Nav: Home

Staph risk runs in families, especially among siblings

July 04, 2016

1. Staph risk runs in families, especially among siblings
Abstract: http://www.annals.org/article.aspx?doi=10.7326/M15-2762
URL goes live when the embargo lifts

Having a first-degree relative, especially a sibling, with a history of staph infection significantly increases a person's risk for the disease, regardless of sex of the family member, comorbid conditions, or direct contamination. The results of a large national study are published in Annals of Internal Medicine.

The incidence of Staphylococcus aureus bacteremia, or staph infection, has increased over the past few decades, with antibiotic resistance adding to the problem. Animal studies have shown a link between host genetics and staph infection, but whether human host genetics in general are associated with the risk for acquiring staph infection is unclear. This knowledge could have important implications for influencing future therapeutic interventions and strategies.

Researchers reviewed a national registry in Denmark to determine whether a history of S. aureus bacteremia in first-degree relatives is associated with an increased risk for microbiologically confirmed S. aureus bacteremia. They found that having a first-degree relative hospitalized with confirmed staph infection significantly increased a person's risk for the disease. The risk was significantly higher if the infected patient was a sibling than a parent. According to the researchers, the results are unlikely to be explained by direct transmission of the pathogen because more than 80 percent of exposed individuals acquiring staph were infected with a strain genetically different from the infected relative.

Note: For an embargoed PDF, please contact Cara Graeff. The lead author, Dr. Louise Bruun Østergaard, can be contacted directly at l_bruun@hotmail.com or (+45)28726461.




2. Rare condition mimics deep venous thrombosis
Abstract: http://www.annals.org/article.aspx?doi=10.7326/L15-0532
URL goes live when the embargo lifts

A rare condition characterized by unilateral lower extremity swelling can be mistaken for deep venous thrombosis (DVT), even by experienced clinicians. A case report is published in Annals of Internal Medicine.

DVT is usually easy for clinicians to identify due to its distinctive presentation, but a rare condition called adventitial cystic disease may mimic DVT symptoms. Authors describe the case of a 31-year-old woman who presented to the ER with painless, progressive right lower extremity swelling and tingling. Suspecting DVT, clinicians administered low-molecular-weight heparin therapy and discharged the patient home with arrangements for urgent Doppler ultrasonography as an outpatient. Further examination revealed that the patient did not have DVT, but adventitial cystic disease. Simple drainage of the cyst can be an effective treatment, but surgical resection is preferred given the risk for recurrence after aspiration. The patient tolerated surgery well and her symptoms resolved.

Note: For an embargoed PDF or contact information for one of the authors, please contact Cara Graeff.




3. Annals Graphic Medicine tackles the issue of high drug costs
Free content: http://www.annals.org/article.aspx?doi=10.7326/G16-0003
URL goes live when the embargo lifts

A new Annals Graphic Medicine feature entitled The Price of Progress highlights the issue of rising prescription drug costs. Annals Graphic Medicine uses the creativity of the graphic novel format to address medically relevant topics. These free features are often poignant and thought-provoking. A complete list of topics is available at http://www.annals.org/graphicmedicine.

Note: For an embargoed PDF, please contact Cara Graeff. For an interview with the author, Dr. Grace Farris, please contact Jennifer Kritz at jkritz@bidmc.harvard.edu.




Also new in this issue:

Use of Decision Models in the Development of Evidence-Based Clinical Preventive Services Recommendations: Methods of the U.S. Preventive Services Task Force
Douglas K. Owens, MD, MS; Evelyn P. Whitlock, MD, MPH; Jillian Henderson, PhD, MPH; Michael P. Pignone, MD, MPH; Alex H. Krist, MD, MPH; Kirsten Bibbins-Domingo, PhD, MD, MAS; Susan J. Curry, PhD; Karina W. Davidson, PhD, MASc; Mark Ebell, MD, MS; Matthew W. Gillman, MD, SM; David C. Grossman, MD, MPH; Alex R. Kemper, MD, MPH, MS; Ann E. Kurth, PhD, RN, MSN, MPH; Michael Maciosek, PhD; Albert L. Siu, MD, MSPH; and Michael L. LeFevre, MD, MPH; on behalf of the U.S. Preventive Services Task Force
Research and Reporting Methods

