The role of electrochemotherapy in radiosensitization of tumor cells

July 04, 2017

Radiotherapy is an important method in treatment of tumors, but it can be held responsible for biological damages. Improvements in this therapeutic method have begun by developing targeted drug delivery system along with developing efficient radiosensitizing agents through which targeted uptake of the chemotherapeutic drugs into the tumor cells and tumor specific sensitization are increased. Electroporation (EP) has shown promising potentials as a targeted drug delivery system and radiosensitizing technique. EP increases chemotherapy drug uptake in the tumor cells which in turn increases its intracellular accumulation and thus the radiosensitizing effect. When EP is combined by chemotherapeutic drugs, this treatment is named ECT.

There are two basic requirements for an effective ECT: (1) appropriate electrical parameters and (2) type, administration route, and concentration of chemotherapeutic agent. In all studies (preclinical & clinical), the best treatment response was obtained in the group that treated with ECT before irradiation. In addition, previous studies showed that the skin tumors of the head and neck can be successfully treated with a combination of ECT and electron beam in clinics. We can conclude that combination of ECT and radiotherapy can be considered for patients with progressive skin tumors in the head and neck area to increase the likelihood of a favorable therapeutic outcome and to preserve cosmetic appearance and function of the normal surrounding tissues.

In summary, three main mechanisms have been reportedly responsible for radiosensitizing effect of ECT: (1) increased drug uptake in the cells due to EP phenomenon, (2) generation of reactive oxygen species by electric pulses, and (3) vascular alteration particularly antivascular effects.
-end-
For further information about this research, please visit: http://www.eurekaselect.com/153527

Reference: Rezaee Z et al(2017). Radiosensitizing effect of electrochemotherapy: A systematic review of protocols and efficiency, Current Drug Targets, DOI: 10.2174/1389450118666170622091014

Bentham Science Publishers

Related Tumor Cells Articles from Brightsurf:

Cancer researchers train white blood cells to attacks tumor cells
Scientists at the National Center for Tumor Diseases Dresden (NCT/UCC) and Dresden University Medicine, together with an international team of researchers, were able to demonstrate that certain white blood cells, so-called neutrophil granulocytes, can potentially - after completing a special training program -- be utilized for the treatment of tumors.

How to prevent the spread of tumor cells via the lymph vessels
Scientists from the German Cancer Research Center and the Mannheim Medical Faculty of the University of Heidelberg identified a new way to block the dangerous spread of tumor cells via lymphatic vessels.

The CNIO reprograms CRISPR system in mice to eliminate tumor cells without affecting healthy cells
CNIO researchers destroyed Ewing's sarcoma and chronic myeloid leukaemia tumor cells by using CRISPR to cut out the fusion genes that cause them.

Feeding off fusion or the immortalization of tumor cells
Despite all recent progress, cancer remains one of the deadliest human diseases.

How do tumor cells divide in the crowd?
Scientists led by Dr. Elisabeth Fischer-Friedrich, group leader at the Excellence Cluster Physics of Life (PoL) and the Biotechnology Center TU Dresden (BIOTEC) studied how cancer cells are able to divide in a crowded tumor tissue and connected it to the hallmark of cancer progression and metastasis, the epithelial-mesenchymal transition (EMT).

How tumor cells evade the immune defense
Scientists are increasingly trying to use the body's own immune system to fight cancer.

Engineered immune cells recognize, attack human and mouse solid-tumor cancer cells
CAR-T therapy has been used successfully in patients with blood cancers such as lymphoma and leukemia.

New pathway to attack tumor cells identified
A study led by the Institut de Neurociències (INc-UAB) describes a new strategy to tackle cancer, based on inducing a potent stress in tumor causing cell destruction by autophagy.

Nutrient deficiency in tumor cells attracts cells that suppress the immune system
A study led by IDIBELL researchers and published this week in the American journal PNAS shows that, by depriving tumor cells of glucose, they release a large number of signaling molecules.

Blocking sugar structures on viruses and tumor cells
During a viral infection, viruses enter the body and multiply in its cells.

Read More: Tumor Cells News and Tumor Cells Current Events
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.