Pre-exposure prophylaxis for HIV infection

July 05, 2007

Clinical trials of pre-exposure prophylaxis -- that is giving anti-retroviral drugs to non-HIV-infected individuals to prevent them becoming infected -- are exploring whether the approach could lead to a large decrease in transmission of the virus with few or no side effects. However implementation of a pre-exposure prophylaxis programme, if the intervention is proven effective, will require careful planning and substantial resources. These issues are discussed in a Viewpoint in this week's edition of The Lancet.

Several phase II and III trials of anti-retroviral drug combinations such as tenofovir and emtricitabine are being studied among various at-risk populations, including men who have sex with men, injecting-drug users, and heterosexual men and women.

Dr Lynn Paxton, Centers for Disease Control and Prevention, Atlanta, Georgia, USA and colleagues discuss the implementation issues that will need to be addressed including: ensuring access to those at risk; minimizing potential increases in risk behaviour; and minimizing the possibility of development of drug resistant forms of the virus. The authors argue that because efficacy results from the ongoing studies may be available as early as 2008, preliminary planning for implementation should start now.


Related Virus Articles from Brightsurf:

Researchers develop virus live stream to study virus infection
Researchers from the Hubrecht Institute and Utrecht University developed an advanced technique that makes it possible to monitor a virus infection live.

Will the COVID-19 virus become endemic?
A new article in the journal Science by Columbia Mailman School researchers Jeffrey Shaman and Marta Galanti explores the potential for the COVID-19 virus to become endemic, a regular feature producing recurring outbreaks in humans.

Smart virus
HSE University researchers have found microRNA molecules that are potentially capable of repressing the replication of human coronaviruses, including SARS-CoV-2.

COVID-19 - The virus and the vasculature
In severe cases of COVID-19, the infection can lead to obstruction of the blood vessels in the lung, heart and kidneys.

Lab-made virus mimics COVID-19 virus
Researchers at Washington University School of Medicine in St. Louis have created a virus in the lab that infects cells and interacts with antibodies just like the COVID-19 virus, but lacks the ability to cause severe disease.

Virus prevalence associated with habitat
Levels of virus infection in lobsters seem to be related to habitat and other species, new studies of Caribbean marine protected areas have shown.

Herpes virus decoded
The genome of the herpes simplex virus 1 was decoded using new methods.

A new biosensor for the COVID-19 virus
A team of researchers from Empa, ETH Zurich and Zurich University Hospital has succeeded in developing a novel sensor for detecting the new coronavirus.

How at risk are you of getting a virus on an airplane?
New 'CALM' model on passenger movement developed using Frontera supercomputer.

Virus multiplication in 3D
Vaccinia viruses serve as a vaccine against human smallpox and as the basis of new cancer therapies.

Read More: Virus News and Virus Current Events is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to