Nav: Home

Center for BrainHealth advances understanding of brain connectivity in cannabis users

July 02, 2020

DALLAS (July 2, 2020) - Researchers at Center for BrainHealth®, part of The University of Texas at Dallas, recently examined underlying brain networks in long-term cannabis users to identify patterns of brain connectivity when the users crave or have a desire to consume cannabis. While regional brain activation and static connectivity in response to cravings have been studied before, fluctuations in brain network connectivity had not yet been examined in cannabis users. The findings from this study will help support the development of better treatment strategies for cannabis dependence.

The study was published in the journal of Human Brain Mapping (May 2020) by researchers Francesca Filbey, PhD, professor and director of cognitive neuroscience research of addictive disorders at Center for BrainHealth, Hye Bin Yoo, PhD and Blake Edward Moya.

The findings add to the understanding that regions of the brain do not perform in isolation, but through connectivity of multiple brain networks that signal to each other depending on need and state. It further identifies that brain connectivity during craving is not static, but rather, has fluctuations in connection patterns between reward-related regions such as the central executive network and the nucleus accumbens, areas rich in dopamine. It also highlighted the need to better understand the impact of these dynamic patterns as it relates to cannabis use. Participants were examined with a functional magnetic resonance imaging (fMRI) scanner for these findings.

These findings further extend an earlier study published by Filbey et al in PNAS (August 2009), wherein the Filbey Lab described the first evidence of underlying neural mechanisms during cravings of cannabis users. The findings showed that chronic users not only have increased neural response in reward-related brain regions when there is a desire to consume cannabis, but that the magnitude of the response is associated with the severity of cannabis-related problems.

"Now that we have identified there are differences in large-scale brain network patterns in long-term cannabis users when there is craving, we can use these as biomarkers of cannabis use disorder to aid treatment strategies. Future studies are needed to determine how these brain network patterns might change over the course of treatment and recovery," said Dr. Filbey.

This study was helped funded by the National Institute of Drug Abuse, “Genetic and Environmental Modulators of the Brain's Response to Marijuana Cues" grant.

 

ABOUT THE CENTER FOR BRAINHEALTH®
The Center for BrainHealth, part of The University of Texas at Dallas, is a research institute committed to enhancing, preserving and restoring brain health across the lifespan. Scientific exploration at the Center for BrainHealth is leading edge, improving lives today and translating groundbreaking discoveries into practical clinical application. By delivering science-based innovations that enhance how people think, work and live, the Center and its Brain Performance Institute™ are empowering people of all ages to unlock their brain potential. Major research areas include the use of functional and structural neuroimaging techniques to better understand the neurobiology supporting cognition and emotion in health and disease.

Center for BrainHealth

Related Brain Articles:

Human brain size gene triggers bigger brain in monkeys
Dresden and Japanese researchers show that a human-specific gene causes a larger neocortex in the common marmoset, a non-human primate.
Unique insight into development of the human brain: Model of the early embryonic brain
Stem cell researchers from the University of Copenhagen have designed a model of an early embryonic brain.
An optical brain-to-brain interface supports information exchange for locomotion control
Chinese researchers established an optical BtBI that supports rapid information transmission for precise locomotion control, thus providing a proof-of-principle demonstration of fast BtBI for real-time behavioral control.
Transplanting human nerve cells into a mouse brain reveals how they wire into brain circuits
A team of researchers led by Pierre Vanderhaeghen and Vincent Bonin (VIB-KU Leuven, Université libre de Bruxelles and NERF) showed how human nerve cells can develop at their own pace, and form highly precise connections with the surrounding mouse brain cells.
Brain scans reveal how the human brain compensates when one hemisphere is removed
Researchers studying six adults who had one of their brain hemispheres removed during childhood to reduce epileptic seizures found that the remaining half of the brain formed unusually strong connections between different functional brain networks, which potentially help the body to function as if the brain were intact.
Alcohol byproduct contributes to brain chemistry changes in specific brain regions
Study of mouse models provides clear implications for new targets to treat alcohol use disorder and fetal alcohol syndrome.
Scientists predict the areas of the brain to stimulate transitions between different brain states
Using a computer model of the brain, Gustavo Deco, director of the Center for Brain and Cognition, and Josephine Cruzat, a member of his team, together with a group of international collaborators, have developed an innovative method published in Proceedings of the National Academy of Sciences on Sept.
BRAIN Initiative tool may transform how scientists study brain structure and function
Researchers have developed a high-tech support system that can keep a large mammalian brain from rapidly decomposing in the hours after death, enabling study of certain molecular and cellular functions.
Wiring diagram of the brain provides a clearer picture of brain scan data
In a study published today in the journal BRAIN, neuroscientists led by Michael D.
Blue Brain Project releases first-ever digital 3D brain cell atlas
The Blue Brain Cell Atlas is like ''going from hand-drawn maps to Google Earth'' -- providing previously unavailable information on major cell types, numbers and positions in all 737 brain regions.
More Brain News and Brain Current Events

Trending Science News

Current Coronavirus (COVID-19) News

Top Science Podcasts

We have hand picked the top science podcasts of 2020.
Now Playing: TED Radio Hour

Warped Reality
False information on the internet makes it harder and harder to know what's true, and the consequences have been devastating. This hour, TED speakers explore ideas around technology and deception. Guests include law professor Danielle Citron, journalist Andrew Marantz, and computer scientist Joy Buolamwini.
Now Playing: Science for the People

#576 Science Communication in Creative Places
When you think of science communication, you might think of TED talks or museum talks or video talks, or... people giving lectures. It's a lot of people talking. But there's more to sci comm than that. This week host Bethany Brookshire talks to three people who have looked at science communication in places you might not expect it. We'll speak with Mauna Dasari, a graduate student at Notre Dame, about making mammals into a March Madness match. We'll talk with Sarah Garner, director of the Pathologists Assistant Program at Tulane University School of Medicine, who takes pathology instruction out of...
Now Playing: Radiolab

What If?
There's plenty of speculation about what Donald Trump might do in the wake of the election. Would he dispute the results if he loses? Would he simply refuse to leave office, or even try to use the military to maintain control? Last summer, Rosa Brooks got together a team of experts and political operatives from both sides of the aisle to ask a slightly different question. Rather than arguing about whether he'd do those things, they dug into what exactly would happen if he did. Part war game part choose your own adventure, Rosa's Transition Integrity Project doesn't give us any predictions, and it isn't a referendum on Trump. Instead, it's a deeply illuminating stress test on our laws, our institutions, and on the commitment to democracy written into the constitution. This episode was reported by Bethel Habte, with help from Tracie Hunte, and produced by Bethel Habte. Jeremy Bloom provided original music. Support Radiolab by becoming a member today at Radiolab.org/donate.     You can read The Transition Integrity Project's report here.