marrow cells after a heart attack
Exosomes are key to the SOS signal that the heart muscle sends out after a heart attack.

Read More: Heart Attack News and Heart Attack Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.