Nav: Home

Blood of SIDS infants contains high levels of serotonin

July 03, 2017

WHAT:

Blood samples from infants who died of Sudden Infant Death Syndrome (SIDS) had high levels of serotonin, a chemical that carries signals along and between nerves, according to a study funded in part by the National Institutes of Health. The finding raises the possibility that a test could be developed to distinguish SIDS cases from other causes of sleep-related, unexpected infant death. The study, led by Robin L. Haynes, Ph.D., of Boston Children's Hospital and Harvard Medical School, appears in the Proceedings of the National Academy of Sciences. NIH's Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) provided funding for the work.

SIDS is the sudden death of an infant under one year of age that remains unexplained after a complete autopsy and death scene investigation. In the current study, researchers reported that 31 percent of SIDS infants (19 of 61) had elevated blood levels of serotonin. In previous studies, the researchers reported multiple serotonin-related brain abnormalities in SIDS cases, including a decrease in serotonin in regions involved in breathing, heart rate patterns, blood pressure, temperature regulation, and arousal during sleep.

Taken together, the researchers wrote, the findings suggest that an abnormality in serotonin metabolism could indicate an underlying vulnerability that increases SIDS risk and that testing blood samples for serotonin could distinguish certain SIDS cases from other infant deaths. However, they caution that more research is needed.

NICHD's Safe to Sleep campaign provides information on ways to reduce the risk of SIDS and other sleep-related causes of infant death.

WHAT:

Rosemary Higgins, M.D., of the NICHD Pregnancy and Perinatology Branch, which oversaw the study, is available for comment.
-end-
ARTICLE:

Haynes, RL, et al. High Serum Serotonin in Sudden Infant Death Syndrome. Proceedings of the National Academy of Sciences.

About the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD): NICHD conducts and supports research in the United States and throughout the world on fetal, infant and child development; maternal, child and family health; reproductive biology and population issues; and medical rehabilitation. For more information, visit NICHD's website.

About the National Institutes of Health (NIH): NIH, the nation's medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit http://www.nih.gov.

NIH/Eunice Kennedy Shriver National Institute of Child Health and Human Development

Related Serotonin Articles:

First look at how hallucinogens bind structurally to serotonin receptors
Although hallucinogenic drugs have been studied for decades, little is known about the underlying mechanisms in the brain by which they induce their effects.
Guilt by dissociation: Study sheds light on serotonin in autism
A study on serotonin, a mood-regulating molecule in the brain that regulates many brain synapses, is helping to unravel the puzzle surrounding its role in autism.
How serotonin balances communication within the brain
Our brain is steadily engaged in soliloquies. These internal communications are usually also bombarded with external sensory events.
Why do we freeze when startled? New study in flies points to serotonin
A Columbia University study in fruit flies has identified serotonin as a chemical that triggers the body's startle response, the automatic deer-in-the-headlights reflex that freezes the body momentarily in response to a potential threat.
Settling the debate on serotonin's role in sleep
New research finds that serotonin is necessary for sleep, settling a long-standing controversy.
Whole grain can contribute to health by changing intestinal serotonin production
Adults consuming whole grain rye have lower plasma serotonin levels than people eating low-fibre wheat bread, according to a recent study by the University of Eastern Finland and the International Agency for Research on Cancer (IARC).
Serotonin boosts neuronal powerplants protecting against stress
Research from the Vaidya and Kolthur-Seetharam groups (TIFR) shows that the neurotransmitter serotonin enhances the production and functions of neuronal mitochondria, the powerhouse of the cell, and protect against stress.
Fight or flight: Serotonin neurons prompt brain to make the right call
Known for its role in relieving depression, the neurochemical serotonin may also help the brain execute instantaneous, appropriate behaviors in emergency situations, according to a new Cornell study published Feb.
New images show serotonin activating its receptor for first time
A team of researchers from Case Western Reserve University School of Medicine have used high-powered microscopes to view serotonin activating its receptor for the first time.
Serotonin-Noradrenalin reuptake inhibitors may cause dependence and withdrawal when stopped
The difficulties that people have in discontinuing antidepressant medications has been in the news recently.
More Serotonin News and Serotonin Current Events

Trending Science News

Current Coronavirus (COVID-19) News

Top Science Podcasts

We have hand picked the top science podcasts of 2020.
Now Playing: TED Radio Hour

Listen Again: The Power Of Spaces
How do spaces shape the human experience? In what ways do our rooms, homes, and buildings give us meaning and purpose? This hour, TED speakers explore the power of the spaces we make and inhabit. Guests include architect Michael Murphy, musician David Byrne, artist Es Devlin, and architect Siamak Hariri.
Now Playing: Science for the People

#576 Science Communication in Creative Places
When you think of science communication, you might think of TED talks or museum talks or video talks, or... people giving lectures. It's a lot of people talking. But there's more to sci comm than that. This week host Bethany Brookshire talks to three people who have looked at science communication in places you might not expect it. We'll speak with Mauna Dasari, a graduate student at Notre Dame, about making mammals into a March Madness match. We'll talk with Sarah Garner, director of the Pathologists Assistant Program at Tulane University School of Medicine, who takes pathology instruction out of...
Now Playing: Radiolab

What If?
There's plenty of speculation about what Donald Trump might do in the wake of the election. Would he dispute the results if he loses? Would he simply refuse to leave office, or even try to use the military to maintain control? Last summer, Rosa Brooks got together a team of experts and political operatives from both sides of the aisle to ask a slightly different question. Rather than arguing about whether he'd do those things, they dug into what exactly would happen if he did. Part war game part choose your own adventure, Rosa's Transition Integrity Project doesn't give us any predictions, and it isn't a referendum on Trump. Instead, it's a deeply illuminating stress test on our laws, our institutions, and on the commitment to democracy written into the constitution. This episode was reported by Bethel Habte, with help from Tracie Hunte, and produced by Bethel Habte. Jeremy Bloom provided original music. Support Radiolab by becoming a member today at Radiolab.org/donate.     You can read The Transition Integrity Project's report here.