Apgar score effective in assessing health of preterm infants

July 02, 2020

The vitality of preterm infants should be assessed with an Apgar score, a tool used to measure the health of newborns immediately after birth. That is the conclusion by researchers at Karolinska Institutet in Sweden who in a large observational study examined the value of Apgar scores for preterm infants. The findings are published in the New England Journal of Medicine.

The so-called Apgar score has been used since the 1950s to quickly assess the vitality of the infant soon after birth. Doctors and midwifes measure five parameters in the infant--heart activity, respiration, muscle tone, irritability and color--and give each parameter a score from 0-2. The total score can thus range from 0 to 10, where a higher number indicates better health and a greater chance of survival.

However, some have questioned the value of the Apgar score in preterm infants, since the immaturity of these infants may lead to lower scores compared with infants born at term. Therefore, the researchers in this study wanted to find out if the Apgar score could be used to predict the mortality risk of preterm infants during the first four weeks of life (the neonatal period).

Using Swedish nationwide register data, the researchers studied 113,000 non-malformed infants born after 22 to 36 weeks of pregnancy in the years 1992-2016. The risk of neonatal mortality was calculated for Apgar scores at five and ten minutes after birth, and separate analyses were performed for infants born at 22-24, 25-27, 28-31, 32-34 and 35-36 gestational weeks.

A total of 1,986 (1.8 percent) preterm infants died in the neonatal period. As expected, the neonatal death rate sharply increased with shorter pregnancy length, from 0.2 percent for infants born at 36 weeks to 76.5 percent for those born at 22 weeks. Regardless of pregnancy length, the risk of neonatal death increased with a lower Apgar score. For children born very prematurely, a lower Apgar score significantly increased the absolute risk of neonatal mortality. Even a slight increase in Apgar score from five to ten minutes after birth was associated with a lower risk of neonatal death.

"Our results show the importance of registering Apgar score also in preterm infants," says Sven Cnattingius, senior professor at the Department of Medicine, Solna, Karolinska Institutet, and the study's corresponding author. "It is important that infants with reduced scores receive full clinical attention regardless of gestational age."

"Heart activity and breathing are the cornerstones of the Apgar assessment," says co-author Stefan Johansson, associate professor at the Department of Medicine, Solna, Karolinska Institutet and neonatologist at the Sachsska children and youth hospital in Stockholm. "Our research indicates that the chance of survival increases the better you are at stabilizing the premature baby's circulation and breathing immediately after birth."

The researchers considered several confounding factors that could impact the outcome, including the mother's age, smoking, weight, blood-pressure, infant's mode of delivery and year of birth. The researchers note that the study is based on Swedish conditions and that the results may be different in other countries.

"Although it is frustrating that we usually cannot pinpoint the causes of a reduced Apgar score, we need to embrace that the score is, independent of gestational age, the best available tool we have to evaluate the newborn's health in the delivery room," says Neda Razaz, assistant professor in the same department.

Around 115,000 non-malformed children are born in Sweden annually, and slightly more than 5 percent are born preterm. Of these, around 150 children die during the neonatal period, of which around 100 are born preterm.
The study was funded by grants from the Swedish Research Council for Health, Working Life and Welfare and by Karolinska Institutet's Distinguished Professor Award to Sven Cnattingius.

Publication: "Apgar score and neonatal mortality risk in preterm infants," Cnattingius S, Johansson S, Razaz N. New England Journal of Medicine, online July 1, 2020, doi: 10.1056/NEJMoa1915075

Karolinska Institutet

Related Pregnancy Articles from Brightsurf:

COVID-19 has a prolonged effect for many during pregnancy
Symptoms for pregnant women with COVID-19 can be prolonged, lasting two months or longer for a quarter of the women who participated in a national study led by UC San Francisco and UCLA.

Relaxed through pregnancy
A group of researchers from Charité - Universitätsmedizin Berlin have been able to show that maternal psychological wellbeing during pregnancy has a positive effect on newborn infants.

Trajectories of antidepressant medication use during pregnancy
In an analysis of women who started pregnancy when taking antidepressant medications, investigators identified three trajectories of antidepressant dispensing during pregnancy: more than half stopped their treatment, a quarter maintained their treatment throughout pregnancy, and one-fifth discontinued it for a minimum of three months and then resumed it during the postpartum period.

Are women using e-cigarettes during preconception and/or pregnancy?
A new study of 1,365 racially/ethnically diverse, low-income pregnant women found that 4% reported e-cigarette use.

A better pregnancy test for whales
To determine whale pregnancy, researchers have relied on visual cues or hormone tests of blubber collected via darts, but the results were often inconclusive.

Cannabis use during pregnancy
The large health care system Kaiser Permanente Northern California provides universal screening for prenatal cannabis use in women during pregnancy by self-report and urine toxicology testing.

Questions and answers about cannabis use during pregnancy
A new study shows that women have many medical questions about the use of cannabis both before and during pregnancy, and during the postpartum period while breastfeeding.

The effect of taking antidepressants during pregnancy
Exposure to antidepressants during pregnancy and the first weeks of life can alter sensory processing well into adulthood, according to research in mice recently published in eNeuro.

Is ivermectin safe during pregnancy?
Is it safe to give ivermectin to pregnant women? To answer this question, researchers from the Barcelona Institute for Global Health (ISGlobal), an institution supported by 'la Caixa,' conducted a systematic review and meta-analysis of studies that reported cases of accidental exposure to the drug among pregnant women.

Going to sleep on your back in late pregnancy
This study looked at whether going to sleep on your back in the third trimester of pregnancy was associated with average lower birth weights.

Read More: Pregnancy News and Pregnancy Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.