A Windbreaker's Warmth
Jamie K. Lim, BSc, Boston University School of Medicine, Boston, Massachusetts
On Being a Doctor

Brain Anatomy: Thoughts From the Inside
William T. Pordy, MD, New York, New York
On Being a Patient
-end-


American College of Physicians

Related Internal Medicine Articles:

COVID-19 news from Annals of Internal Medicine
In this Ideas and Opinions piece from the University of California, San Francisco and San Francisco Veterans Affairs Medical Center, the authors discuss the findings of early studies that addressed the use of chest computed tomography for the detection of COVID-19.
New COVID-19 content from Annals of Internal Medicine
Below please find links to new coronavirus-related content published today in Annals of Internal Medicine.
Changes in internal medicine subspecialty choices of women, men
This study used enrollment data to examine changes in the internal medicine subspecialty choices of women and men from 1991 to 2016.
Do internal medicine residents feel bullied during training?
This research letter uses survey data to report on perceived bullying by internal medicine residents during training.
Annals publishes annual updates in internal medicine
Annals of Internal Medicine, the flagship journal of the American College of Physicians (ACP), has published summaries of the most important medical studies published in 2016 in the fields of general internal medicine, cardiology, hematology, endocrinology, gastroenterology and hepatology, rheumatology, and perioperative, pulmonary, and geriatric medicine.
News from Annals of Internal Medicine April 7, 2015
In the next issue of Annals of Internal Medicine are: Weight Watchers and Jenny Craig come out on top among commercial weight loss programs; Physical therapy as effective as surgery for lumber spinal stenosis; and Leading internists call for more thoughtful use of CPR.
News from Annals of Internal Medicine March 31, 2015
Articles include: USPSTF reviews evidence to update recommendations on iron supplementation and deficiency screening in pregnant women; New hep C treatments are cost-effective for some patients, yet may exceed insurers' willingness to pay.
News from Annals of Internal Medicine March 24, 2015
The US Preventive Services Task Force concludes that the current evidence is insufficient to recommend for or against screening for thyroid dysfunction in nonpregnant, asymptomatic adults.
News from Annals of Internal Medicine Feb. 10, 2015
Using Lung Imaging Reporting and Data System (Lung-RADS) criteria developed by the American College of Radiology to interpret low-dose CT lung screening results may reduce false positives compared to the National Lung Screening Trial, but the trade-off is reduced sensitivity, according to an article published in Annals of Internal Medicine.
News from Dec. 23, 2014, Annals of Internal Medicine
The Dec. 23, 2014, issue of Annals of Internal Medicine includes 'Blood pressure drugs likely to prevent stroke and death in patients with mild hypertension' and 'Task force reviews evidence to update blood pressure screening recommendations.'
More Internal Medicine News and Internal Medicine Current Events

Trending Science News

Current Coronavirus (COVID-19) News

Top Science Podcasts

We have hand picked the top science podcasts of 2020.
Now Playing: TED Radio Hour

Clint Smith
The killing of George Floyd by a police officer has sparked massive protests nationwide. This hour, writer and scholar Clint Smith reflects on this moment, through conversation, letters, and poetry.
Now Playing: Science for the People

#562 Superbug to Bedside
By now we're all good and scared about antibiotic resistance, one of the many things coming to get us all. But there's good news, sort of. News antibiotics are coming out! How do they get tested? What does that kind of a trial look like and how does it happen? Host Bethany Brookeshire talks with Matt McCarthy, author of "Superbugs: The Race to Stop an Epidemic", about the ins and outs of testing a new antibiotic in the hospital.
Now Playing: Radiolab

Dispatch 6: Strange Times
Covid has disrupted the most basic routines of our days and nights. But in the middle of a conversation about how to fight the virus, we find a place impervious to the stalled plans and frenetic demands of the outside world. It's a very different kind of front line, where urgent work means moving slow, and time is marked out in tiny pre-planned steps. Then, on a walk through the woods, we consider how the tempo of our lives affects our minds and discover how the beats of biology shape our bodies. This episode was produced with help from Molly Webster and Tracie Hunte. Support Radiolab today at Radiolab.org/donate.