Gene expression in lung tumors

July 03, 2006

In an attempt to develop a classification of human lung tumors that might help to predict outcome, Hongye Liu and colleagues from the Children's Hospital Boston compared gene expression patterns in patients with lung cancer with those seen during mouse lungs during development. They show that the human tumors that had a gene expression pattern most similar to that seen in early mouse lung development had a poorer outcome.
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Citation: Liu H, Kho AT, Kohane IS, Sun Y (2006) Predicting survival within the lung cancer histopathological hierarchy using a multi-scale genomic model of development. PLoS Med 3(7): e232.

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VERSIONS OF YOUR REPORT: http://dx.doi.org/10.1371/journal.pmed.0030232

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CONTACT:
Hongye Liu
Children's Hospital Boston
Informatics
320 Longwood Ave.
Boston, MA 02115 United States of America
+1-617-355-5188
+1-617-730-0921 (fax)
hongye.liu@childrens.harvard.edu

About PLoS Medicine
PLoS Medicine is an open access, freely available international medical journal. It publishes original research that enhances our understanding of human health and disease, together with commentary and analysis of important global health issues. For more information, visit http://www.plosmedicine.org

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